PMID- 35729517
OWN - NLM
STAT- MEDLINE
DCOM- 20220623
LR  - 20220726
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jun 21
TI  - Catechol-O-methyltransferase activity in individuals with substance use 
      disorders: a case control study.
PG  - 412
LID - 10.1186/s12888-022-04068-x [doi]
LID - 412
AB  - BACKGROUND: Impulsivity and substance use disorders (SUD) have been both 
      associated with changes in dopaminergic processes. In this study, we intended to 
      evaluate the dopaminergic function in imprisoned SUD offenders through the 
      determination of s-COMT activity. METHODS: The study included 46 male individuals 
      from a Portuguese penal institution. The participants were assessed through a 
      battery of standardised instruments: Psychopathy Checklist-Revised (PCL-R), 
      Barratt Impulsivity Scale Version 11 (BIS-11), and the European version of the 
      Addiction Severity Index (EuropASI). In addition, s-COMT erythrocyte activity was 
      evaluated. RESULTS: Overall, 73.9% (n = 34) of the individuals had Antisocial 
      personality disorder (ASPD) and 58.7% (n = 27) presented SUD. We evidenced, for 
      the first time, that, in individuals with SUD, s-COMT activity was correlated 
      with the severity of drug dependence (EuropASI) (p = 0.009), and with BIS-11 
      factors self-control (p < 0.0001) and non-planning (p = 0.002). CONCLUSIONS: This 
      study opens new perspectives regarding the pharmacological intervention on 
      substance dependence through the interference on dopamine pathways.
CI  - (c) 2022. The Author(s).
FAU - da Costa Azevedo, Jacinto Nuno
AU  - da Costa Azevedo JN
AD  - Department of Neuroscience and Mental Health, Faculty of Medicine, University of 
      Porto, Rua da Alegria 2083, 4200-027, Porto, Portugal. jacintoazevedo@gmail.com.
AD  - i3S - Institute for Research and Innovation in Health, University of Porto, Rua 
      da Alegria 2083, 4200-027, Porto, Portugal. jacintoazevedo@gmail.com.
FAU - Carvalho, Claudia
AU  - Carvalho C
AD  - Department of Biomedicine-Therapeutics and Pharmacology Unit, Faculty of 
      Medicine, University of Porto, Porto, Portugal.
FAU - Serrao, Maria Paula
AU  - Serrao MP
AD  - Department of Biomedicine-Therapeutics and Pharmacology Unit, Faculty of 
      Medicine, University of Porto, Porto, Portugal.
FAU - Coelho, Rui
AU  - Coelho R
AD  - Department of Neuroscience and Mental Health, Faculty of Medicine, University of 
      Porto, Rua da Alegria 2083, 4200-027, Porto, Portugal.
AD  - Centro Hospitalar Universitario Sao Joao, Porto, Portugal.
FAU - Figueiredo-Braga, Margarida
AU  - Figueiredo-Braga M
AD  - Department of Neuroscience and Mental Health, Faculty of Medicine, University of 
      Porto, Rua da Alegria 2083, 4200-027, Porto, Portugal.
AD  - i3S - Institute for Research and Innovation in Health, University of Porto, Rua 
      da Alegria 2083, 4200-027, Porto, Portugal.
FAU - Vieira-Coelho, Maria Augusta
AU  - Vieira-Coelho MA
AD  - Department of Biomedicine-Therapeutics and Pharmacology Unit, Faculty of 
      Medicine, University of Porto, Porto, Portugal.
AD  - Centro Hospitalar Universitario Sao Joao, Porto, Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220621
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - EC 2.1.1.6 (COMT protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Antisocial Personality Disorder/enzymology
MH  - Case-Control Studies
MH  - *Catechol O-Methyltransferase/metabolism
MH  - Humans
MH  - Male
MH  - Prisoners
MH  - *Substance-Related Disorders/enzymology
PMC - PMC9210590
OTO - NOTNLM
OT  - Case-control study
OT  - Impulsivity
OT  - S-COMT activity
OT  - Substance use disorders (SUD)
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/06/22 06:00
MHDA- 2022/06/24 06:00
PMCR- 2022/06/21
CRDT- 2022/06/21 23:37
PHST- 2021/10/18 00:00 [received]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/06/21 23:37 [entrez]
PHST- 2022/06/22 06:00 [pubmed]
PHST- 2022/06/24 06:00 [medline]
PHST- 2022/06/21 00:00 [pmc-release]
AID - 10.1186/s12888-022-04068-x [pii]
AID - 4068 [pii]
AID - 10.1186/s12888-022-04068-x [doi]
PST - epublish
SO  - BMC Psychiatry. 2022 Jun 21;22(1):412. doi: 10.1186/s12888-022-04068-x.