PMID- 35743697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 6
DP  - 2022 May 31
TI  - Cardiac Allograft Rejection Induces Changes in Nucleocytoplasmic Transport: 
      RANGAP1 as a Potential Non-Invasive Biomarker.
LID - 10.3390/jpm12060913 [doi]
LID - 913
AB  - The non-invasive diagnosis of acute cellular rejection (ACR) is a major 
      challenge. We performed a molecular study analyzing the predictive capacity of 
      serum RanGTPase AP1 (RANGAP1) for diagnosing ACR during the first year after 
      heart transplantation (HT). We included the serum samples of 75 consecutive HT 
      patients, extracted after clinical stability, to determine the RANGAP1 levels 
      through ELISA. In addition, various clinical, analytical, and echocardiographic 
      variables, as well as endomyocardial biopsy results, were collected. RANGAP1 
      levels were higher in patients who developed ACR (median 63.15 ng/mL; 
      (inter-quartile range (IQR), 36.61-105.69) vs. 35.33 ng/mL (IQR, 19.18-64.59); p 
      = 0.02). Receiver operating characteristic (ROC) curve analysis confirmed that 
      RANGAP1 differentiated between patients with and without ACR (area under curve 
      (AUC), 0.70; p = 0.02), and a RANGAP1 level exceeding the cut-off point (>/=90 
      ng/mL) was identified as a risk factor for the development of ACR (OR, 6.8; p = 
      0.006). Two independent predictors of ACR identified in this study were higher 
      RANGAP1 and N-terminal pro-brain natriuretic peptide levels. The analysis of the 
      ROC curve of the model showed a significant AUC of 0.77, p = 0.001. Our findings 
      suggest that RANGAP1 quantification facilitates risk prediction for the 
      occurrence of ACR and could be considered as a novel non-invasive biomarker of 
      ACR.
FAU - Lozano-Edo, Silvia
AU  - Lozano-Edo S
AUID- ORCID: 0000-0003-2718-9571
AD  - Heart Failure and Transplantation Unit, Cardiology Department, University and 
      Polytechnic La Fe Hospital, 46026 Valencia, Spain.
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
FAU - Rosello-Lleti, Esther
AU  - Rosello-Lleti E
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
AD  - Center for Biomedical Research Network on Cardiovascular Diseases (Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares: CIBERCV), 28029 
      Madrid, Spain.
FAU - Sanchez-Lazaro, Ignacio
AU  - Sanchez-Lazaro I
AD  - Heart Failure and Transplantation Unit, Cardiology Department, University and 
      Polytechnic La Fe Hospital, 46026 Valencia, Spain.
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
AD  - Center for Biomedical Research Network on Cardiovascular Diseases (Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares: CIBERCV), 28029 
      Madrid, Spain.
FAU - Tarazon, Estefania
AU  - Tarazon E
AUID- ORCID: 0000-0003-3466-2558
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
AD  - Center for Biomedical Research Network on Cardiovascular Diseases (Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares: CIBERCV), 28029 
      Madrid, Spain.
FAU - Portoles, Manuel
AU  - Portoles M
AUID- ORCID: 0000-0002-4415-7160
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
AD  - Center for Biomedical Research Network on Cardiovascular Diseases (Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares: CIBERCV), 28029 
      Madrid, Spain.
FAU - Ezzitouny, Maryem
AU  - Ezzitouny M
AD  - Heart Failure and Transplantation Unit, Cardiology Department, University and 
      Polytechnic La Fe Hospital, 46026 Valencia, Spain.
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
FAU - Lopez-Vilella, Raquel
AU  - Lopez-Vilella R
AD  - Heart Failure and Transplantation Unit, Cardiology Department, University and 
      Polytechnic La Fe Hospital, 46026 Valencia, Spain.
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
FAU - Arnau, Miguel Angel
AU  - Arnau MA
AD  - Heart Failure and Transplantation Unit, Cardiology Department, University and 
      Polytechnic La Fe Hospital, 46026 Valencia, Spain.
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
FAU - Almenar, Luis
AU  - Almenar L
AD  - Heart Failure and Transplantation Unit, Cardiology Department, University and 
      Polytechnic La Fe Hospital, 46026 Valencia, Spain.
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
AD  - Center for Biomedical Research Network on Cardiovascular Diseases (Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares: CIBERCV), 28029 
      Madrid, Spain.
FAU - Martinez-Dolz, Luis
AU  - Martinez-Dolz L
AUID- ORCID: 0000-0001-5145-8191
AD  - Heart Failure and Transplantation Unit, Cardiology Department, University and 
      Polytechnic La Fe Hospital, 46026 Valencia, Spain.
AD  - Clinical and Translational Research Group in Cardiology, Health Research 
      Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
AD  - Center for Biomedical Research Network on Cardiovascular Diseases (Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares: CIBERCV), 28029 
      Madrid, Spain.
LA  - eng
GR  - PI16/01627/Instituto de Salud Carlos III/
GR  - PI20/00071/Instituto de Salud Carlos III/
GR  - PI20/01469/Instituto de Salud Carlos III/
GR  - CP18/00145/Instituto de Salud Carlos III/
GR  - CP21/00041/Instituto de Salud Carlos III/
GR  - CB16/11/00261/Centro de Investigacion en Red en Enfermedades Cardiovasculares/
GR  - European Regional Development Fund/
PT  - Journal Article
DEP - 20220531
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9225640
OTO - NOTNLM
OT  - RANGAP1
OT  - biomarkers
OT  - cardiac rejection
OT  - heart transplantation
OT  - nucleocytoplasmic transport
COIS- The authors declare no conflict of interest.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/05/31
CRDT- 2022/06/24 01:26
PHST- 2022/04/28 00:00 [received]
PHST- 2022/05/26 00:00 [revised]
PHST- 2022/05/29 00:00 [accepted]
PHST- 2022/06/24 01:26 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/05/31 00:00 [pmc-release]
AID - jpm12060913 [pii]
AID - jpm-12-00913 [pii]
AID - 10.3390/jpm12060913 [doi]
PST - epublish
SO  - J Pers Med. 2022 May 31;12(6):913. doi: 10.3390/jpm12060913.