PMID- 35743358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 12
DP  - 2022 Jun 8
TI  - When Sugar Reaches the Liver: Phenotypes of Patients with Diabetes and NAFLD.
LID - 10.3390/jcm11123286 [doi]
LID - 3286
AB  - Type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) 
      have been traditionally linked to one another. Recent studies suggest that NAFLD 
      may be increasingly common in other types of diabetes such as type 1 diabetes 
      (T1DM) and less frequently ketone-prone and Maturity-onset Diabetes of the Young 
      (MODY) diabetes. In this review, we address the relationship between 
      hyperglycemia and insulin resistance and the onset and progression of NAFLD. In 
      addition, despite the high rate of patients with T2DM and other diabetes 
      phenotypes that can alter liver metabolism and consequently develop steatosis, 
      fibrosis, and cirrhosis, NALFD screening is not still implemented in the daily 
      care routine. Incorporating a clinical algorithm created around a simple, 
      non-invasive, cost-effective model would identify high-risk patients. The 
      principle behind managing these patients is to improve insulin resistance and 
      hyperglycemia states with lifestyle changes, weight loss, and new drug therapies.
FAU - Rojano-Toimil, Alba
AU  - Rojano-Toimil A
AUID- ORCID: 0000-0002-2446-1827
AD  - Endocrinology Department, Vall d'Hebron University Hospital, 08035 Barcelona, 
      Spain.
AD  - Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
FAU - Rivera-Esteban, Jesus
AU  - Rivera-Esteban J
AUID- ORCID: 0000-0003-4357-8817
AD  - Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
AD  - Medicine Department Bellaterra, Universitat Autonoma de Barcelona, 08193 
      Barcelona, Spain.
AD  - Liver Unit, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
FAU - Manzano-Nunez, Ramiro
AU  - Manzano-Nunez R
AUID- ORCID: 0000-0001-7444-9634
AD  - Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
AD  - Liver Unit, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
FAU - Banares, Juan
AU  - Banares J
AD  - Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
AD  - Liver Unit, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
FAU - Martinez Selva, David
AU  - Martinez Selva D
AD  - Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
AD  - Spanish Network of Biomedical Research Centers, Diabetes and Metabolic Associated 
      Disorders (CIBERdem), 28029 Madrid, Spain.
FAU - Gabriel-Medina, Pablo
AU  - Gabriel-Medina P
AD  - Biochemistry Department, Vall d'Hebron University Hospital, 08035 Barcelona, 
      Spain.
AD  - Biochemistry and Molecular Biology Department, Universitat Autonoma de Barcelona 
      (UAB), Bellaterra, 08193 Barcelona, Spain.
FAU - Ferrer, Roser
AU  - Ferrer R
AUID- ORCID: 0000-0002-8925-3172
AD  - Biochemistry Department, Vall d'Hebron University Hospital, 08035 Barcelona, 
      Spain.
FAU - Pericas, Juan M
AU  - Pericas JM
AUID- ORCID: 0000-0002-3645-3293
AD  - Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
AD  - Liver Unit, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
AD  - Spanish Network of Biomedical Research Centers, Liver and Digestive Diseases 
      (CIBERehd), 28801 Madrid, Spain.
FAU - Ciudin, Andreea
AU  - Ciudin A
AUID- ORCID: 0000-0001-5622-0203
AD  - Endocrinology Department, Vall d'Hebron University Hospital, 08035 Barcelona, 
      Spain.
AD  - Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
AD  - Medicine Department Bellaterra, Universitat Autonoma de Barcelona, 08193 
      Barcelona, Spain.
AD  - Spanish Network of Biomedical Research Centers, Diabetes and Metabolic Associated 
      Disorders (CIBERdem), 28029 Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220608
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9225139
OTO - NOTNLM
OT  - MODY diabetes
OT  - NAFLD
OT  - NASH
OT  - ketone-prone diabetes
OT  - liver fibrosis
OT  - type 1 diabetes
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/06/08
CRDT- 2022/06/24 01:24
PHST- 2022/04/29 00:00 [received]
PHST- 2022/06/03 00:00 [revised]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/06/24 01:24 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/06/08 00:00 [pmc-release]
AID - jcm11123286 [pii]
AID - jcm-11-03286 [pii]
AID - 10.3390/jcm11123286 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jun 8;11(12):3286. doi: 10.3390/jcm11123286.