PMID- 35745525
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 11
IP  - 6
DP  - 2022 Jun 10
TI  - Cross-Sectional Study on the Prevalence of PCV Types 2 and 3 DNA in Suckling 
      Piglets Compared to Grow-Finish Pigs in Downstream Production.
LID - 10.3390/pathogens11060671 [doi]
LID - 671
AB  - Vertical transmission is a consistently discussed pathway of porcine circovirus 
      type 2 (PCV2) and porcine circovirus type 3 (PCV3) transmission in pigs. To 
      evaluate the presence of PCV2 and PCV3 in piglets, we collected tissue samples 
      from 185 piglets that were crushed within the first week of life from 16 farms 
      located in Germany and Austria. Pooled samples consisting of thymus, inguinal 
      lymph node, myocardium, lung and spleen were examined for PCV2 and PCV3 by qPCR. 
      Furthermore, oral fluid samples (OFS) from grow-finish pigs were collected and 
      examined the same way. In piglets, PCV2 was highly prevalent (litters: 69.4%; 
      piglets: 61.6%), whereas PCV3 prevalence was low (litters: 13.4%; piglets: 
      13.0%). In total, 72.6% and 67.2% of all collected OFS were PCV2 or PCV3 
      positive, respectively. Sow vaccination against PCV2 was identified as a 
      protective factor concerning PCV2 in piglets (OR: 0.279; CI: 0.134-0.578; p < 
      0.001), whereas the porcine reproductive and respiratory syndrome virus (PRRSV) 
      vaccination of sows was identified as a protective factor concerning PCV3 in 
      piglets (OR: 0.252 CI: 0.104-0.610; p = 0.002). Our results show that PCV2, but 
      not PCV3, is ubiquitous in suckling piglets and that early PCV3 infections might 
      be modulated by PRRSV-PCV3 interaction. However, the ubiquitous nature of both 
      viruses in older pigs could be confirmed.
FAU - Eddicks, Matthias
AU  - Eddicks M
AD  - Clinic for Swine at the Centre for Clinical Veterinary Medicine, 
      Ludwig-Maximilians-Universitat Munchen, 85764 Oberschleissheim, Germany.
FAU - Maurer, Roland
AU  - Maurer R
AD  - Clinic for Swine at the Centre for Clinical Veterinary Medicine, 
      Ludwig-Maximilians-Universitat Munchen, 85764 Oberschleissheim, Germany.
FAU - Deffner, Pauline
AU  - Deffner P
AUID- ORCID: 0000-0002-7226-9135
AD  - Clinic for Swine at the Centre for Clinical Veterinary Medicine, 
      Ludwig-Maximilians-Universitat Munchen, 85764 Oberschleissheim, Germany.
FAU - Eddicks, Lina
AU  - Eddicks L
AD  - Institute of Veterinary Pathology at the Centre for Clinical Veterinary Medicine, 
      Ludwig-Maximilians-Universitat Munchen, 80539 Munich, Germany.
FAU - Sipos, Wolfgang
AU  - Sipos W
AUID- ORCID: 0000-0001-8209-1804
AD  - Clinical Department for Farm Animals and Herd Management, University of 
      Veterinary Medicine Vienna, 1210 Vienna, Austria.
FAU - Reese, Sven
AU  - Reese S
AUID- ORCID: 0000-0002-4605-9791
AD  - Institute for Anatomy, Histology and Embryology, Ludwig-Maximilians-Universitat 
      Munchen, 80539 Munich, Germany.
FAU - Cvjetkovic, Vojislav
AU  - Cvjetkovic V
AD  - Ceva Tiergesundheit GmbH, 40472 Duesseldorf, Germany.
FAU - Krejci, Roman
AU  - Krejci R
AD  - Ceva Sante Animale, 33500 Libourne, France.
FAU - Opriessnig, Tanja
AU  - Opriessnig T
AUID- ORCID: 0000-0001-9642-0904
AD  - The Roslin Institute and The Royal (Dick) School of Veterinary Studies, 
      University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
AD  - Department of Veterinary Diagnostic and Production Animal Medicine, College of 
      Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
FAU - Ritzmann, Mathias
AU  - Ritzmann M
AD  - Clinic for Swine at the Centre for Clinical Veterinary Medicine, 
      Ludwig-Maximilians-Universitat Munchen, 85764 Oberschleissheim, Germany.
FAU - Fux, Robert
AU  - Fux R
AUID- ORCID: 0000-0002-1149-1613
AD  - Division of Virology, Department of Veterinary Sciences, 
      Ludwig-Maximilians-Universitat Munchen, 80539 Munich, Germany.
LA  - eng
GR  - BBS/E/D/20002173 and BBS/E/D/20002174/Biotechnology and Biological Sciences 
      Research Council (BBSRC)/
PT  - Journal Article
DEP - 20220610
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC9227362
OTO - NOTNLM
OT  - oral fluids
OT  - porcine circoviruses
OT  - suckling piglets
OT  - tissue samples
COIS- The authors confirm that they have no conflict of interest. R.K. and V.C. are the 
      employees of Ceva Sante Animale and Ceva Tiergesundheit, respectively. R.K. and 
      V.C. were not involved in the statistical analysis.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/06/10
CRDT- 2022/06/24 01:36
PHST- 2022/05/05 00:00 [received]
PHST- 2022/06/02 00:00 [revised]
PHST- 2022/06/05 00:00 [accepted]
PHST- 2022/06/24 01:36 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/06/10 00:00 [pmc-release]
AID - pathogens11060671 [pii]
AID - pathogens-11-00671 [pii]
AID - 10.3390/pathogens11060671 [doi]
PST - epublish
SO  - Pathogens. 2022 Jun 10;11(6):671. doi: 10.3390/pathogens11060671.