PMID- 35750435
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20220716
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 15
IP  - 6
DP  - 2022 Jun 24
TI  - Sjogren's syndrome as a cause of both lymphoid interstitial pneumonia and light 
      chain deposition disease in a single patient.
LID - 10.1136/bcr-2022-249747 [doi]
LID - e249747
AB  - A man in his 70s presents with 12 months of progressive dyspnoea, sicca symptoms 
      and Raynaud's phenomenon. Serological testing and tear duct biopsy confirm 
      Sjogren's syndrome (SS). Bilateral nodular-cystic appearances highly suggestive 
      of lymphoid interstitial pneumonia (LIP) are noted on high-resolution computed 
      tomography (HRCT), supported by a 40% lymphocytosis on bronchoalveolar 
      lavage.Biopsy of a non-characteristic additional pulmonary nodule diagnoses light 
      chain deposition disease (LCDD). Extrapulmonary organ involvement is excluded. 
      Pulmonary function tests are well-preserved, and the patient is kept under active 
      surveillance without requiring immunomodulatory treatment.LIP and LCDD both have 
      a strong association with SS. Identification of these disease associations is 
      crucial as they may result in multiorgan involvement or progression to 
      haematological malignancy. This is the first case published in the literature and 
      highlights that a pragmatic approach to investigations can avoid unnecessary 
      procedures, and that treatment may be guided by symptomology.
CI  - (c) BMJ Publishing Group Limited 2022. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Steward, Matthew
AU  - Steward M
AUID- ORCID: 0000-0002-1873-4665
AD  - Department of Respiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, 
      Exeter, Devon, UK matt.steward1@nhs.net.
AD  - College of Medicine and Health, University of Exeter Medical School, Exeter, 
      Devon, UK.
FAU - Yu, Johannes H
AU  - Yu JH
AUID- ORCID: 0000-0002-0882-3955
AD  - College of Medicine and Health, University of Exeter Medical School, Exeter, 
      Devon, UK.
FAU - Gibbons, Michael A
AU  - Gibbons MA
AD  - Department of Respiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, 
      Exeter, Devon, UK.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220624
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - Lymphoid Interstitial Pneumonia
SB  - IM
MH  - Humans
MH  - *Lung Diseases, Interstitial/diagnostic imaging/etiology
MH  - Male
MH  - *Multiple Myeloma/complications
MH  - Respiratory Function Tests
MH  - *Sjogren's Syndrome/complications/diagnosis
MH  - Tomography, X-Ray Computed/adverse effects
PMC - PMC9234793
OTO - NOTNLM
OT  - Connective tissue disease
OT  - Interstitial lung disease
OT  - Sjogren's syndrome
COIS- Competing interests: None declared.
EDAT- 2022/06/25 06:00
MHDA- 2022/06/29 06:00
PMCR- 2024/06/23
CRDT- 2022/06/24 21:07
PHST- 2024/06/23 00:00 [pmc-release]
PHST- 2022/06/24 21:07 [entrez]
PHST- 2022/06/25 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
AID - 15/6/e249747 [pii]
AID - bcr-2022-249747 [pii]
AID - 10.1136/bcr-2022-249747 [doi]
PST - epublish
SO  - BMJ Case Rep. 2022 Jun 24;15(6):e249747. doi: 10.1136/bcr-2022-249747.