PMID- 35737314
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2306-7381 (Electronic)
IS  - 2306-7381 (Linking)
VI  - 9
IP  - 6
DP  - 2022 May 31
TI  - Overweight Management through Mild Caloric Restriction in Multigenerational 
      Long-Tailed Macaque Breeding Groups.
LID - 10.3390/vetsci9060262 [doi]
LID - 262
AB  - Caloric restriction (CR) is an effective method to reduce overweight in captive 
      non-human primates (NHPs). CR has been applied to individually- and pair-housed 
      NHPs, but whether applying CR can be effective and safe in group-housed NHPs has 
      not yet been assessed. This study investigates the effect of mild (20%) CR on 
      adult overweight and biochemical parameters, immature growth, veterinary 
      consultations, and reproductive success in multigenerational long-tailed macaque 
      (Macaca fascicularis) breeding groups. Data were derived from anthropometric 
      measurements and blood samples during yearly health checks, complemented with 
      retrospective data on veterinary consultations and reproductive success. Adult 
      body measures decreased after CR, with heavier individuals and females losing 
      more weight compared to leaner individuals and males. CR lowered cholesterol 
      levels in adults but had no overall effect on other biochemical parameters. Yet, 
      biochemical parameters of individuals with high baseline values were reduced more 
      compared to individuals with low baseline values. Immature growth, veterinary 
      consultations and reproductive success were not influenced by CR. Thus, CR 
      targeted the right individuals, i.e., overweight adults, and had no adverse 
      effects on the variables examined in this study. This implies that mild CR can be 
      a valuable overweight management strategy in group-housed NHPs.
FAU - Zijlmans, Dian G M
AU  - Zijlmans DGM
AUID- ORCID: 0000-0001-7318-9711
AD  - Animal Science Department, Biomedical Primate Research Centre, 2288 GJ Rijswijk, 
      The Netherlands.
AD  - Animal Behaviour and Cognition, Department of Biology, Utrecht University, 3508 
      TB Utrecht, The Netherlands.
FAU - Maaskant, Annemiek
AU  - Maaskant A
AUID- ORCID: 0000-0002-5385-9906
AD  - Animal Science Department, Biomedical Primate Research Centre, 2288 GJ Rijswijk, 
      The Netherlands.
AD  - Department Population Health Sciences, Unit Animals in Science and Society, 
      Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The 
      Netherlands.
FAU - Louwerse, Annet L
AU  - Louwerse AL
AD  - Animal Science Department, Biomedical Primate Research Centre, 2288 GJ Rijswijk, 
      The Netherlands.
FAU - Sterck, Elisabeth H M
AU  - Sterck EHM
AD  - Animal Science Department, Biomedical Primate Research Centre, 2288 GJ Rijswijk, 
      The Netherlands.
AD  - Animal Behaviour and Cognition, Department of Biology, Utrecht University, 3508 
      TB Utrecht, The Netherlands.
FAU - Langermans, Jan A M
AU  - Langermans JAM
AUID- ORCID: 0000-0002-4806-4412
AD  - Animal Science Department, Biomedical Primate Research Centre, 2288 GJ Rijswijk, 
      The Netherlands.
AD  - Department Population Health Sciences, Unit Animals in Science and Society, 
      Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The 
      Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20220531
PL  - Switzerland
TA  - Vet Sci
JT  - Veterinary sciences
JID - 101680127
PMC - PMC9230116
OTO - NOTNLM
OT  - dietary restriction
OT  - group-living
OT  - nutrition
OT  - obesity
OT  - reproduction
OT  - welfare
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/24 06:00
MHDA- 2022/06/24 06:01
PMCR- 2022/05/31
CRDT- 2022/06/23 11:23
PHST- 2022/05/04 00:00 [received]
PHST- 2022/05/27 00:00 [revised]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/06/23 11:23 [entrez]
PHST- 2022/06/24 06:00 [pubmed]
PHST- 2022/06/24 06:01 [medline]
PHST- 2022/05/31 00:00 [pmc-release]
AID - vetsci9060262 [pii]
AID - vetsci-09-00262 [pii]
AID - 10.3390/vetsci9060262 [doi]
PST - epublish
SO  - Vet Sci. 2022 May 31;9(6):262. doi: 10.3390/vetsci9060262.