PMID- 35749729
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20220707
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 14
IP  - 26
DP  - 2022 Jul 6
TI  - Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE 
      against Allergic Rhinitis.
PG  - 29639-29649
LID - 10.1021/acsami.2c07092 [doi]
AB  - Allergic rhinitis (AR) is a chronic inflammatory reaction by immunoglobulin E 
      (IgE) mediators after individual contact with allergens. It affects 10-40% of the 
      world's population and reduces the quality of life. Long-term symptoms of 
      rhinitis can cause inflammation to spread and trigger asthma, which can harm 
      human health. Herein, we develop a Smart PeptIde defeNse (SPIN) web technique, 
      which in situ constructs a peptide web, trapping IgE against AR. Two candidate 
      SPINs, SPIN-1 and SPIN-2, are designed with different IgE-binding sequences. The 
      SPIN-1 or SPIN-2 is able to bind to IgE and transform from nanoparticles into 
      entangled nanofibers. In turn, the web of SPIN-1 or SPIN-2 acts as a long-term 
      trap of IgE to prevent the IgE from binding to mast cells. SPIN-1 or SPIN-2 (10 
      mg/kg) is able to treat AR model Balb/c mice with high efficiency and reduced 
      symptoms of rhinitis and inflammatory factors, even better than a first-line 
      clinical drug, cetirizine (10 mg/kg). For example, the amount of IL-4 released in 
      the AR group (185.5 +/- 6.8 pg/mL) is significantly reduced after the treatment 
      with SPIN-1 (70.4 +/- 14.1 pg/mL), SPIN-2 (86.0 +/- 9.3 pg/mL), or cetirizine (112.8 
      +/- 19.3 pg/mL). More importantly, compared with the cetirizine group (1 day), the 
      SPIN-1 or SPIN-2 group shows long-term therapeutic effects (1 week). The SPIN web 
      technique shows the great potential for blocking IgE binding to mast cells in 
      vivo, attenuating AR or other allergic reactions.
FAU - Ding, Meng-Ru
AU  - Ding MR
AD  - Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of 
      Education & Hubei Key Laboratory of Catalysis and Materials Science, 
      South-Central Minzu University, Wuhan 430074, P. R. China.
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Liang, Qi-Lin
AU  - Liang QL
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Xu, Huan-Ge
AU  - Xu HG
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Li, Xiang-Dan
AU  - Li XD
AD  - Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of 
      Education & Hubei Key Laboratory of Catalysis and Materials Science, 
      South-Central Minzu University, Wuhan 430074, P. R. China.
FAU - Zhang, Kuo
AU  - Zhang K
AUID- ORCID: 0000-0003-3687-3172
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Wei, Zi-Jin
AU  - Wei ZJ
AD  - Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of 
      Education & Hubei Key Laboratory of Catalysis and Materials Science, 
      South-Central Minzu University, Wuhan 430074, P. R. China.
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Gao, Yong-Hong
AU  - Gao YH
AUID- ORCID: 0000-0003-2575-7694
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Zhang, Qing-Shi
AU  - Zhang QS
AD  - Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of 
      Education & Hubei Key Laboratory of Catalysis and Materials Science, 
      South-Central Minzu University, Wuhan 430074, P. R. China.
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Huang, Rui
AU  - Huang R
AD  - School of Materials Science and Engineering, University of Science and Technology 
      Beijing, Beijing 100083, P. R. China.
FAU - Yang, Huai
AU  - Yang H
AD  - Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Peking 
      University, Beijing 100871, P. R. China.
FAU - Wang, Lei
AU  - Wang L
AUID- ORCID: 0000-0003-1405-9815
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
FAU - Wang, Hao
AU  - Wang H
AUID- ORCID: 0000-0002-1961-0787
AD  - CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 
      100190, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20220624
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Peptides)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - YO7261ME24 (Cetirizine)
SB  - IM
MH  - Animals
MH  - Cetirizine/therapeutic use
MH  - Immunoglobulin E/therapeutic use
MH  - Mice
MH  - Peptides/therapeutic use
MH  - Quality of Life
MH  - *Rhinitis
MH  - *Rhinitis, Allergic/drug therapy
OTO - NOTNLM
OT  - IgE
OT  - allergic rhinitis
OT  - peptide
OT  - self-assembly
OT  - targeting therapy
EDAT- 2022/06/25 06:00
MHDA- 2022/07/08 06:00
CRDT- 2022/06/24 16:53
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
PHST- 2022/06/24 16:53 [entrez]
AID - 10.1021/acsami.2c07092 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2022 Jul 6;14(26):29639-29649. doi: 
      10.1021/acsami.2c07092. Epub 2022 Jun 24.