PMID- 35746166
OWN - NLM
STAT- MEDLINE
DCOM- 20220627
LR  - 20220716
IS  - 1424-8220 (Electronic)
IS  - 1424-8220 (Linking)
VI  - 22
IP  - 12
DP  - 2022 Jun 9
TI  - Mechanocardiography in the Detection of Acute ST Elevation Myocardial Infarction: 
      The MECHANO-STEMI Study.
LID - 10.3390/s22124384 [doi]
LID - 4384
AB  - Novel means to minimize treatment delays in patients with ST elevation myocardial 
      infarction (STEMI) are needed. Using an accelerometer and gyroscope on the chest 
      yield mechanocardiographic (MCG) data. We investigated whether STEMI causes 
      changes in MCG signals which could help to detect STEMI. The study group 
      consisted of 41 STEMI patients and 49 control patients referred for elective 
      coronary angiography and having normal left ventricular function and no valvular 
      heart disease or arrhythmia. MCG signals were recorded on the upper sternum in 
      supine position upon arrival to the catheterization laboratory. In this study, we 
      used a dedicated wearable sensor equipped with 3-axis accelerometer, 3-axis 
      gyroscope and 1-lead ECG in order to facilitate the detection of STEMI in a 
      clinically meaningful way. A supervised machine learning approach was used. 
      Stability of beat morphology, signal strength, maximum amplitude and its timing 
      were calculated in six axes from each window with varying band-pass filters in 
      2-90 Hz range. In total, 613 features were investigated. Using logistic 
      regression classifier and leave-one-person-out cross validation we obtained a 
      sensitivity of 73.9%, specificity of 85.7% and AUC of 0.857 (SD = 0.005) using 
      150 best features. As a result, mechanical signals recorded on the upper chest 
      wall with the accelerometers and gyroscopes differ significantly between STEMI 
      patients and stable patients with normal left ventricular function. Future 
      research will show whether MCG can be used for the early screening of STEMI.
FAU - Koivisto, Tero
AU  - Koivisto T
AUID- ORCID: 0000-0003-3792-8999
AD  - Department of Computing, University of Turku, Vesilinnantie 5, 20500 Turku, 
      Finland.
FAU - Lahdenoja, Olli
AU  - Lahdenoja O
AD  - Department of Computing, University of Turku, Vesilinnantie 5, 20500 Turku, 
      Finland.
FAU - Hurnanen, Tero
AU  - Hurnanen T
AD  - Department of Computing, University of Turku, Vesilinnantie 5, 20500 Turku, 
      Finland.
FAU - Vasankari, Tuija
AU  - Vasankari T
AD  - Heart Center, Turku University Hospital, Hameentie 11, 20520 Turku, Finland.
FAU - Jaakkola, Samuli
AU  - Jaakkola S
AUID- ORCID: 0000-0001-5944-6814
AD  - Heart Center, Turku University Hospital, Hameentie 11, 20520 Turku, Finland.
FAU - Kiviniemi, Tuomas
AU  - Kiviniemi T
AUID- ORCID: 0000-0002-0908-3741
AD  - Heart Center, Turku University Hospital, Hameentie 11, 20520 Turku, Finland.
FAU - Airaksinen, K E Juhani
AU  - Airaksinen KEJ
AUID- ORCID: 0000-0002-0193-568X
AD  - Heart Center, Turku University Hospital, Hameentie 11, 20520 Turku, Finland.
LA  - eng
GR  - 1788/31/2019/Business Finland/
PT  - Journal Article
DEP - 20220609
PL  - Switzerland
TA  - Sensors (Basel)
JT  - Sensors (Basel, Switzerland)
JID - 101204366
SB  - IM
MH  - Arrhythmias, Cardiac
MH  - Coronary Angiography
MH  - Electrocardiography
MH  - Humans
MH  - *ST Elevation Myocardial Infarction/diagnosis
MH  - Sensitivity and Specificity
PMC - PMC9228321
OTO - NOTNLM
OT  - ECG
OT  - STEMI
OT  - accelerometer
OT  - acute myocardial infarction
OT  - electrocardiography
OT  - gyroscope
OT  - seismocardiography
OT  - telemonitoring
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/28 06:00
PMCR- 2022/06/09
CRDT- 2022/06/24 01:40
PHST- 2022/05/02 00:00 [received]
PHST- 2022/06/01 00:00 [revised]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/06/24 01:40 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/28 06:00 [medline]
PHST- 2022/06/09 00:00 [pmc-release]
AID - s22124384 [pii]
AID - sensors-22-04384 [pii]
AID - 10.3390/s22124384 [doi]
PST - epublish
SO  - Sensors (Basel). 2022 Jun 9;22(12):4384. doi: 10.3390/s22124384.