PMID- 35741592
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 12
IP  - 6
DP  - 2022 May 30
TI  - Olfactory Ensheathing Cells Alleviate Facial Pain in Rats with Trigeminal 
      Neuralgia by Inhibiting the Expression of P2X7 Receptor.
LID - 10.3390/brainsci12060706 [doi]
LID - 706
AB  - Trigeminal neuralgia (TN) is a common facial neuropathic pain that is mainly 
      characterized by spontaneous or induced needling or electric shock pain in the 
      innervation area of the trigeminal nerve. It is also referred to as "the cancer 
      that never dies". The olfactory ensheathing cell (OEC) is a special glial cell in 
      the nervous system that has a strong supportive function in nerve regeneration. 
      Cell transplantation therapy is a useful treatment modality that we believe can 
      be applied in TN management. In this study, OECs were transplanted into the 
      ligation site of the infraorbital nerve of rats. We found that after the OEC 
      transplantation, mechanical pain threshold in the face of the rats was 
      significantly increased. Western blotting, immunofluorescence assay, and reverse 
      transcription-quantitative polymerase chain reaction were performed on the 
      trigeminal ganglia (TG) of model rats. The results revealed a decrease in the 
      expression of P2X7 receptor (P2X7R) in the trigeminal ganglia. Our findings show 
      that OEC transplantation has a good therapeutic effect on TN in rats, and that 
      can reduce the expression of P2X7R in trigeminal ganglia. Therefore, we think 
      that OEC transplantation may be a suitable treatment for TN.
FAU - Lu, Jiafeng
AU  - Lu J
AD  - Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 
      330006, China.
FAU - Yang, Baolin
AU  - Yang B
AD  - Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 
      330006, China.
FAU - Liao, Jiayi
AU  - Liao J
AD  - The Stomatology Medical College of Nanchang University, Nanchang 330006, China.
FAU - Chen, Baokang
AU  - Chen B
AD  - The First Medical College of Nanchang University, Nanchang 330006, China.
FAU - Lu, Mingxin
AU  - Lu M
AD  - The Queen Mary College of Nanchang University, Nanchang 330006, China.
FAU - Zhang, Wenjun
AU  - Zhang W
AD  - Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
FAU - Zeng, Jingnan
AU  - Zeng J
AD  - Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 
      330006, China.
FAU - Cheng, Hui
AU  - Cheng H
AD  - Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 
      330006, China.
FAU - Liu, Zengxu
AU  - Liu Z
AD  - Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 
      330006, China.
LA  - eng
GR  - 82060240, 81760418, 81260190/the National Natural Science Foundation of China/
GR  - 20132019/the Science and Technology Plan of Health Commission of Jiangxi 
      Province/
GR  - GJJ150215/and the Science and Technology Research Project of Education Department 
      of Jiangxi Province/
PT  - Journal Article
DEP - 20220530
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC9220883
OTO - NOTNLM
OT  - Sprague-Dawley
OT  - cell transplantation
OT  - chronic constrictive injury
OT  - glial cell
OT  - immunofluorescence
OT  - infraorbital nerve
OT  - neuropathic pain
OT  - polymerase chain reaction
OT  - trigeminal ganglia
OT  - trigeminal nerve
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/05/30
CRDT- 2022/06/24 01:12
PHST- 2022/04/19 00:00 [received]
PHST- 2022/05/16 00:00 [revised]
PHST- 2022/05/28 00:00 [accepted]
PHST- 2022/06/24 01:12 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/05/30 00:00 [pmc-release]
AID - brainsci12060706 [pii]
AID - brainsci-12-00706 [pii]
AID - 10.3390/brainsci12060706 [doi]
PST - epublish
SO  - Brain Sci. 2022 May 30;12(6):706. doi: 10.3390/brainsci12060706.