PMID- 3575344
OWN - NLM
STAT- MEDLINE
DCOM- 19870602
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 26
IP  - 2
DP  - 1987 Feb
TI  - Effect of the chronic ingestion of chlorimipramine and desipramine on the hole 
      board response to acute stresses in male rats.
PG  - 207-10
AB  - The effect of the chronic ingestion of chlorimipramine (CI) or desipramine (DS) 
      on the alterations of hole board behavior caused by a model stress (2 IP 
      injections of physiological saline) and by a short restraint stress (5 min) is 
      analyzed in this study. The experimental groups ingested about 3 mg/kg/24 hr CI 
      or DS for 15 days. Then some experimental and control rats were assigned to 
      control of drug effects on baseline activity. The remaining rats were submitted 
      to saline stress (Experiment I) or restraint stress (Experiment II). The baseline 
      scores of hole board locomotion, head dipping, grooming and defecation were not 
      affected by DS treatment but locomotion slightly increased in the CI treated 
      group. Saline stress impaired significantly head dipping and caused excessive 
      grooming in control rats. The CI treatment induced almost full protection against 
      these behavioral effects of saline stress but DS treatment was ineffective. 
      Restraint stress was found to cause a pronounced inhibition of head dipping as 
      well as a great increase of the scores of grooming in the control group. The CI 
      treatment clearly attenuated these effects of restraint but DS treatment was not 
      effective. The results suggest that male rats treated chronically with CI 
      tolerated both acute stresses better than untreated rats, and that a similar 
      treatment with DS did not provide protection against the effect of such stresses 
      on hole board responding. Inasmuch as CI and DS have different relative potency 
      at noradrenergic and serotonergic systems, it is speculated that this might be in 
      part responsible for their differences as stress protectors.
FAU - Rodriguez Echandia, E L
AU  - Rodriguez Echandia EL
FAU - Broitman, S T
AU  - Broitman ST
FAU - Foscolo, M R
AU  - Foscolo MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - NUV44L116D (Clomipramine)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - Animals
MH  - Clomipramine/*pharmacology
MH  - Desipramine/*pharmacology
MH  - Grooming/drug effects
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Rats
MH  - Restraint, Physical
MH  - Stereotyped Behavior/*drug effects
MH  - Stress, Psychological/physiopathology
OID - NASA: 87204389
EDAT- 1987/02/01 00:00
MHDA- 1987/02/01 00:01
CRDT- 1987/02/01 00:00
PHST- 1987/02/01 00:00 [pubmed]
PHST- 1987/02/01 00:01 [medline]
PHST- 1987/02/01 00:00 [entrez]
AID - 0091-3057(87)90106-7 [pii]
AID - 10.1016/0091-3057(87)90106-7 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1987 Feb;26(2):207-10. doi: 
      10.1016/0091-3057(87)90106-7.