PMID- 35731329
OWN - NLM
STAT- MEDLINE
DCOM- 20230303
LR  - 20230328
IS  - 1572-8595 (Electronic)
IS  - 1383-875X (Linking)
VI  - 66
IP  - 2
DP  - 2023 Mar
TI  - Successful radiofrequency catheter ablation of idiopathic premature ventricular 
      complexes originating from the outflow tract improves heart failure-related 
      quality of life.
PG  - 363-372
LID - 10.1007/s10840-022-01264-3 [doi]
AB  - BACKGROUND: To investigate the effect of successful RFCA in patients with 
      idiopathic outflow tract PVCs (OT-PVC) on left heart functions, neurohormonal 
      activation, functional status, and heart failure-related quality of life (HFQoL), 
      with an integrated approach. METHODS: Patients with frequent OT-PVCs, determined 
      by 12-lead surface ECG who underwent radiofrequency catheter ablation (RFCA) with 
      an acute success, were prospectivelly enrolled. Left heart functions were 
      evaluated with the use of transthoracic echocardiography, neurohormonal 
      activation with N-terminal Pro-brain natriuretic peptide (BNP), functional class 
      with New York Heart Association (NYHA) and 6-min walking distance (6MWD), and 
      HFQoL with Minnesota Living with Heart Failure Questionnaire (MLHFQ), at baseline 
      and at 6 months. RESULTS: A total of 108 patients were included in this study 
      (43 +/- 12 years old, 56% male). Majority of the OT-PVCs originated from aortic 
      valve and right ventricle outflow tract (44% and 37%, respectively). Total RF 
      time was 216 +/- 87 s. Major complication rate was 0.9%. Left ventricle (LV) 
      ejection fraction increased from 47 +/- 8 to 53 +/- 6% at 6 months (p < 0.001). 
      Neurohormonal activation was suppressed significantly (104 +/- 69 to 83 +/- 42, 
      p < 0.001). Functional class improved with %NYHA-I patients increasing from 54 to 
      89% (p < 0.001) and 6MWD from 293 +/- 73 to 335 +/- 59 m (p < 0.001). MLHFQ score 
      improved from 32 +/- 9 to 23 +/- 5 p < 0.001. In multivariable analysis, LV 
      end-systolic diameter (LVESD) and 6MWD were independent predictors of improvement 
      in MLHFQ (for LVESD Ubeta: - 0.26, 95%CI [0.44-0.09], p < 0.004 and for 6MWD: 0.04, 
      95%CI [0.03-0.06], p < 0.001). CONCLUSIONS: RFCA of OT-PVCs is associated with 
      improved well-being of patients, determined by left heart functions, 
      neurohormonal activation, functional class, and HFQoL.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Ozveren, Olcay
AU  - Ozveren O
AD  - Department of Cardiology, Yeditepe University Hospital, Hastahane Sok. No: 4, 
      34752, Istanbul, Turkey.
FAU - Mutluer, Ferit Onur
AU  - Mutluer FO
AD  - Department of Cardiology, Yeditepe University Hospital, Hastahane Sok. No: 4, 
      34752, Istanbul, Turkey.
AD  - Department of Cardiology, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
FAU - Tutuncu, Ahmet
AU  - Tutuncu A
AD  - Department of Cardiology, Bursa Postgraduate Hospital, Bursa, Turkey.
FAU - Tenekecioglu, Erhan
AU  - Tenekecioglu E
AD  - Department of Cardiology, Bursa Postgraduate Hospital, Bursa, Turkey.
FAU - Kanat, Selcuk
AU  - Kanat S
AD  - Department of Cardiology, Bursa Postgraduate Hospital, Bursa, Turkey.
FAU - Aksu, Tolga
AU  - Aksu T
AUID- ORCID: 0000-0001-8061-9660
AD  - Department of Cardiology, Yeditepe University Hospital, Hastahane Sok. No: 4, 
      34752, Istanbul, Turkey. aksutolga@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220622
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - Humans
MH  - Male
MH  - Adult
MH  - Middle Aged
MH  - Female
MH  - Treatment Outcome
MH  - Quality of Life
MH  - *Ventricular Premature Complexes/surgery
MH  - Electrocardiography
MH  - *Heart Failure/complications
MH  - *Catheter Ablation
OTO - NOTNLM
OT  - Echocardiography
OT  - Functional class
OT  - Outflow tract
OT  - Premature ventricular complex
OT  - Quality of life
EDAT- 2022/06/23 06:00
MHDA- 2023/03/04 06:00
CRDT- 2022/06/22 11:28
PHST- 2022/04/07 00:00 [received]
PHST- 2022/05/31 00:00 [accepted]
PHST- 2022/06/23 06:00 [pubmed]
PHST- 2023/03/04 06:00 [medline]
PHST- 2022/06/22 11:28 [entrez]
AID - 10.1007/s10840-022-01264-3 [pii]
AID - 10.1007/s10840-022-01264-3 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2023 Mar;66(2):363-372. doi: 
      10.1007/s10840-022-01264-3. Epub 2022 Jun 22.