PMID- 35729758
OWN - NLM
STAT- MEDLINE
DCOM- 20220623
LR  - 20220623
IS  - 2375-6322 (Electronic)
IS  - 2375-6314 (Linking)
VI  - 93
IP  - 6
DP  - 2022 Jun 1
TI  - Cognitive, Sleep, and Autonomic Responses to Induction of a Ketogenic Diet in 
      Military Personnel: A Pilot Study.
PG  - 507-516
LID - 10.3357/AMHP.6015.2022 [doi]
AB  - BACKGROUND: This pilot study examined the effect of a 2-wk ketogenic diet (KD) 
      compared with a carbohydrate (CHO) diet in military personnel on cognitive 
      performance, mood, sleep, and heart rate variability (HRV).METHODS: A 
      randomized-controlled, cross-over trial was conducted with eight male military 
      personnel (age, 36 +/- 7 yr; body mass, 83.7 +/- 9.2 kg; BMI, 26.0 +/- 2.3 kg . m(-2)). 
      Subjects ingested their habitual diet for 7 d (baseline), then an iso-energetic 
      KD ( approximately 25 g CHO/d) or CHO diet ( approximately 285 g CHO/d) for 14 d (adaptation), separated by a 
      12-d washout. HRV, fasting capillary blood D-betaHB, and glucose concentration, 
      mood, and sleep were measured daily. Cognitive performance was measured on the 
      7(th) day of baseline and the 7(th) and 14(th) days of adaptation. Data were 
      analyzed using a series of linear mixed models.RESULTS: Mean weekly D-betaHB was 
      higher (95% CI, +0.34 to +2.38 mmol . L(-1)) and glucose was lower (-0.45 to 
      -0.21 mmol . L(-1)) in the KD compared with the CHO diet. Cognitive performance 
      (Psychomotor Vigilance Task, 2-choice reaction time, and running memory 
      continuous performance test) and mean weekly fatigue, vigor, and sleep (sleep 
      duration, sleep efficiency, and sleep onset latency) were similar between diets. 
      A diet x week interaction for HRV approached significance, with exploratory 
      analyses suggesting HRV was lower compared with baseline during week-2 adapt (-27 
      to +4 ms) in the KD.DISCUSSION: A 2-wk KD induction in military personnel does 
      not appear to affect cognitive performance, mood, or sleep, but may lower HRV, 
      indicating increased physiological stress.Shaw DM, Henderson L, van den Berg M. 
      Cognitive, sleep, and autonomic responses to induction of a ketogenic diet in 
      military personnel: a pilot study. Aerosp Med Hum Perform. 2022; 93(6):507-516.
FAU - Shaw, David M
AU  - Shaw DM
FAU - Henderson, Lydia
AU  - Henderson L
FAU - van den Berg, Margo
AU  - van den Berg M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Aerosp Med Hum Perform
JT  - Aerospace medicine and human performance
JID - 101654770
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Cognition/physiology
MH  - *Diet, Ketogenic
MH  - Glucose
MH  - Humans
MH  - Male
MH  - *Military Personnel
MH  - Pilot Projects
MH  - Sleep
EDAT- 2022/06/23 06:00
MHDA- 2022/06/24 06:00
CRDT- 2022/06/22 00:33
PHST- 2022/06/22 00:33 [entrez]
PHST- 2022/06/23 06:00 [pubmed]
PHST- 2022/06/24 06:00 [medline]
AID - 10.3357/AMHP.6015.2022 [doi]
PST - ppublish
SO  - Aerosp Med Hum Perform. 2022 Jun 1;93(6):507-516. doi: 10.3357/AMHP.6015.2022.