PMID- 35754133
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20220628
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 33
IP  - 6
DP  - 2022 Jun
TI  - Effect of early-life exposure to PM(2)(.5) on childhood asthma/wheezing: a birth 
      cohort study.
LID - 10.1111/pai.13822 [doi]
AB  - BACKGROUND: Although studies have investigated the association between early-life 
      exposure to fine particulate matter (PM(2.5) ) and childhood asthma/wheezing, 
      results are inconsistent and the susceptible exposure window remains largely 
      unknown. METHODS: A prospective birth cohort study was conducted to recruit 
      pregnant women during their early pregnancy, and to follow up them and their 
      children up to 3-4 years old. Diagnosis of asthma/wheezing was extracted from 
      children's medical records. A spatiotemporal land-use regression (ST-LUR) model 
      was used to assess maternal exposure to PM(2.5) during pregnancy and their 
      children's exposure after birth. The Cox proportional hazards model and 
      accelerated failure time model (for violation of proportional hazards assumption) 
      were applied to estimate the effects of prenatal and postnatal exposures to 
      PM(2.5) on the risk of childhood asthma/wheezing. RESULTS: A total of 3725 
      children were included, and 392 children (10.52%) were diagnosed with 
      asthma/wheezing. Both prenatal and postnatal exposures to PM(2.5) were positively 
      associated with the risk of asthma/wheezing. Each interquartile range (IQR) 
      increment in PM(2.5) exposure during the entire pregnancy (4.8 mug/m(3) ) and the 
      period from birth to the end of follow-up (1.5 mug/m(3) ) was associated with 
      adjusted hazard ratios (HRs) of 1.44 [95% confidence interval (CI): 1.13, 1.85] 
      and 2.74 (95% CI: 2.59, 2.91), respectively. Subgroup analyses showed greater HRs 
      for PM(2.5) exposures during the pseudoglandular stage (6-16 gestational weeks 
      [GWs]: IQR = 4.8 mug/m(3) , HR = 1.10, 95% CI: 1.02, 1.18) and canalicular stage 
      (16-24 GWs: IQR = 4.8 mug/m(3) , HR = 1.13, 95% CI:1.03, 1.23) than other stages, 
      and also showed significant effects in the first three-year period after birth 
      (IQR = 1.5 mug/m(3) , HR = 2.37, 95% CI: =2.24, 2.51). CONCLUSION: Higher prenatal 
      and postnatal PM(2.5) exposures may increase the risk of childhood 
      asthma/wheezing. The pseudoglandular stage, canalicular stage, and the first 
      three years after birth may be key susceptible to exposure windows.
CI  - (c) 2022 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
FAU - Chen, Guimin
AU  - Chen G
AD  - School of Public Health, Southern Medical University, Guangzhou, China.
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
FAU - Zhou, He
AU  - Zhou H
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - He, Guanhao
AU  - He G
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
FAU - Zhu, Sui
AU  - Zhu S
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
FAU - Sun, Xiaoli
AU  - Sun X
AD  - Gynecology Department, Guangdong Women and Children Hospital, Guangzhou, China.
FAU - Ye, Yufeng
AU  - Ye Y
AD  - Guangzhou Panyu Central Hospital, Guangzhou, China.
FAU - Chen, Hanwei
AU  - Chen H
AD  - Guangzhou Panyu Central Hospital, Guangzhou, China.
FAU - Xiao, Jianpeng
AU  - Xiao J
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
FAU - Hu, Jianxiong
AU  - Hu J
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
FAU - Zeng, Fangfang
AU  - Zeng F
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
FAU - Yang, Pan
AU  - Yang P
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
FAU - Gao, Yanhui
AU  - Gao Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
FAU - He, Zhongrong
AU  - He Z
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
AD  - School of Public Health, Sun Yat-sen University, Guangzhou, China.
FAU - Wang, Jiong
AU  - Wang J
AD  - School of Public Health, Southern Medical University, Guangzhou, China.
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
FAU - Cao, Ganxiang
AU  - Cao G
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - Chen, Yumeng
AU  - Chen Y
AD  - Guangdong Provincial Center for Disease Control and Prevention, Guangdong 
      Provincial Institute of Public Health, Guangzhou, China.
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - Feng, Hao
AU  - Feng H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
FAU - Ma, Wenjun
AU  - Ma W
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
AD  - Disease Control and Prevention Institute of Jinan University, Jinan University, 
      Guangzhou, China.
FAU - Liu, Chaoqun
AU  - Liu C
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
AD  - Disease Control and Prevention Institute of Jinan University, Jinan University, 
      Guangzhou, China.
FAU - Liu, Tao
AU  - Liu T
AUID- ORCID: 0000-0003-1451-5251
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, Guangzhou, China.
AD  - Disease Control and Prevention Institute of Jinan University, Jinan University, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants/adverse effects/analysis
MH  - *Air Pollution
MH  - *Asthma/epidemiology
MH  - Birth Cohort
MH  - Child
MH  - Cohort Studies
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Humans
MH  - Maternal Exposure/adverse effects
MH  - Particulate Matter/adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/diagnosis/epidemiology
MH  - Prospective Studies
MH  - Respiratory Sounds
OTO - NOTNLM
OT  - air pollution
OT  - asthma
OT  - birth cohort
OT  - children
OT  - pregnancy
OT  - wheezing
EDAT- 2022/06/28 06:00
MHDA- 2022/06/29 06:00
CRDT- 2022/06/27 00:52
PHST- 2022/05/17 00:00 [revised]
PHST- 2022/02/06 00:00 [received]
PHST- 2022/05/31 00:00 [accepted]
PHST- 2022/06/27 00:52 [entrez]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
AID - 10.1111/pai.13822 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2022 Jun;33(6). doi: 10.1111/pai.13822.