PMID- 35740032
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 6
DP  - 2022 Jun 9
TI  - NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 
      Diabetes: Current Knowledge and Therapeutic Outlook.
LID - 10.3390/antiox11061131 [doi]
LID - 1131
AB  - Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat 
      accumulation in hepatocytes, is closely linked to insulin resistance and is the 
      most frequent complication of type 2 diabetes mellitus (T2DM). One of the 
      features connecting NAFLD, insulin resistance and T2DM is cellular oxidative 
      stress. Oxidative stress refers to a redox imbalance due to an inequity between 
      the capacity of production and the elimination of reactive oxygen species (ROS). 
      One of the major cellular ROS sources is NADPH oxidase enzymes (NOX-es). In 
      physiological conditions, NOX-es produce ROS purposefully in a timely and 
      spatially regulated manner and are crucial regulators of various cellular events 
      linked to metabolism, receptor signal transmission, proliferation and apoptosis. 
      In contrast, dysregulated NOX-derived ROS production is related to the onset of 
      diverse pathologies. This review provides a synopsis of current knowledge 
      concerning NOX enzymes as connective elements between NAFLD, insulin resistance 
      and T2DM and weighs their potential relevance as pharmacological targets to 
      alleviate fatty liver disease.
FAU - Nasce, Alberto
AU  - Nasce A
AD  - Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, 
      Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, 
      Switzerland.
FAU - Gariani, Karim
AU  - Gariani K
AD  - Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, 
      Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, 
      Switzerland.
AD  - Department of Medicine, Faculty of Medicine, University of Geneva, 1211 Geneva, 
      Switzerland.
AD  - Diabetes Center of the Faculty of Medicine, University of Geneva Medical School, 
      1211 Geneva, Switzerland.
FAU - Jornayvaz, Francois R
AU  - Jornayvaz FR
AUID- ORCID: 0000-0001-9425-3137
AD  - Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, 
      Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, 
      Switzerland.
AD  - Department of Medicine, Faculty of Medicine, University of Geneva, 1211 Geneva, 
      Switzerland.
AD  - Diabetes Center of the Faculty of Medicine, University of Geneva Medical School, 
      1211 Geneva, Switzerland.
AD  - Department of Cell Physiology and Metabolism, Faculty of Medicine, University of 
      Geneva, 1211 Geneva, Switzerland.
FAU - Szanto, Ildiko
AU  - Szanto I
AUID- ORCID: 0000-0003-3566-7991
AD  - Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, 
      Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, 
      Switzerland.
AD  - Department of Medicine, Faculty of Medicine, University of Geneva, 1211 Geneva, 
      Switzerland.
AD  - Diabetes Center of the Faculty of Medicine, University of Geneva Medical School, 
      1211 Geneva, Switzerland.
LA  - eng
GR  - ISZ-1, 2017/Fondation Insuleman/
GR  - ISZ-1, 2019/Fondation pour l'innovation sur le cancer et la biologie/
GR  - 189003/SNSF_/Swiss National Science Foundation/Switzerland
PT  - Journal Article
PT  - Review
DEP - 20220609
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC9219746
OTO - NOTNLM
OT  - NADPH oxidase
OT  - NAFLD
OT  - NOX
OT  - ROS
OT  - diabetes
OT  - hepatosteatosis
OT  - insulin resistance
OT  - nonalcoholic fatty liver disease
OT  - oxidative stress
OT  - reactive oxygen species
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/06/09
CRDT- 2022/06/24 01:04
PHST- 2022/04/14 00:00 [received]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/06/03 00:00 [accepted]
PHST- 2022/06/24 01:04 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/06/09 00:00 [pmc-release]
AID - antiox11061131 [pii]
AID - antioxidants-11-01131 [pii]
AID - 10.3390/antiox11061131 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Jun 9;11(6):1131. doi: 10.3390/antiox11061131.