PMID- 35757244
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Regulatory Effect of Mung Bean Peptide on Prediabetic Mice Induced by High-Fat 
      Diet.
PG  - 913016
LID - 10.3389/fnut.2022.913016 [doi]
LID - 913016
AB  - Dietary supplementation with mung bean peptides (MBPs) has several health 
      benefits. However, the effect of MBPs on prediabetes and gut microbiota imbalance 
      caused by a high-fat diet (HFD) has not been thoroughly studied. In this study, 
      dietary supplementation with MBPs for 5 weeks significantly reduced HFD-induced 
      body weight gain, hyperglycaemia, hyperlipidaemia, insulin resistance, 
      inflammation, and oxidative stress and alleviated liver and kidney damage in 
      mice. In addition, it significantly reversed the HFD-induced gut microbiota 
      imbalance, increased the gut microbial diversity, and decreased the abundance of 
      Firmicutes and Bacteroidetes in prediabetic mice. Furthermore, we identified 
      Lachnospiraceae_NK4A136 and Lactobacillus as important eubacteria with the 
      potential to alleviate the clinical symptoms of prediabetes. According to 
      PICRUSt2 analysis, the changes in intestinal microflora induced by MBPs diet 
      intervention may be related to the downregulation of expression of genes such as 
      rocR, lysX1, and grdA and regulation of seven pathways, including pyruvate, 
      succinic acid, and butyric acid. Moreover, 17 genera with significantly altered 
      levels in the intestine of HFD-fed mice, including Akkermansia, Roseburia, and 
      Ruminiclostridium, were significantly correlated with 26 important differential 
      metabolites, such as D-glutathione, anti-oleic acid, and cucurbitacin. Overall, 
      these results show that MBPs diet intervention plays a key role in the management 
      of HFD-induced prediabetes.
CI  - Copyright (c) 2022 Li, Tian, Zhang, Feng, Wang, Cheng, Ma, Zhang and Wang.
FAU - Li, Lina
AU  - Li L
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
AD  - Library, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Tian, Yu
AU  - Tian Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Zhang, Shu
AU  - Zhang S
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Feng, Yuchao
AU  - Feng Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Wang, Haoyu
AU  - Wang H
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Cheng, Xiaoyu
AU  - Cheng X
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Ma, Yantao
AU  - Ma Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Library, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Wang, Changyuan
AU  - Wang C
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
LA  - eng
PT  - Journal Article
DEP - 20220609
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9218720
OTO - NOTNLM
OT  - gut microbiota
OT  - hypoglycaemic
OT  - inflammatory reaction
OT  - mung bean peptides (MBPs)
OT  - oxidative stress
OT  - prediabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/28 06:00
MHDA- 2022/06/28 06:01
PMCR- 2022/01/01
CRDT- 2022/06/27 04:20
PHST- 2022/04/05 00:00 [received]
PHST- 2022/04/28 00:00 [accepted]
PHST- 2022/06/27 04:20 [entrez]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/06/28 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.913016 [doi]
PST - epublish
SO  - Front Nutr. 2022 Jun 9;9:913016. doi: 10.3389/fnut.2022.913016. eCollection 2022.