PMID- 35735819
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2308-3425 (Electronic)
IS  - 2308-3425 (Linking)
VI  - 9
IP  - 6
DP  - 2022 Jun 12
TI  - A Cease in Shift Work Reverses Arterial Stiffness but Increases Weight and 
      Glycosylated Hemoglobin A 5-Month Follow-Up in Industry.
LID - 10.3390/jcdd9060190 [doi]
LID - 190
AB  - BACKGROUND: Literature suggests an association between shift work and 
      cardiovascular disease (CVD). Limited evidence is available on how a cessation of 
      shift work affects CVD risk factors. AIM: We investigated whether a five-month 
      plant shutdown affected CVD risk factors in 30 industrial shift workers. METHODS: 
      We collected demographic data, self-reported data on physical activity (PA) and 
      medical history by questionnaire. Pre- and post-plant shutdown, we measured blood 
      pressure (BP), heart rate, lipids, glycosylated hemoglobin (HbA1c) and C-reactive 
      protein (CRP). Additionally, we collected markers of inflammation, Matrix 
      metalloproteinase-9 (MMP-9), Interleukin-6 (IL-6), Monocyte chemoattractant 
      protein-1 (MCP-1), Tumor necrosis factor-alpha (TNF-alpha), P-selectin, Interleukin-1 
      beta (IL-1beta), and Interleukin-23 (IL-23). We also examined arterial stiffness 
      (central blood pressure, augmentation pressure, and pulse wave velocity) by means 
      of SphygmoCor((R)) (AtCor Medical Pty Ltd., Sydney, Australia). We monitored sleep 
      by actigraphy prior to and after plant shutdown, with additional registration of 
      sleep quality and assessment of insomnia symptoms. RESULTS: After five months of 
      plant shutdown, we found that HbA1c increased by 1.9 mmol/mol, weight by 1 kg and 
      MCP-1 by 27.3 pg/mL, all unexpectedly. The other markers of inflammation did not 
      change during shutdown, but CRP decreased close to significant levels. There were 
      no changes in lipids during follow-up. Pulse-wave velocity (PWV) was reduced from 
      8.1 m/s (SD = 1.5) to 7.6 m/s (SD = 1.5), p = 0.03. The workers reported fewer 
      signs of insomnia after shutdown. CONCLUSIONS: Our findings suggest that a 
      five-month cessation in shift work increases weight and HbA1c, but also improves 
      insomnia symptoms and reverses arterial stiffening.
FAU - Skogstad, Marit
AU  - Skogstad M
AD  - National Institute of Occupational Health (STAMI), Box 5330 Majorstuen, 0304 
      Oslo, Norway.
FAU - Aass, Hans Christian D
AU  - Aass HCD
AD  - The Blood Cell Research Group, Department of Medical Biochemistry, Oslo 
      University Hospital, 0450 Oslo, Norway.
FAU - Lunde, Lars-Kristian
AU  - Lunde LK
AUID- ORCID: 0000-0001-6219-9244
AD  - National Institute of Occupational Health (STAMI), Box 5330 Majorstuen, 0304 
      Oslo, Norway.
FAU - Skare, Oivind
AU  - Skare O
AUID- ORCID: 0000-0001-8043-2820
AD  - National Institute of Occupational Health (STAMI), Box 5330 Majorstuen, 0304 
      Oslo, Norway.
FAU - Sirnes, Per Anton
AU  - Sirnes PA
AD  - Ostlandske Hjertesenter, 1523 Moss, Norway.
FAU - Matre, Dagfinn
AU  - Matre D
AUID- ORCID: 0000-0003-0042-6389
AD  - National Institute of Occupational Health (STAMI), Box 5330 Majorstuen, 0304 
      Oslo, Norway.
LA  - eng
GR  - No number/Industri Energi and LO Norway/
PT  - Journal Article
DEP - 20220612
PL  - Switzerland
TA  - J Cardiovasc Dev Dis
JT  - Journal of cardiovascular development and disease
JID - 101651414
PMC - PMC9224692
OTO - NOTNLM
OT  - arterial stiffening
OT  - cardiovascular
OT  - occupational health
OT  - shift work
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/24 06:00
MHDA- 2022/06/24 06:01
PMCR- 2022/06/12
CRDT- 2022/06/23 08:53
PHST- 2022/05/10 00:00 [received]
PHST- 2022/06/07 00:00 [revised]
PHST- 2022/06/08 00:00 [accepted]
PHST- 2022/06/23 08:53 [entrez]
PHST- 2022/06/24 06:00 [pubmed]
PHST- 2022/06/24 06:01 [medline]
PHST- 2022/06/12 00:00 [pmc-release]
AID - jcdd9060190 [pii]
AID - jcdd-09-00190 [pii]
AID - 10.3390/jcdd9060190 [doi]
PST - epublish
SO  - J Cardiovasc Dev Dis. 2022 Jun 12;9(6):190. doi: 10.3390/jcdd9060190.