PMID- 35753112
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220719
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1676
DP  - 2022 Aug 2
TI  - A green and rapid analytical method for determination of kitasamycin in animal 
      feedstuffs by ultra-high performance liquid chromatography tandem mass 
      spectrometry.
PG  - 463203
LID - S0021-9673(22)00396-X [pii]
LID - 10.1016/j.chroma.2022.463203 [doi]
AB  - A rapid, simple, highly efficiency analytical method for detecting kitasamycin 
      A1, A4, A5, and A13 in different feedstuffs was successfully developed by 
      combining enhanced matrix removal (EMR) lipid cartridge and ultra-high 
      performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). After 
      extraction with acetonitrile, the sample supernatants were directly passed 
      through the EMR lipid cartridge. Then, the cartridge was rinsed and eluted with 
      acetonitrile and methanol, respectively, followed by UHPLC-MS/MS analysis with 
      positive mode using multiple reaction monitoring. Optimized pretreatment 
      procedure without solvent conversion, multiple nitrogen drying steps and 
      activated cartridge before loading, and no significant interference were found 
      during the analysis of different types of animal feedstuffs. Excellent 
      sensitivity (Limit of quantification, LOQ) of kitasamycin A1, A4, A5, and A13 was 
      1.1-2.0 microg/kg. Satisfactory recoveries of kitasamycin A1, A4, A5, and A13 in 
      different feedstuffs were from 74.0% to 98.8%, with the relative standard 
      deviations (RSDs) below 10.4%, and good linear correlation coefficient (r)>0.9990 
      in the matrix matched standard curve range of 0.02-50.0 microg/L. Results 
      demonstrated that the developed method exhibited excellent linearity, accuracy, 
      precision, sensitivity, and the feasibility of using this method in kitasamycin 
      determination of animal feedstuffs. The method was evaluated using the greenness 
      analysis method through Eco-Scale assessment tool.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Xu, Feng
AU  - Xu F
AD  - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and 
      Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 
      315211, PR China.
FAU - Yu, Jiayong
AU  - Yu J
AD  - Ningbo Academy of Agricultural Sciences, Ningbo, 315040, PR China.
FAU - Zhang, Rongrong
AU  - Zhang R
AD  - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and 
      Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 
      315211, PR China.
FAU - Zhang, Zeming
AU  - Zhang Z
AD  - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and 
      Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 
      315211, PR China.
FAU - Sun, Aili
AU  - Sun A
AD  - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and 
      Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 
      315211, PR China.
FAU - Shi, Xizhi
AU  - Shi X
AD  - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and 
      Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 
      315211, PR China. Electronic address: shixizhi@nbu.edu.cn.
FAU - Wu, Yinliang
AU  - Wu Y
AD  - Ningbo Academy of Agricultural Sciences, Ningbo, 315040, PR China. Electronic 
      address: wupaddyfield@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20220606
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Acetonitriles)
RN  - 0 (Lipids)
RN  - 1392-21-8 (Kitasamycin)
SB  - IM
MH  - Acetonitriles
MH  - Animals
MH  - Chromatography, High Pressure Liquid/methods
MH  - *Kitasamycin
MH  - Lipids
MH  - Solid Phase Extraction
MH  - *Tandem Mass Spectrometry/methods
OTO - NOTNLM
OT  - Feedstuff
OT  - Kitasamycin
OT  - Matrix removal lipid cartridge
OT  - Solid phase extraction
OT  - UHPLC-MS/MS
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/06/27 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/06/26 18:06
PHST- 2022/04/14 00:00 [received]
PHST- 2022/05/28 00:00 [revised]
PHST- 2022/06/05 00:00 [accepted]
PHST- 2022/06/27 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/06/26 18:06 [entrez]
AID - S0021-9673(22)00396-X [pii]
AID - 10.1016/j.chroma.2022.463203 [doi]
PST - ppublish
SO  - J Chromatogr A. 2022 Aug 2;1676:463203. doi: 10.1016/j.chroma.2022.463203. Epub 
      2022 Jun 6.