PMID- 35743374
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 12
DP  - 2022 Jun 9
TI  - The Incidence of Chronic Limb-Threatening Ischemia in the Midland Region of New 
      Zealand over a 12-Year Period.
LID - 10.3390/jcm11123303 [doi]
LID - 3303
AB  - The epidemiology of severe PAD, as characterized by short-distance intermittent 
      claudication (IC) and chronic limb-threatening ischemia (CLTI), remains undefined 
      in New Zealand (NZ). This was a retrospective observational cohort study of the 
      Midland region in NZ, including all lower limb PAD-related surgical and 
      percutaneous interventions between the 1st of January 2010 and the 31st of 
      December 2021. Overall, 2541 patients were included. The mean annual incidence of 
      short-distance IC was 15.8 per 100,000, and of CLTI was 36.2 per 100,000 
      population. The annual incidence of both conditions was greater in men. Women 
      presented 3 years older with PAD (p < 0.001). Patients with short-distance IC had 
      lower ipsilateral major limb amputation at 30 days compared to CLTI (IC 2, 0.3% 
      vs. CLTI 298, 16.7%, p < 0.001). The 30-day mortality was greater in elderly 
      patients (<65 years 2.7% vs. >/=65 years 4.4%, p = 0.049), but did not differ 
      depending on sex (females 36, 3.7% vs. males 64, 4.1%, p = 0.787). Elderly age 
      was associated with a worse survival for both short-distance IC and CLTI. There 
      was a worse survival for females with CLTI. In conclusion, PAD imposes a 
      significant burden in NZ, and further research is required in order to reduce 
      this disparity.
FAU - Hart, Odette
AU  - Hart O
AUID- ORCID: 0000-0002-6330-2810
AD  - Faculty of Medical and Health Sciences, The University of Auckland, Auckland 
      1010, New Zealand.
AD  - Department of Vascular and Endovascular Surgery, Waikato District Health Board, 
      Hamilton 3204, New Zealand.
FAU - Xue, Nicole
AU  - Xue N
AD  - Faculty of Medical and Health Sciences, The University of Auckland, Auckland 
      1010, New Zealand.
FAU - Davis-Havill, Brittany
AU  - Davis-Havill B
AD  - Faculty of Medical and Health Sciences, The University of Auckland, Auckland 
      1010, New Zealand.
FAU - Pottier, Mark
AU  - Pottier M
AD  - Faculty of Medical and Health Sciences, The University of Auckland, Auckland 
      1010, New Zealand.
FAU - Prakash, Minesh
AU  - Prakash M
AD  - Department of Vascular and Endovascular Surgery, Waikato District Health Board, 
      Hamilton 3204, New Zealand.
FAU - Reimann, Sascha-Akito
AU  - Reimann SA
AD  - Department of Vascular and Endovascular Surgery, Waikato District Health Board, 
      Hamilton 3204, New Zealand.
FAU - King, Jasmin
AU  - King J
AD  - Department of Vascular and Endovascular Surgery, Waikato District Health Board, 
      Hamilton 3204, New Zealand.
FAU - Xu, William
AU  - Xu W
AD  - Faculty of Medical and Health Sciences, The University of Auckland, Auckland 
      1010, New Zealand.
FAU - Khashram, Manar
AU  - Khashram M
AUID- ORCID: 0000-0003-4921-8433
AD  - Faculty of Medical and Health Sciences, The University of Auckland, Auckland 
      1010, New Zealand.
AD  - Department of Vascular and Endovascular Surgery, Waikato District Health Board, 
      Hamilton 3204, New Zealand.
LA  - eng
GR  - None/Royal Australasian College of Surgeons/
PT  - Journal Article
DEP - 20220609
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9225294
OTO - NOTNLM
OT  - arteriosclerosis
OT  - chronic limb-threatening ischemia
OT  - epidemiology
OT  - health services research
OT  - incidence
OT  - intermittent claudication
OT  - peripheral artery disease
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/06/09
CRDT- 2022/06/24 01:24
PHST- 2022/05/24 00:00 [received]
PHST- 2022/06/05 00:00 [revised]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/06/24 01:24 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/06/09 00:00 [pmc-release]
AID - jcm11123303 [pii]
AID - jcm-11-03303 [pii]
AID - 10.3390/jcm11123303 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jun 9;11(12):3303. doi: 10.3390/jcm11123303.