PMID- 35731440
OWN - NLM
STAT- MEDLINE
DCOM- 20221028
LR  - 20221028
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 53
DP  - 2022 Nov
TI  - The association between hearing threshold and urinary personal care and consumer 
      product metabolites in middle-aged and elderly people from the USA.
PG  - 81076-81086
LID - 10.1007/s11356-022-21459-5 [doi]
AB  - Endocrine disruptors have been reported to be associated with hearing ability. 
      However, the association between personal care and consumer product chemicals, 
      known as commonly detected endocrine disruptors, and age-related hearing loss 
      still remains unclear. This study aimed to examine the association between 
      exposure to 7 personal care and consumer product chemicals and hearing thresholds 
      in middle-aged and elderly people. A 
      nationally representative cross-sectional study was performed. Eight hundred 
      forty-five adults aged over 45 from the National Health and Nutrition Examination 
      Survey (NHANES) were included in this study. Bayesian kernel machine regression 
      (BKMR) and the k-medoid cluster analysis were used to evaluate the mixture effect 
      of exposure to 7 chemicals on pure-tone average (PTA). Exposure to these 
      chemicals was negatively associated with PTA. 2,5-Dichlorophenol had the greatest 
      contribution to the mixture effect. The mixture effect was stronger in women, 
      elderly people. Four pooled clusters were identified according to 7 chemicals 
      exposures. Cluster 4 (high TCS exposure) showed a lower HFPTA (P = 0.00258) than 
      cluster 3 (the lowest exposure cluster, as a reference). Our study provides 
      evidence that exposure to personal care and consumer product chemicals might be 
      inversely associated with PTA. More studies are needed to fully understand the 
      association of exposure to these chemicals with hearing threshold.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Fu, Yan-Peng
AU  - Fu YP
AUID- ORCID: 0000-0002-0821-4754
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated 
      Hospital of Nanchang University, No.1 Minde Road, Nanchang, China.
FAU - Chen, Wen-Yu
AU  - Chen WY
AD  - Interventional Cardiology Department, Second Affiliated Hospital of Nanchang 
      University, No.1 Minde Road, Nanchang, China.
FAU - Guo, Li-Qing
AU  - Guo LQ
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated 
      Hospital of Nanchang University, No.1 Minde Road, Nanchang, China.
FAU - Zhu, Ya-Qiong
AU  - Zhu YQ
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated 
      Hospital of Nanchang University, No.1 Minde Road, Nanchang, China.
FAU - Yuan, Jia-Sheng
AU  - Yuan JS
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated 
      Hospital of Nanchang University, No.1 Minde Road, Nanchang, China.
FAU - Liu, Yue-Hui
AU  - Liu YH
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated 
      Hospital of Nanchang University, No.1 Minde Road, Nanchang, China. 
      Liuyuehuindefy@21cn.com.
LA  - eng
PT  - Journal Article
DEP - 20220622
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Endocrine Disruptors)
SB  - IM
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - Humans
MH  - Female
MH  - *Endocrine Disruptors
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Cross-Sectional Studies
MH  - Hearing
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Cluster analysis
OT  - Hearing
OT  - Personal care and consumer product chemicals
EDAT- 2022/06/23 06:00
MHDA- 2022/10/29 06:00
CRDT- 2022/06/22 11:31
PHST- 2022/04/26 00:00 [received]
PHST- 2022/06/10 00:00 [accepted]
PHST- 2022/06/23 06:00 [pubmed]
PHST- 2022/10/29 06:00 [medline]
PHST- 2022/06/22 11:31 [entrez]
AID - 10.1007/s11356-022-21459-5 [pii]
AID - 10.1007/s11356-022-21459-5 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Nov;29(53):81076-81086. doi: 
      10.1007/s11356-022-21459-5. Epub 2022 Jun 22.