PMID- 35733642
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - The Role of Changes in Cumulative Lipid Parameter Burden in the Pathogenesis of 
      Type 2 Diabetes Mellitus: A Cohort Study of People Aged 35-65 Years in Rural 
      China.
PG  - 1831-1843
LID - 10.2147/DMSO.S363692 [doi]
AB  - PURPOSE: The main purpose of this study was to examine the effect of the 
      cumulative exposure of blood lipid parameters on type 2 diabetes mellitus (T2DM). 
      Another purpose was to explore whether the cumulative burden of blood lipid 
      parameters plays a certain role in the pathogenesis of diet affecting T2DM. 
      PATIENTS AND METHODS: A total of 63 cases of diabetes occurred from 2017 to 2020, 
      with an incidence density of 3.71 person-years. The dietary intake of the 
      residents was obtained by using a dietary frequency questionnaire (FFQ). 
      Cumulative lipid parameter burden was calculated according to the number of years 
      (2016-2020) multiplied by total cholesterol (TC), high density lipoprotein (HDL), 
      low density lipoprotein (LDL) and triglyceride (TG). A Cox proportional hazard 
      model was used to estimate the effect of cumulative lipid burden on T2DM. A 
      mediating analysis of accelerated failure time (AFT) was used to investigate the 
      mediating effects of certain foods, the cumulative lipid parameter burden and 
      T2DM. RESULTS: A higher cumulative TG load corresponded to a higher risk of T2DM 
      onset (P(trend) =0.021). After adjusting for covariates, the highest quartile 
      cumulative TG burden had a 3.462 times higher risk of T2DM than that in the 
      lowest quartile (HR=3.462, 95% CI: 1.297-9.243). Moreover, a higher cumulative 
      HDL load corresponded to a lower risk of T2DM onset (P(trend) =0.006). After 
      adjusting for covariates, the risk of T2DM was 0.314-fold lower in the highest 
      quartile of cumulative HDL burden than that in the lowest quartile (HR=0.314, 95% 
      CI: 0.131-0.753). Cumulative TG burden partially mediated the association between 
      red meat and T2DM. CONCLUSION: The increase in cumulative HDL burden and the 
      decrease in cumulative HDL burden are related to the incidence of T2DM. 
      Cumulative TG burden was shown to play a partial mediating role in the 
      pathogenesis of red meat and diabetes.
CI  - (c) 2022 Wang et al.
FAU - Wang, Qi
AU  - Wang Q
AD  - Key Laboratory of Cardio Cerebrovascular Diseases, Ministry of Education, Gannan 
      Medical University, Ganzhou, People's Republic of China.
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
FAU - Xie, Tao
AU  - Xie T
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
FAU - Deng, Yuanjia
AU  - Deng Y
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
FAU - Zhang, Yuying
AU  - Zhang Y
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
FAU - Wu, Qingfeng
AU  - Wu Q
AD  - Key Laboratory of Cardio Cerebrovascular Diseases, Ministry of Education, Gannan 
      Medical University, Ganzhou, People's Republic of China.
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
FAU - Dong, Minghua
AU  - Dong M
AD  - Key Laboratory of Cardio Cerebrovascular Diseases, Ministry of Education, Gannan 
      Medical University, Ganzhou, People's Republic of China.
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
FAU - Luo, Xiaoting
AU  - Luo X
AD  - Key Laboratory of Cardio Cerebrovascular Diseases, Ministry of Education, Gannan 
      Medical University, Ganzhou, People's Republic of China.
AD  - School of Public Health and Health Management, Gannan Medical University, 
      Ganzhou, People's Republic of China.
AD  - School of General Medicine, Gannan Medical University, Ganzhou, People's Republic 
      of China.
LA  - eng
PT  - Journal Article
DEP - 20220616
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC9208634
OTO - NOTNLM
OT  - cohort study
OT  - cumulative lipid parameter burden
OT  - diet
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2022/06/24 06:00
MHDA- 2022/06/24 06:01
PMCR- 2022/06/16
CRDT- 2022/06/23 02:26
PHST- 2022/02/23 00:00 [received]
PHST- 2022/06/03 00:00 [accepted]
PHST- 2022/06/23 02:26 [entrez]
PHST- 2022/06/24 06:00 [pubmed]
PHST- 2022/06/24 06:01 [medline]
PHST- 2022/06/16 00:00 [pmc-release]
AID - 363692 [pii]
AID - 10.2147/DMSO.S363692 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 Jun 16;15:1831-1843. doi: 10.2147/DMSO.S363692. 
      eCollection 2022.