PMID- 35733036
OWN - NLM
STAT- MEDLINE
DCOM- 20220624
LR  - 20230307
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 2492
DP  - 2022
TI  - Cells of the Blood-Brain Barrier: An Overview of the Neurovascular Unit in Health 
      and Disease.
PG  - 3-24
LID - 10.1007/978-1-0716-2289-6_1 [doi]
AB  - The brain is endowed with highly specialized vasculature that is both 
      structurally and functionally unique compared to vasculature supplying peripheral 
      organs. The blood-brain barrier (BBB) is formed by endothelial cells of the 
      cerebral vasculature and prevents extravasation of blood products into the brain 
      to protect neural tissue and maintain a homeostatic environment. The BBB 
      functions as part of the neurovascular unit (NVU), which is composed of neurons, 
      astrocytes, and microglia in addition to the specialized endothelial cells, mural 
      cells, and the basement membrane. Through coordinated intercellular signaling, 
      these cells function as a dynamic unit to tightly regulate brain blood flow, 
      vascular function, neuroimmune responses, and waste clearance. In this chapter, 
      we review the functions of individual NVU components, describe neurovascular 
      coupling as a classic example of NVU function, and discuss archetypal NVU 
      pathophysiology during disease.
CI  - (c) 2022. The Author(s), under exclusive license to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - McConnell, Heather L
AU  - McConnell HL
AD  - Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health 
      & Science University, Portland, OR, USA.
AD  - Office of Academic Development, Houston Methodist Research Institute, Houston, 
      TX, USA.
FAU - Mishra, Anusha
AU  - Mishra A
AD  - Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health 
      & Science University, Portland, OR, USA. mishraa@ohsu.edu.
AD  - Knight Cardiovascular Institute, Oregon Health & Science University, Portland, 
      OR, USA. mishraa@ohsu.edu.
LA  - eng
GR  - P30 AG066518/AG/NIA NIH HHS/United States
GR  - R01 DA047237/DA/NIDA NIH HHS/United States
GR  - R01 NS110690/NS/NINDS NIH HHS/United States
GR  - T32 HL094294/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Astrocytes/physiology
MH  - Biological Transport
MH  - *Blood-Brain Barrier/physiology
MH  - Brain
MH  - *Endothelial Cells/physiology
PMC - PMC9987262
MID - NIHMS1831314
OTO - NOTNLM
OT  - Astrogliosis
OT  - Blood-brain barrier
OT  - Cerebral blood flow
OT  - Neurovascular coupling
OT  - Neurovascular unit
EDAT- 2022/06/23 06:00
MHDA- 2022/06/25 06:00
PMCR- 2023/03/06
CRDT- 2022/06/22 23:34
PHST- 2022/06/22 23:34 [entrez]
PHST- 2022/06/23 06:00 [pubmed]
PHST- 2022/06/25 06:00 [medline]
PHST- 2023/03/06 00:00 [pmc-release]
AID - 10.1007/978-1-0716-2289-6_1 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2022;2492:3-24. doi: 10.1007/978-1-0716-2289-6_1.