PMID- 35752958
OWN - NLM
STAT- MEDLINE
DCOM- 20220715
LR  - 20220725
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 26
IP  - 14
DP  - 2022 Jul
TI  - Transcriptome analysis uncovers the autophagy-mediated regulatory patterns of the 
      immune microenvironment in dilated cardiomyopathy.
PG  - 4101-4112
LID - 10.1111/jcmm.17455 [doi]
AB  - The relationship between autophagy and immunity has been well studied. However, 
      little is known about the role of autophagy in the immune microenvironment during 
      the progression of dilated cardiomyopathy (DCM). Therefore, this study aims to 
      uncover the effect of autophagy on the immune microenvironment in the context of 
      DCM. By investigating the autophagy gene expression differences between healthy 
      donors and DCM samples, 23 dysregulated autophagy genes were identified. Using a 
      series of bioinformatics methods, 13 DCM-related autophagy genes were screened 
      and used to construct a risk prediction model, which can well distinguish DCM and 
      healthy samples. Then, the connections between autophagy and immune responses 
      including infiltrated immunocytes, immune reaction gene-sets and human leukocyte 
      antigen (HLA) genes were systematically evaluated. In addition, two 
      autophagy-mediated expression patterns in DCM were determined via the 
      unsupervised consensus clustering analysis, and the immune characteristics of 
      different patterns were revealed. In conclusion, our study revealed the strong 
      effect of autophagy on the DCM immune microenvironment and provided new insights 
      to understand the pathogenesis and treatment of DCM.
CI  - (c) 2022 The Authors. Journal of Cellular and Molecular Medicine published by 
      Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
FAU - Sun, Shuo
AU  - Sun S
AUID- ORCID: 0000-0003-3812-583X
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Lu, Jiangting
AU  - Lu J
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Lai, Chaojie
AU  - Lai C
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Feng, Zhaojin
AU  - Feng Z
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Sheng, Xia
AU  - Sheng X
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Liu, Xianglan
AU  - Liu X
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Huang, Chengchen
AU  - Huang C
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Shen, Zhida
AU  - Shen Z
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Lv, Qingbo
AU  - Lv Q
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Fu, Guosheng
AU  - Fu G
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
FAU - Shang, Min
AU  - Shang M
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, China.
LA  - eng
GR  - 2021C02053/Key Projects of Zhejiang Province/
GR  - 2021C02057/Key Projects of Zhejiang Province/
GR  - 2016YFD0100703/Ministry of Science and Technology of China/
GR  - LQ22H020010/Natural Science Funds of Zhejiang Province/
GR  - LQ22H020010/Ministry of Science and Technology/
GR  - 2016YFD0100703/Ministry of Science and Technology/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220626
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
SB  - IM
MH  - Autophagy/genetics
MH  - *Cardiomyopathy, Dilated/metabolism
MH  - Computational Biology
MH  - Gene Expression Profiling/methods
MH  - Humans
PMC - PMC9279601
OTO - NOTNLM
OT  - autophagy
OT  - dilated cardiomyopathy (DCM)
OT  - immune microenvironment
OT  - immunity
OT  - transcriptome
COIS- The authors declare that they have no competing interests.
EDAT- 2022/06/27 06:00
MHDA- 2022/07/16 06:00
PMCR- 2022/07/01
CRDT- 2022/06/26 04:52
PHST- 2022/04/04 00:00 [revised]
PHST- 2021/12/04 00:00 [received]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/06/27 06:00 [pubmed]
PHST- 2022/07/16 06:00 [medline]
PHST- 2022/06/26 04:52 [entrez]
PHST- 2022/07/01 00:00 [pmc-release]
AID - JCMM17455 [pii]
AID - 10.1111/jcmm.17455 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2022 Jul;26(14):4101-4112. doi: 10.1111/jcmm.17455. Epub 2022 Jun 
      26.