PMID- 35732285 OWN - NLM STAT- MEDLINE DCOM- 20220624 LR - 20230702 IS - 1833-3516 (Print) IS - 2209-1491 (Electronic) IS - 1833-3516 (Linking) VI - 52 IP - 2 DP - 2022 Jun 30 TI - Efficacy and safety of hyperbaric oxygen treatment to treat COVID-19 pneumonia: a living systematic review update. PG - 126-135 LID - 10.28920/dhm52.2.126-135 [doi] AB - INTRODUCTION: As the COVID-19 pandemic evolves, new effective treatment options are essential for reducing morbidity and mortality as well as the strain placed on the healthcare system. Since publication of our initial review on hyperbaric oxygen treatment (HBOT) for hypoxaemic COVID-19 patients, interest in HBOT for COVID-19 has grown and additional studies have been published. METHODS: For this living systematic review update the previously published search strategy (excluding Google Scholar) was adopted with an extension from 01 February 2021 to 01 April 2022. Study inclusion criteria, data extraction, risk of bias estimation and dispute resolution methods were repeated. RESULTS: Two new studies enrolling 127 patients were included in this update, taking the total to eight studies with 224 patients. Both new studies were randomised controlled trials, one at moderate and one at high risk of bias. Across these eight studies, 114 patients were treated with HBOT. All reported improved clinical outcomes without observation of any serious adverse events. Meta-analysis remained unjustified given the high heterogeneity between studies and incomplete reporting. CONCLUSIONS: This updated living systematic review provides further evidence on the safety and effectiveness of HBOT to treat acute hypoxaemic COVID-19 patients. CI - Copyright: This article is the copyright of the authors who grant Diving and Hyperbaric Medicine a non-exclusive licence to publish the article in electronic and other forms. FAU - Boet, Sylvain AU - Boet S AD - Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Canada. AD - Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada. AD - Francophone Affairs, Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - Corresponding author: Dr Sylvain Boet, Department of Anesthesiology and Pain Medicine, Hyperbaric Medicine Unit, The Ottawa Hospital, 501 Smyth Rd, Critical Care Wing 1401, Ottawa, K1H 8L6, Ontario, Canada, sboet@toh.ca. FAU - Etherington, Cole AU - Etherington C AD - Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Ghanmi, Nibras AU - Ghanmi N AD - Department of Public Health Sciences, Faculty of Health Sciences, Queens University, Ontario, Canada. FAU - Ioudovski, Paul AU - Ioudovski P AD - Department of Public Health Sciences, Faculty of Health Sciences, Queens University, Ontario, Canada. FAU - Tricco, Andrea C AU - Tricco AC AD - Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada. AD - Epidemiology Division and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - Queen's Collaboration for Health Care Quality: A JBI Centre of Excellence, Ontario, Canada. FAU - Sikora, Lindsey AU - Sikora L AD - Sciences Library, University of Ottawa, Ottawa, Canada. FAU - Katznelson, Rita AU - Katznelson R AD - Department of Anesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada. LA - eng PT - Systematic Review PL - Australia TA - Diving Hyperb Med JT - Diving and hyperbaric medicine JID - 101282742 RN - S88TT14065 (Oxygen) SB - IM MH - *COVID-19/therapy MH - Humans MH - *Hyperbaric Oxygenation/adverse effects MH - Oxygen MH - Pandemics MH - Treatment Outcome PMC - PMC9522603 OTO - NOTNLM OT - Hyperbaric medicine OT - Hypoxia OT - Infection OT - SARS-CoV-2 COIS- Acknowledgements George Djaiani, MD, for his contributions to the original systematic review. Conflict of interest and funding Dr Tricco was funded by a Tier 2 Canada Research Chair in Knowledge Synthesis. Dr Boet was supported by The Ottawa Hospital Anesthesia Alternate Funds Association and the Faculty of Medicine, University of Ottawa with a Tier 2 Clinical Research Chair. No conflicts of interest were declared. EDAT- 2022/06/23 06:00 MHDA- 2022/06/25 06:00 PMCR- 2023/06/30 CRDT- 2022/06/22 19:52 PHST- 2022/04/14 00:00 [received] PHST- 2022/05/20 00:00 [accepted] PHST- 2022/06/22 19:52 [entrez] PHST- 2022/06/23 06:00 [pubmed] PHST- 2022/06/25 06:00 [medline] PHST- 2023/06/30 00:00 [pmc-release] AID - 10.28920/dhm52.2.126-135 [doi] PST - ppublish SO - Diving Hyperb Med. 2022 Jun 30;52(2):126-135. doi: 10.28920/dhm52.2.126-135.