PMID- 35733780
OWN - NLM
STAT- MEDLINE
DCOM- 20220624
LR  - 20220728
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal 
      Glucose, Insulin and C-peptide Kinetics.
PG  - 868364
LID - 10.3389/fendo.2022.868364 [doi]
LID - 868364
AB  - BACKGROUND: The MTNR1B gene encodes a receptor for melatonin, a hormone 
      regulating biorhythms. Disruptions in biorhythms contribute to the development of 
      type 2 diabetes mellitus (T2DM). Genetic studies suggest that variability in the 
      MTNR1B gene affects T2DM development. Our aim was to compare the distribution of 
      the genetic variant rs10830963 between persons differing in glucose tolerance in 
      a sample of the Czech population (N=1206). We also evaluated possible 
      associations of the polymorphism with insulin sensitivity, beta cell function, 
      with the shape of glucose, insulin and C-peptide trajectories measured 7 times 
      during a 3-hour oral glucose tolerance test (OGTT) and with glucagon response. In 
      a subgroup of 268 volunteers we also evaluated sleep patterns and biorhythm. 
      RESULTS: 13 persons were diagnosed with T2DM, 119 had impaired fasting blood 
      glucose (IFG) and/or impaired glucose tolerance (IGT). 1074 participants showed 
      normal results and formed a control group. A higher frequency of minor allele G 
      was found in the IFG/IGT group in comparison with controls. The GG constellation 
      was present in 23% of diabetics, in 17% of IFG/IGT probands and in 11% of 
      controls. Compared to CC and CG genotypes, GG homozygotes showed higher 
      stimulated glycemia levels during the OGTT. Homozygous as well as heterozygous 
      carriers of the G allele showed lower very early phase of insulin and C-peptide 
      secretion with unchanged insulin sensitivity. These differences remained 
      significant after excluding diabetics and the IFG/IGT group from the analysis. No 
      associations of the genotype with the shape of OGTT-based trajectories, with 
      glucagon or with chronobiological patterns were observed. However, the shape of 
      the trajectories differed significantly between men and women. CONCLUSION: In a 
      representative sample of the Czech population, the G allele of the rs10830963 
      polymorphism is associated with impaired early phase of beta cell function, and 
      this is evident even in healthy individuals.
CI  - Copyright (c) 2022 Vejrazkova, Vankova, Vcelak, Krejci, Anderlova, Tura, Pacini, 
      Sumova, Sladek and Bendlova.
FAU - Vejrazkova, Daniela
AU  - Vejrazkova D
AD  - Department of Molecular Endocrinology, Institute of Endocrinology, Prague, 
      Czechia.
FAU - Vankova, Marketa
AU  - Vankova M
AD  - Department of Molecular Endocrinology, Institute of Endocrinology, Prague, 
      Czechia.
FAU - Vcelak, Josef
AU  - Vcelak J
AD  - Department of Molecular Endocrinology, Institute of Endocrinology, Prague, 
      Czechia.
FAU - Krejci, Hana
AU  - Krejci H
AD  - Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles 
      University and General University Hospital in Prague, Prague, Czechia.
FAU - Anderlova, Katerina
AU  - Anderlova K
AD  - Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles 
      University and General University Hospital in Prague, Prague, Czechia.
FAU - Tura, Andrea
AU  - Tura A
AD  - Metabolic Unit, Institute of Neuroscience, National Research Council, Padova, 
      Italy.
FAU - Pacini, Giovanni
AU  - Pacini G
AD  - Metabolic Unit, Institute of Neuroscience, National Research Council, Padova, 
      Italy.
FAU - Sumova, Alena
AU  - Sumova A
AD  - Laboratory of Biological Rhythms, Institute of Physiology of the Czech Academy of 
      Sciences, Prague, Czechia.
FAU - Sladek, Martin
AU  - Sladek M
AD  - Laboratory of Biological Rhythms, Institute of Physiology of the Czech Academy of 
      Sciences, Prague, Czechia.
FAU - Bendlova, Bela
AU  - Bendlova B
AD  - Department of Molecular Endocrinology, Institute of Endocrinology, Prague, 
      Czechia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220606
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Insulin)
RN  - 0 (MTNR1B protein, human)
RN  - 0 (Receptor, Melatonin, MT2)
RN  - 9007-92-5 (Glucagon)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Blood Glucose
MH  - C-Peptide
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Female
MH  - Glucagon
MH  - Glucose
MH  - *Glucose Intolerance/epidemiology/genetics
MH  - Humans
MH  - Insulin
MH  - *Insulin Resistance/genetics
MH  - Kinetics
MH  - Male
MH  - *Prediabetic State
MH  - *Receptor, Melatonin, MT2/genetics
PMC - PMC9207528
OTO - NOTNLM
OT  - MTNR1B gene
OT  - OGTT trajectories
OT  - beta cell function
OT  - glucose tolerance
OT  - insulin sensitivity
OT  - rs10830963
OT  - type 2 daibetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/24 06:00
MHDA- 2022/06/25 06:00
PMCR- 2022/01/01
CRDT- 2022/06/23 02:28
PHST- 2022/02/03 00:00 [received]
PHST- 2022/04/25 00:00 [accepted]
PHST- 2022/06/23 02:28 [entrez]
PHST- 2022/06/24 06:00 [pubmed]
PHST- 2022/06/25 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.868364 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jun 6;13:868364. doi: 
      10.3389/fendo.2022.868364. eCollection 2022.