PMID- 35749130
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20231114
IS  - 2191-0308 (Electronic)
IS  - 0048-7554 (Linking)
VI  - 38
IP  - 3
DP  - 2023 Sep 26
TI  - Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in 
      different types of milks in Iran.
PG  - 511-518
LID - 10.1515/reveh-2022-0050 [doi]
AB  - REVIEWS: Despite in recent decades, several studies on the concentration of 
      aflatoxins M1(AFM1) in various milks have been studied, as we know, no systematic 
      review, meta-analysis and carcinogenic risk assessment study was conducted in 
      Iran till now. OBJECTIVES: In this study, a systematic review was conducted to 
      collect, meta-analysis and carcinogenic risk assessment of the quantitative data 
      regarding the prevalence and concentration of AFM1 in several types of milk 
      produced in Iran. CONTENT: In our study, the concentration and prevalence of AFM1 
      in different types of milk (Raw, pasteurized, and UHT) from 113 original articles 
      in Iran using searching the Web of Science, PubMed, Scopus, Science Direct and 
      Google Scholar (in Persian and English) databases from 2002 to august 2021 were 
      collected. The concentration of AFM1 was meta-analyzed using the random effect 
      model (REM) based on type of milk (raw, pasteurized and UHT) subgroups and Monte 
      Carlo simulation (MCS) approach was used to assess safety risks and investigate 
      carcinogenic effects of AFM1 using Crystal-Ball software (Version 11.1.3, Oracle, 
      Inc., USA). SUMMARY AND OUTLOOK: The 113 original article (In English and 
      Persian) were included in this review. Meta-analysis indicated lower and upper of 
      AFM1 in subgroups of raw, pasteurized and UHT milk in Iran was 9, 720, 2.7, 
      230.2, 19.23, and 221.6 ng/kg respectively. The Point estimate for carcinogenic 
      risk of AFM1 showed as result of age increasing, the carcinogenic risk of 
      Aflatoxin M 1 decreases and concentration of Aflatoxin M1 (ng/liter), plays the 
      most effective role in carcinogenic risk of AFM1. CONCLUSION: The presence of 
      AFM1 in milk and its products due to its high toxicity and carcinogenic 
      properties is a public health concern that the results show that the risk of 
      carcinogenesis is higher at younger ages (less than 20 years). As a result, there 
      is a strong association between consumption of raw milk, pasteurized milk and UHT 
      and the risk of cancer in children and adults in Iran.
CI  - (c) 2022 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Mortezazadeh, Fatemeh
AU  - Mortezazadeh F
AD  - Student Research Committee, Faculty of Health, Mazandaran University of Medical 
      Sciences, Sari, Iran.
FAU - Gholami-Borujeni, Fathollah
AU  - Gholami-Borujeni F
AD  - Department of Environmental Health Engineering, Faculty of Health, Mazandaran 
      University of Medical Sciences, Sari, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220624
PL  - Germany
TA  - Rev Environ Health
JT  - Reviews on environmental health
JID - 0425754
RN  - 6795-23-9 (Aflatoxin M1)
RN  - 0 (Carcinogens)
SB  - IM
MH  - Adult
MH  - Child
MH  - Humans
MH  - Animals
MH  - *Milk/chemistry
MH  - Iran
MH  - *Aflatoxin M1/analysis
MH  - Carcinogens/analysis
MH  - Food Contamination/analysis
MH  - Risk Assessment
MH  - Carcinogenesis
OTO - NOTNLM
OT  - Iran
OT  - Monte Carlo simulation (MCS)
OT  - aflatoxin M1 (AFM1)
OT  - meta-analysis
OT  - risk assessment
EDAT- 2022/06/25 06:00
MHDA- 2023/09/04 06:42
CRDT- 2022/06/24 11:33
PHST- 2022/03/10 00:00 [received]
PHST- 2022/05/16 00:00 [accepted]
PHST- 2023/09/04 06:42 [medline]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/24 11:33 [entrez]
AID - reveh-2022-0050 [pii]
AID - 10.1515/reveh-2022-0050 [doi]
PST - epublish
SO  - Rev Environ Health. 2022 Jun 24;38(3):511-518. doi: 10.1515/reveh-2022-0050. 
      Print 2023 Sep 26.