PMID- 35746970
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2667-2421 (Electronic)
IS  - 2667-2421 (Linking)
VI  - 12
DP  - 2022 Jun
TI  - Occurrence of mild cognitive impairment with hyperinsulinaemia in Africans with 
      advanced type 2 diabetes mellitus.
PG  - 182-187
LID - 10.1016/j.ibneur.2022.02.003 [doi]
AB  - There is paucity of information on the prevalence of mild cognitive impairment 
      (MCI) among individuals with type 2 diabetes mellitus (T2DM) in sub-Saharan 
      Africa, including Nigeria. In addition, the role of hyperinsulinaemia in the 
      development of MCI needs further investigation. This study sought to assess 
      cognition and hyperinsulinaemia, with the associated characteristics in patients 
      with advanced T2DM. Cognition was assessed using Montreal cognitive assessment 
      test (MoCA), while fasting plasma insulin was measured using an ELISA kit. Sixty 
      one diabetic subjects and 32 non-diabetic controls, matched for age, gender and 
      level of education were studied. The diabetics had MCI while the controls had 
      normal cognitive function. About 88.5% of the diabetic subjects had MCI, in 
      contrast with only 50% of the non-diabetic controls. The most significantly 
      affected cognitive domains among the diabetics were executive function, naming, 
      attention, abstraction and delayed recall. Among the diabetics, MCI correlated 
      with age, weight and body mass index (BMI); and in addition, age and weight found 
      to be significant predictors of MCI. Plasma insulin concentration among the 
      diabetics (16.24 +/- 13.5 microIU/ml) was more than twice that of the controls 
      (7.59 +/- 2.9 microIU/ml). Hyperinsulinaemia among the diabetics correlated with 
      weight, BMI, blood pressure and fasting blood sugar (FBS). Glycated haemoglobin 
      and FBS levels were higher among diabetics compared with the controls. In 
      conclusion, Africans with advanced T2DM show multi-domain MCI with high 
      prevalence, coexisting with hyperinsulinaemia. Majority of the patients have 
      diabetic complications and poor glycaemic control. Hyperinsulinaemia may play a 
      complementary role in the pathophysiology of MCI in T2DM.
CI  - (c) 2022 The Authors.
FAU - Bashir, J
AU  - Bashir J
AD  - Department of Internal Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
FAU - Yarube, I U
AU  - Yarube IU
AD  - Neuroscience and Pathophysiology Unit, Department of Human Physiology, Bayero 
      University, Kano, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20220217
PL  - Netherlands
TA  - IBRO Neurosci Rep
JT  - IBRO neuroscience reports
JID - 101775148
PMC - PMC9210459
OTO - NOTNLM
OT  - African population
OT  - Cognitive function
OT  - Dementia
OT  - Hyperinsulinaemia
OT  - Insulin
OT  - Mild cognitive impairment (MCI)
OT  - Type 2 diabetes mellitus (T2DM)
COIS- Authors declare no conflict of interests.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/25 06:01
PMCR- 2022/02/17
CRDT- 2022/06/24 02:04
PHST- 2021/01/29 00:00 [received]
PHST- 2022/02/09 00:00 [accepted]
PHST- 2022/06/24 02:04 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/25 06:01 [medline]
PHST- 2022/02/17 00:00 [pmc-release]
AID - S2667-2421(22)00010-0 [pii]
AID - 10.1016/j.ibneur.2022.02.003 [doi]
PST - epublish
SO  - IBRO Neurosci Rep. 2022 Feb 17;12:182-187. doi: 10.1016/j.ibneur.2022.02.003. 
      eCollection 2022 Jun.