PMID- 35742820
OWN - NLM
STAT- MEDLINE
DCOM- 20220627
LR  - 20220716
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 12
DP  - 2022 Jun 7
TI  - How to Restore Oxidative Balance That Was Disrupted by SARS-CoV-2 Infection.
LID - 10.3390/ijms23126377 [doi]
LID - 6377
AB  - Coronavirus 2019 disease (COVID-19) is caused by different variants of severe 
      acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in December 
      of 2019. COVID-19 pathogenesis is complex and involves a dysregulated renin 
      angiotensin system. Severe courses of the disease are associated with a 
      dysregulated immunological response known as cytokine storm. Many scientists have 
      demonstrated that SARS-CoV-2 impacts oxidative homeostasis and stimulates the 
      production of reactive oxygen species (ROS). In addition, the virus inhibits 
      glutathione (GSH) and nuclear factor erythroid 2-related factor 2 (NRF2)-a major 
      antioxidant which induces expression of protective proteins and prevents ROS 
      damage. Furthermore, the virus stimulates NOD-, LRR- and pyrin domain-containing 
      protein 3 (NLRP3) inflammasomes which play a significant role in inducing a 
      cytokine storm. A variety of agents with antioxidant properties have shown 
      beneficial effects in experimental and clinical studies of COVID-19. This review 
      aims to present mechanisms of oxidative stress induced by SARS-CoV-2 and to 
      discuss whether antioxidative drugs can counteract detrimental outcomes of a 
      cytokine storm.
FAU - Kielbowski, Kajetan
AU  - Kielbowski K
AUID- ORCID: 0000-0001-8227-6753
AD  - Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 
      Szczecin, Poland.
FAU - Herian, Mariola
AU  - Herian M
AD  - Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 
      Szczecin, Poland.
FAU - Pawlik, Andrzej
AU  - Pawlik A
AUID- ORCID: 0000-0001-6557-1208
AD  - Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 
      Szczecin, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220607
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Antioxidants/metabolism/therapeutic use
MH  - *COVID-19
MH  - Cytokine Release Syndrome/drug therapy/etiology
MH  - Humans
MH  - Oxidative Stress
MH  - Reactive Oxygen Species
MH  - SARS-CoV-2
PMC - PMC9223498
OTO - NOTNLM
OT  - COVID-19
OT  - SARS-CoV-2
OT  - antioxidants
OT  - cytokine storm
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/28 06:00
PMCR- 2022/06/07
CRDT- 2022/06/24 01:20
PHST- 2022/05/22 00:00 [received]
PHST- 2022/06/04 00:00 [revised]
PHST- 2022/06/05 00:00 [accepted]
PHST- 2022/06/24 01:20 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/28 06:00 [medline]
PHST- 2022/06/07 00:00 [pmc-release]
AID - ijms23126377 [pii]
AID - ijms-23-06377 [pii]
AID - 10.3390/ijms23126377 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jun 7;23(12):6377. doi: 10.3390/ijms23126377.