PMID- 35738970 OWN - NLM STAT- MEDLINE DCOM- 20240205 LR - 20240205 IS - 1873-2518 (Electronic) IS - 0264-410X (Print) IS - 0264-410X (Linking) VI - 40 IP - 32 DP - 2022 Jul 30 TI - Safety and protective capability of an inactivated SARS-CoV-2 vaccine on pregnancy, lactation and the growth of offspring in hACE2 mice. PG - 4609-4616 LID - S0264-410X(22)00765-4 [pii] LID - 10.1016/j.vaccine.2022.06.020 [doi] AB - The mass inoculation of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine to induce herd immunity is one of the most effective measures to fight COVID-19. The vaccination of pregnant women cannot only avoid or reduce the probability of infectious diseases, but also offers the most effective and direct protection for neonates by means of passive immunization. However, there is no randomized clinical data to ascertain whether the inactivated vaccination of pregnant women or women of childbearing age can affect conception and the fetus. We found that human angiotensin-converting enzyme 2 (hACE2) mice that were vaccinated with two doses of CoronaVac (an inactivated SARS-CoV-2 vaccine) before and during pregnancy exhibited normal weight changes and reproductive performance indices; the physical development of their offspring was also normal. Following intranasal inoculation with SARS-CoV-2, pregnant mice in the immunization group all survived; reproductive performance indices and the physical development of offspring were all normal. In contrast, mice in the non-immunization group all died before delivery. Analyses showed that inoculation of CoronaVac was safe and did not exert any significant effects on pregnancy, lactation, or the growth of offspring in hACE2 mice. Vaccination effectively protected the pregnant mice against SARS-CoV-2 infection and had no adverse effects on the growth and development of the offspring, thus suggesting that inoculation with an inactivated SARS-CoV-2 vaccine may be an effective strategy to prevent infection in pregnant women. CI - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lin, Kaili AU - Lin K AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Liu, Meixuan AU - Liu M AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Bao, Linlin AU - Bao L AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Lv, Qi AU - Lv Q AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Zhu, Hua AU - Zhu H AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Li, Dan AU - Li D AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Xu, Yanfeng AU - Xu Y AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Xiang, Zhiguang AU - Xiang Z AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Liu, Jiangning AU - Liu J AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Liang, Xujian AU - Liang X AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Han, Yunlin AU - Han Y AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Cong, Zhe AU - Cong Z AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Liu, Ruixue AU - Liu R AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Deng, Ran AU - Deng R AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Wang, Siyuan AU - Wang S AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Guo, Zhi AU - Guo Z AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Sun, Lu AU - Sun L AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Wei, Qiang AU - Wei Q AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Qiao, Hongwei AU - Qiao H AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Wang, Shunyi AU - Wang S AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Pan, Sidan AU - Pan S AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. FAU - Gao, Hong AU - Gao H AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. Electronic address: gaoh@cnilas.org. FAU - Qin, Chuan AU - Qin C AD - Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China. Electronic address: qinchuan@pumc.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220608 PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - EC 3.4.17.23 (Angiotensin-Converting Enzyme 2) RN - 0 (COVID-19 Vaccines) RN - 0 (sinovac COVID-19 vaccine) RN - 0 (Vaccines, Inactivated) SB - IM MH - Animals MH - Female MH - Mice MH - Pregnancy MH - Angiotensin-Converting Enzyme 2 MH - *COVID-19/prevention & control MH - *COVID-19 Vaccines/adverse effects/immunology MH - *Lactation MH - Mice, Transgenic MH - SARS-CoV-2 MH - Vaccines, Inactivated PMC - PMC9174435 OTO - NOTNLM OT - Inactivated SARS-CoV-2 vaccine OT - Pregnant hACE2 mice OT - Protective capability OT - Safety COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/06/24 06:00 MHDA- 2022/07/22 06:00 PMCR- 2022/06/08 CRDT- 2022/06/23 22:05 PHST- 2021/10/09 00:00 [received] PHST- 2022/04/17 00:00 [revised] PHST- 2022/06/05 00:00 [accepted] PHST- 2022/06/24 06:00 [pubmed] PHST- 2022/07/22 06:00 [medline] PHST- 2022/06/23 22:05 [entrez] PHST- 2022/06/08 00:00 [pmc-release] AID - S0264-410X(22)00765-4 [pii] AID - 10.1016/j.vaccine.2022.06.020 [doi] PST - ppublish SO - Vaccine. 2022 Jul 30;40(32):4609-4616. doi: 10.1016/j.vaccine.2022.06.020. Epub 2022 Jun 8.