PMID- 35743361
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 12
DP  - 2022 Jun 8
TI  - Biomarkers in Primary Focal Segmental Glomerulosclerosis in Optimal 
      Diagnostic-Therapeutic Strategy.
LID - 10.3390/jcm11123292 [doi]
LID - 3292
AB  - Focal segmental glomerulosclerosis (FSGS) involves podocyte injury. In patients 
      with nephrotic syndrome, progression to end-stage renal disease often occurs over 
      the course of 5 to 10 years. The diagnosis is based on a renal biopsy. It is 
      presumed that primary FSGS is caused by an unknown plasma factor that might be 
      responsible for the recurrence of FSGS after kidney transplantation. The nature 
      of circulating permeability factors is not explained and particular biological 
      molecules responsible for inducing FSGS are still unknown. Several substances 
      have been proposed as potential circulating factors such as soluble 
      urokinase-type plasminogen activator receptor (suPAR) and 
      cardiolipin-like-cytokine 1 (CLC-1). Many studies have also attempted to 
      establish which molecules are related to podocyte injury in the pathogenesis of 
      FSGS such as plasminogen activator inhibitor type-1 (PAI-1), angiotensin II type 
      1 receptors (AT1R), dystroglycan(DG), microRNAs, metalloproteinases (MMPs), 
      forkheadbox P3 (FOXP3), and poly-ADP-ribose polymerase-1 (PARP1). Some biomarkers 
      have also been studied in the context of kidney tissue damage progression: 
      transforming growth factor-beta (TGF-beta), human neutrophil gelatinase-associated 
      lipocalin (NGAL), malondialdehyde (MDA), and others. This paper describes 
      molecules that could potentially be considered as circulating factors causing 
      primary FSGS.
FAU - Musiala, Aleksandra
AU  - Musiala A
AUID- ORCID: 0000-0001-7358-2046
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, 50-556 Wroclaw, Poland.
FAU - Donizy, Piotr
AU  - Donizy P
AD  - Department of Clinical and Experimental Pathology, Division of Clinical 
      Pathology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
FAU - Augustyniak-Bartosik, Hanna
AU  - Augustyniak-Bartosik H
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, 50-556 Wroclaw, Poland.
FAU - Jakuszko, Katarzyna
AU  - Jakuszko K
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, 50-556 Wroclaw, Poland.
FAU - Banasik, Miroslaw
AU  - Banasik M
AUID- ORCID: 0000-0002-0588-1551
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, 50-556 Wroclaw, Poland.
FAU - Koscielska-Kasprzak, Katarzyna
AU  - Koscielska-Kasprzak K
AUID- ORCID: 0000-0002-3216-438X
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, 50-556 Wroclaw, Poland.
FAU - Krajewska, Magdalena
AU  - Krajewska M
AUID- ORCID: 0000-0002-2632-2409
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, 50-556 Wroclaw, Poland.
FAU - Kaminska, Dorota
AU  - Kaminska D
AUID- ORCID: 0000-0003-2400-9328
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, 50-556 Wroclaw, Poland.
LA  - eng
GR  - STM.C 160.20.069/Grant information: Wroclaw Medical University/
PT  - Journal Article
PT  - Review
DEP - 20220608
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9225193
OTO - NOTNLM
OT  - biomarkers
OT  - glomerulonephritis
OT  - primary FSGS
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/06/08
CRDT- 2022/06/24 01:24
PHST- 2022/04/18 00:00 [received]
PHST- 2022/06/02 00:00 [revised]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/06/24 01:24 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/06/08 00:00 [pmc-release]
AID - jcm11123292 [pii]
AID - jcm-11-03292 [pii]
AID - 10.3390/jcm11123292 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jun 8;11(12):3292. doi: 10.3390/jcm11123292.