PMID- 35757136
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - Morning Versus Evening Dosing of Sublingual Immunotherapy in Allergic Asthma: A 
      Prospective Study.
PG  - 892572
LID - 10.3389/fped.2022.892572 [doi]
LID - 892572
AB  - BACKGROUND: Sublingual immunotherapy (SLIT) has been proved to be an effective 
      and safe treatment for allergic asthma (AS) in children. Nonetheless, several 
      issues regarding SLIT remain to be resolved, including the information about 
      optimal administration timing. METHODS: A total of 163 AS children aged 4-13 
      years were enrolled and randomized into the morning dosing (MD) group and the 
      evening dosing (ED) group. Participants received SLIT with Dermatophagoides 
      farinae drops between 7:00 a. m. and 9:00 a.m. (for the MD group) or between 8:00 
      p. m. and 10:00 p.m. (for the ED group). The total asthma symptom score (TASS), 
      total asthma medicine score (TAMS), Asthma Control Questionnaire (ACQ), forced 
      expiratory volume in one second (FEV(1)), FEV(1)/forced volume vital capacity 
      (FVC), fractional exhaled nitric oxide (FeNO) and adverse events (AEs) were 
      assessed at baseline, 0.5 and 1 year during the 1-year SLIT. RESULTS: After 1 
      year, 62 patients in the MD group and 63 patients in the ED group completed the 
      entire study. The clinical efficacy, pulmonary function and FeNO in both groups 
      improved significantly at 0.5 and 1 year (p < 0.001). Compared to the MD group, 
      the ED group showed significant lower ACQ score at 0.5 year (p < 0.001) and lower 
      FeNO at 1 year (p < 0.05). No significant difference between two groups was 
      observed in AE rate (p > 0.05). All AEs occurred in the first month, with no 
      systemic AEs reported. CONCLUSION: 1-year house dust mite (HDM) SLIT is effective 
      and well-tolerated in AS children regardless of administration time. SLIT dosing 
      in the evening might enhance the asthma control level and reduce FeNO level 
      compared with SLIT dosing in the morning.
CI  - Copyright (c) 2022 Liao, Chen, Wang, Quan, Chen and Lin.
FAU - Liao, Feng
AU  - Liao F
AD  - Center for Prevention and Treatment of Pediatric Asthma, Hainan General Hospital, 
      Hainan Affiliated Hospital of Hainan Medical University, Hainan, China.
FAU - Chen, Shi
AU  - Chen S
AD  - Center for Prevention and Treatment of Pediatric Asthma, Hainan General Hospital, 
      Hainan Affiliated Hospital of Hainan Medical University, Hainan, China.
FAU - Wang, Ling
AU  - Wang L
AD  - Center for Prevention and Treatment of Pediatric Asthma, Hainan General Hospital, 
      Hainan Affiliated Hospital of Hainan Medical University, Hainan, China.
FAU - Quan, Ying-Yu
AU  - Quan YY
AD  - Center for Prevention and Treatment of Pediatric Asthma, Hainan General Hospital, 
      Hainan Affiliated Hospital of Hainan Medical University, Hainan, China.
FAU - Chen, Li-Li
AU  - Chen LL
AD  - Center for Prevention and Treatment of Pediatric Asthma, Hainan General Hospital, 
      Hainan Affiliated Hospital of Hainan Medical University, Hainan, China.
FAU - Lin, Guo-Hua
AU  - Lin GH
AD  - Respiratory Department, Geological Hospital of Hainan Province, Hainan, China.
LA  - eng
PT  - Journal Article
DEP - 20220609
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC9218255
OTO - NOTNLM
OT  - allergen-specific immunotherapy
OT  - allergic asthma
OT  - chronotherapy
OT  - house dust mite
OT  - sublingual immunotherapy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/28 06:00
MHDA- 2022/06/28 06:01
PMCR- 2022/06/09
CRDT- 2022/06/27 04:17
PHST- 2022/03/14 00:00 [received]
PHST- 2022/05/17 00:00 [accepted]
PHST- 2022/06/27 04:17 [entrez]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/06/28 06:01 [medline]
PHST- 2022/06/09 00:00 [pmc-release]
AID - 10.3389/fped.2022.892572 [doi]
PST - epublish
SO  - Front Pediatr. 2022 Jun 9;10:892572. doi: 10.3389/fped.2022.892572. eCollection 
      2022.