PMID- 35741452
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2079-7737 (Print)
IS  - 2079-7737 (Electronic)
IS  - 2079-7737 (Linking)
VI  - 11
IP  - 6
DP  - 2022 Jun 19
TI  - Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier 
      Formation.
LID - 10.3390/biology11060931 [doi]
LID - 931
AB  - The skin epidermis, with its capacity for lifelong self-renewal and rapid 
      repairing response upon injury, must maintain an active status in metabolism. 
      Mechanistic target of rapamycin (mTOR) signaling is a central controller of 
      cellular growth and metabolism that coordinates diverse physiological and 
      pathological processes in a variety of tissues and organs. Recent evidence with 
      genetic mouse models highlights an essential role of the mTOR signaling network 
      in epidermal morphogenesis and barrier formation. In this review, we focus on the 
      recent advances in understanding how mTOR signaling networks, including upstream 
      inputs, kinases and downstream effectors, regulate epidermal morphogenesis and 
      skin barrier formation. Understanding the details of the metabolic signaling will 
      be critical for the development of novel pharmacological approaches to promote 
      skin barrier regeneration and to treat epidermal barrier defect-associated 
      diseases.
FAU - Wang, Juan
AU  - Wang J
AUID- ORCID: 0000-0003-4440-9302
AD  - Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of 
      Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, 
      Shanghai University, Nantong 226011, China.
AD  - Shanghai Engineering Research Center of Organ Repair, School of Medicine, 
      Shanghai University, Shanghai 200444, China.
FAU - Eming, Sabine A
AU  - Eming SA
AD  - Department of Dermatology, University of Cologne, 50937 Cologne, Germany.
AD  - Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated 
      Diseases (CECAD), University of Cologne, 50674 Cologne, Germany.
AD  - Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 
      Cologne, Germany.
AD  - Institute of Zoology, Developmental Biology Unit, University of Cologne, 50674 
      Cologne, Germany.
FAU - Ding, Xiaolei
AU  - Ding X
AD  - Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of 
      Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, 
      Shanghai University, Nantong 226011, China.
AD  - Shanghai Engineering Research Center of Organ Repair, School of Medicine, 
      Shanghai University, Shanghai 200444, China.
AD  - Department of Dermatology, University of Cologne, 50937 Cologne, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220619
PL  - Switzerland
TA  - Biology (Basel)
JT  - Biology
JID - 101587988
PMC - PMC9220260
OTO - NOTNLM
OT  - epidermal morphogenesis
OT  - epidermis
OT  - mTOR
OT  - mouse models
OT  - skin barrier
COIS- The authors declare no conflict of interests.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/06/19
CRDT- 2022/06/24 01:12
PHST- 2022/05/12 00:00 [received]
PHST- 2022/06/13 00:00 [revised]
PHST- 2022/06/17 00:00 [accepted]
PHST- 2022/06/24 01:12 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/06/19 00:00 [pmc-release]
AID - biology11060931 [pii]
AID - biology-11-00931 [pii]
AID - 10.3390/biology11060931 [doi]
PST - epublish
SO  - Biology (Basel). 2022 Jun 19;11(6):931. doi: 10.3390/biology11060931.