PMID- 35741130
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 12
IP  - 6
DP  - 2022 May 26
TI  - Effects of Lower Limb Revascularization on the Microcirculation of the Foot: A 
      Retrospective Cohort Study.
LID - 10.3390/diagnostics12061320 [doi]
LID - 1320
AB  - Background: Current assessment standards in chronic limb-threatening ischemia 
      (CLTI) focus on macrovascular function while neglecting the microcirculation. 
      Multispectral near-infrared spectroscopy (NIRS) provides hemodynamic 
      characteristics of the microcirculation (i.e., capillaries) and may be a powerful 
      tool for monitoring CLTI and preventing extremity loss. The aims of this study 
      were to (1) investigate the effects of lower limb revascularization on the 
      microcirculation and (2) determine if macrovascular and microvascular assessments 
      correlate. Methods: An observational, retrospective cohort study of 38 
      endovascular interventions in 30 CLTI subjects was analyzed pre- and 
      post-intervention for arterial Doppler acceleration times (AcT; macrovascular) 
      and NIRS metrics (microvascular). Pre-intervention ankle-brachial index (ABI) was 
      also analyzed. Results: AcT significantly decreased (p = 0.009) while 
      oxyhemoglobin (HbO) significantly increased (p < 0.04) after endovascular 
      intervention, indicating treatment efficacy. However, macrovascular measurements 
      (ABI, AcT) and NIRS metrics of oxygenation and perfusion did not correlate (p > 
      0.06, r2 < 0.15, n = 23) indicating that macro- and microvascular assessment are 
      not congruent. Conclusion: These findings suggest that macrovascular and 
      microvascular assessments can determine interventional efficacy in their 
      corresponding vasculature. Their lack of correlation, however, suggests the need 
      for simultaneous assessment as independent use may cause diagnostic information 
      to be missed.
FAU - Geskin, Gennady
AU  - Geskin G
AD  - Greater Pittsburgh Vascular Associates, Pittsburgh, PA 15025, USA.
FAU - Mulock, Michael D
AU  - Mulock MD
AD  - Greater Pittsburgh Vascular Associates, Pittsburgh, PA 15025, USA.
FAU - Tomko, Nicole L
AU  - Tomko NL
AD  - Greater Pittsburgh Vascular Associates, Pittsburgh, PA 15025, USA.
FAU - Dasta, Anna
AU  - Dasta A
AD  - Greater Pittsburgh Vascular Associates, Pittsburgh, PA 15025, USA.
FAU - Gopalakrishnan, Sandeep
AU  - Gopalakrishnan S
AD  - College of Nursing, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
LA  - eng
PT  - Journal Article
DEP - 20220526
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9221918
OTO - NOTNLM
OT  - chronic limb-threatening ischemia
OT  - macrovasculature
OT  - microcirculation
OT  - microvasculature
OT  - oxygenation
OT  - perfusion
OT  - revascularization
COIS- The authors report no financial relationships or conflict of interest.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/05/26
CRDT- 2022/06/24 01:10
PHST- 2022/04/14 00:00 [received]
PHST- 2022/05/18 00:00 [revised]
PHST- 2022/05/22 00:00 [accepted]
PHST- 2022/06/24 01:10 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/05/26 00:00 [pmc-release]
AID - diagnostics12061320 [pii]
AID - diagnostics-12-01320 [pii]
AID - 10.3390/diagnostics12061320 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2022 May 26;12(6):1320. doi: 10.3390/diagnostics12061320.