PMID- 35753273
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220719
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 241
DP  - 2022 Aug
TI  - Global DNA methylation mediates the association between serum perfluorooctane 
      sulfonate and carotid intima-media thickness in young and middle-aged Taiwanese 
      populations.
PG  - 113782
LID - S0147-6513(22)00622-4 [pii]
LID - 10.1016/j.ecoenv.2022.113782 [doi]
AB  - PURPOSE: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of 
      synthetic chemicals used in the manufacture of many everyday products. Previous 
      reports have shown PFAS exposure may contribute to cardiovascular diseases (CVD). 
      Recent studies have also identified a critical role for DNA methylation, a model 
      of epigenetic regulation, in the pathogenesis of CVD. Additionally, PFAS has been 
      shown to affect DNA methylation. Our previous study reported the positive 
      association between serum perfluorooctane sulfonate (PFOS) levels and mean 
      carotid intima-media thickness (CIMT), a biomarker of arteriosclerosis, in a 
      cohort composed of adolescent and young adult Taiwanese. However, the 
      contribution of DNA methylation in the mechanism of PFOS-induced arteriosclerosis 
      has never been explored in previous literature. APPROACH AND RESULTS: In this 
      cross-sectional study, we included 1425 young and middle-aged Taiwanese 
      individuals (12-63 years) to investigate the correlation between serum PFOS 
      levels, 5mdC/dG (a global DNA methylation marker) and the mean CIMT. We showed 
      that the positive association between serum PFOS levels, 5mdC/dG, and mean CIMT. 
      The regression coefficients of mean CIMT with a one-unit increase in ln-PFOS 
      concentration were higher when the levels of 5mdC/dG were above the 50th 
      percentile in the multiple regression analysis. In the structural equation model 
      (SEM), the results showed that serum PFOS levels were directly correlated with 
      mean CIMT and indirectly correlated with CIMT through 5mdC/dG. CONCLUSIONS: Our 
      results showed that PFOS exposure has direct associations on arteriosclerosis and 
      indirect direct associations on arteriosclerosis through DNA methylation. The 
      results suggest that DNA methylation might regulate the relationship between PFOS 
      and arteriosclerosis in the study subjects. Additional works are required to 
      understand the causal inference between PFOS, DNA methylation, and 
      arteriosclerosis.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Lin, Chien-Yu
AU  - Lin CY
AD  - Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, 
      Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City 242, 
      Taiwan; Department of Environmental Engineering and Health, Yuanpei University of 
      Medical Technology, Hsinchu 300, Taiwan.
FAU - Lee, Hui-Ling
AU  - Lee HL
AD  - Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan.
FAU - Chen, Ching-Way
AU  - Chen CW
AD  - Department of Cardiology, National Taiwan University Hospital Yunlin Branch, 
      Taiwan.
FAU - Wang, Chikang
AU  - Wang C
AD  - Department of Environmental Engineering and Health, Yuanpei University of Medical 
      Technology, Hsinchu 300, Taiwan.
FAU - Sung, Fung-Chang
AU  - Sung FC
AD  - Department of Health Services Administration, China Medical University College of 
      Public Health, Taichung 404, Taiwan; Department of Food Nutrition and Health 
      Biotechnology, Asia University, Taichung 413, Taiwan.
FAU - Su, Ta-Chen
AU  - Su TC
AD  - Department of Environmental and Occupational Medicine, National Taiwan University 
      Hospital, Taipei 100, Taiwan; Division of Cardiology, Department of Internal 
      Medicine, National Taiwan University Hospital, Taipei 100, Taiwan; Institute of 
      Environmental and Occupational Health Sciences, College of Public Health, 
      National Taiwan University, Taipei 100, Taiwan. Electronic address: 
      tachensu@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220623
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Fluorocarbons)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adolescent
MH  - *Alkanesulfonic Acids/toxicity
MH  - Biomarkers
MH  - *Cardiovascular Diseases
MH  - Carotid Intima-Media Thickness
MH  - Cross-Sectional Studies
MH  - DNA Methylation
MH  - Epigenesis, Genetic
MH  - *Fluorocarbons/toxicity
MH  - Humans
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - 5mdC/dG
OT  - CIMT (carotid intima-media thickness)
OT  - Global DNA methylation
OT  - PFAS (Perfluoroalkyl and polyfluoroalkyl substances)
OT  - PFOS (perfluorooctane sulfonate)
EDAT- 2022/06/27 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/06/26 18:20
PHST- 2022/04/02 00:00 [received]
PHST- 2022/06/14 00:00 [revised]
PHST- 2022/06/15 00:00 [accepted]
PHST- 2022/06/27 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/06/26 18:20 [entrez]
AID - S0147-6513(22)00622-4 [pii]
AID - 10.1016/j.ecoenv.2022.113782 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2022 Aug;241:113782. doi: 10.1016/j.ecoenv.2022.113782. 
      Epub 2022 Jun 23.