PMID- 35730792
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20220706
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 13
IP  - 13
DP  - 2022 Jul 4
TI  - Black bean husk and black rice anthocyanin extracts modulated gut microbiota and 
      serum metabolites for improvement in type 2 diabetic rats.
PG  - 7377-7391
LID - 10.1039/d2fo01165d [doi]
AB  - Black rice and black bean have not yet been fully investigated as healthy foods 
      for their therapeutic effects on type 2 diabetes mellitus (T2DM). In this study, 
      we aimed to evaluate the antidiabetic effects of black rice, black bean husk 
      anthocyanin extracts, and their combination on glycolipid metabolism, gut 
      microbiota, and serum metabolites in T2DM rats. Black bean husk and black rice 
      anthocyanin extracts were administered to T2DM rats by gavage for 4 weeks. The 
      results showed that black rice and black bean husk anthocyanin extracts 
      significantly improved blood glucose, insulin resistance, serum oxidative stress 
      state, lipid metabolism and inflammatory cytokines levels in rats, and alleviated 
      liver damage. Black rice and black bean husk anthocyanin extracts increased the 
      abundance of short-chain fatty acid (SCFA) producing bacteria Akkermansia spp., 
      Phascolarctobacterium spp., Bacteroides spp., and Coprococcus spp., changed the 
      gut microbiota structure; activated AMPK, PI3K, and AKT; inhibited HMGCR, G6pase 
      and PEPCK expression; and inhibited hepatic gluconeogenesis. Moreover, by 
      adjusting the levels of urea, deoxycytidine, L-citrulline, pseudouridine, and 
      other serum metabolites in T2DM rats, the arginine biosynthesis and pyrimidine 
      metabolism pathways were downregulated. The above results indicated that black 
      rice and black bean husk anthocyanin extracts had a significant impact on the 
      development of T2DM.
FAU - Sun, Mubai
AU  - Sun M
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
FAU - Li, Da
AU  - Li D
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
FAU - Hua, Mei
AU  - Hua M
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
FAU - Miao, Xinyu
AU  - Miao X
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
FAU - Su, Ying
AU  - Su Y
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
FAU - Chi, Yanping
AU  - Chi Y
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
FAU - Li, Yueqiao
AU  - Li Y
AD  - Department of International Cooperation, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China.
FAU - Sun, Ruiyue
AU  - Sun R
AD  - Department of Food Science and Engineering, College of Agriculture, Yanbian 
      University, Yanji, 133000, Jilin, China.
FAU - Niu, Honghong
AU  - Niu H
AUID- ORCID: 0000-0002-6006-7843
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
FAU - Wang, Jinghui
AU  - Wang J
AD  - Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, 
      130033, Changchun, Jilin, China. nhh29852@cjaas.com.
LA  - eng
PT  - Journal Article
DEP - 20220704
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Anthocyanins)
SB  - IM
MH  - Animals
MH  - Anthocyanins/pharmacology
MH  - *Diabetes Mellitus, Experimental/drug therapy
MH  - *Diabetes Mellitus, Type 2/drug therapy/metabolism
MH  - *Gastrointestinal Microbiome
MH  - *Oryza
MH  - Rats
EDAT- 2022/06/23 06:00
MHDA- 2022/07/07 06:00
CRDT- 2022/06/22 08:13
PHST- 2022/06/23 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/06/22 08:13 [entrez]
AID - 10.1039/d2fo01165d [doi]
PST - epublish
SO  - Food Funct. 2022 Jul 4;13(13):7377-7391. doi: 10.1039/d2fo01165d.