PMID- 35740474
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 10
IP  - 6
DP  - 2022 Jun 19
TI  - The Mediating Effect of Cytokines on the Association between Fungal Sensitization 
      and Poor Clinical Outcome in Asthma.
LID - 10.3390/biomedicines10061452 [doi]
LID - 1452
AB  - Sensitization to fungal allergens is one of the proposed phenotypes in asthma. An 
      association between fungal sensitization and worse clinical outcomes is apparent. 
      Moreover, fungal sensitization in asthma that is associated with different type 
      of immunological mechanism has been reported. How the role of cytokines mediates 
      the association between fungal sensitization and poorer asthmatic outcomes 
      remains unclear. We aimed to determine role of cytokines in the relationship 
      between fungal sensitization and worse clinical outcomes in asthma. METHOD: We 
      conducted a prospective study to recruit adult patients with asthma. Data 
      including age, sex, height, weight, smoking history, medication, emergency visit 
      and admission, pulmonary function testing result, and Asthma Control Test (ACT) 
      scores were collected. We used the automated BioIC method to measure fungal 
      allergen sIgE in sera. Serum levels of Interleukin (IL) -4, IL-13, IL-6, IL-9, 
      IL-10, IL-17 A, IL-22, Interferon (IFN) -gamma, Immunoglobulin E (IgE), Tumor 
      necrosis factor-alpha (TNF-alpha), and Transforming growth factor-beta (TGF-beta) were measured 
      using ELISA. RESULT: IL-6 and IL-17A had a significant positive correlation 
      between sensitization and most fungi species compared to IgE. Sensitization to 
      Candida albicans had strongly positive association both with IL-6 and IL-17A. 
      However, only IL-17A had significant relationship with ED visit times. The 
      mediation analysis result indicates that IL-17A had a significant positively 
      mediating effect (ME) on the association between Candida albicans and ED visit 
      times. CONCLUSION: IL-17A is a potential mediator to link Candida albicans 
      sensitization and ED visits for asthma. We suggest that patients with fungal 
      sensitization, such as Candida albicans, have poorer outcomes associated with 
      Th17-mediated immune response rather than Th2.
FAU - Lin, Ching-Hsiung
AU  - Lin CH
AUID- ORCID: 0000-0001-9407-8578
AD  - Division of Chest Medicine, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua 500, Taiwan.
AD  - Institute of Genomics and Bioinformatics, National Chung Hsing University, 
      Taichung 402, Taiwan.
AD  - Ph.D. Program in Translational Medicine, National Chung Hsing University, 
      Taichung 402, Taiwan.
AD  - Department of Recreation and Holistic Wellness, MingDao University, Changhua 523, 
      Taiwan.
FAU - Li, Yi-Rong
AU  - Li YR
AD  - Thoracic Medicine Research Center, Changhua Christian Hospital, Changhua 500, 
      Taiwan.
FAU - Kor, Chew-Teng
AU  - Kor CT
AD  - Big Data Center, Changhua Christian Hospital, Changhua 500, Taiwan.
AD  - Graduate Institute of Statistics and Information Science, National Changhua 
      University of Education, Changhua 500, Taiwan.
FAU - Lin, Sheng-Hao
AU  - Lin SH
AD  - Division of Chest Medicine, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua 500, Taiwan.
AD  - Department of Recreation and Holistic Wellness, MingDao University, Changhua 523, 
      Taiwan.
AD  - Thoracic Medicine Research Center, Changhua Christian Hospital, Changhua 500, 
      Taiwan.
FAU - Ji, Bin-Chuan
AU  - Ji BC
AD  - Division of Chest Medicine, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua 500, Taiwan.
FAU - Lin, Ming-Tai
AU  - Lin MT
AD  - Division of Chest Medicine, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua 500, Taiwan.
FAU - Chai, Woei-Horng
AU  - Chai WH
AD  - Division of Chest Medicine, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua 500, Taiwan.
LA  - eng
GR  - 110-CCH-MST-122/Changhua Christian Hospital/
PT  - Journal Article
DEP - 20220619
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9220002
OTO - NOTNLM
OT  - Candida albicans
OT  - IL-17A
OT  - asthma
OT  - fungal sensitization
OT  - mediation effect
COIS- All authors declare no conflict of interest related to the data collected and 
      procedures in this study.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/06/19
CRDT- 2022/06/24 01:06
PHST- 2022/06/02 00:00 [received]
PHST- 2022/06/16 00:00 [revised]
PHST- 2022/06/17 00:00 [accepted]
PHST- 2022/06/24 01:06 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/06/19 00:00 [pmc-release]
AID - biomedicines10061452 [pii]
AID - biomedicines-10-01452 [pii]
AID - 10.3390/biomedicines10061452 [doi]
PST - epublish
SO  - Biomedicines. 2022 Jun 19;10(6):1452. doi: 10.3390/biomedicines10061452.