PMID- 35757258
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Extraction, Purification, Physicochemical Properties, and Activity of a New 
      Polysaccharide From Cordyceps cicadae.
PG  - 911310
LID - 10.3389/fnut.2022.911310 [doi]
LID - 911310
AB  - The polysaccharides from C. cicadae were extracted by ultrasonically-assisted 
      enzymatic extraction (UAEE). Response surface analysis was used to determine the 
      optimum parameters as follows: addition of enzymes, 0.71%; extraction 
      temperature, 60 degrees C; extraction time, 18 min; liquid-solid ratio, 46:1 (mL/g). The 
      extraction yield of polysaccharide was 3.66 +/- 0.87%. A novel polysaccharide 
      fraction (JCH-a1) from C. cicadae was extracted and then purified by cellulose 
      DEAE-32 and Sephadex G-100 anion exchange chromatography. The analysis results 
      showed that the molar ratio of galactose, glucose, and mannose in JCH-a1 cells 
      (60.7 kDa) was 0.89:1:0.39. JCH-a1 with a triple helix contains more alpha-glycosides 
      and has strong thermal stability. Moreover, JCH-a1 showed strong antioxidant 
      activity and acted as a strong inhibitor of alpha-glucosidase in vitro. In addition, 
      JCH-a1 can prolong the lifespan of C. elegans. The present study might provide a 
      basis for further study of JCH-a1 as an antioxidant and hypoglycemic food or 
      drug.
CI  - Copyright (c) 2022 Tang, Lin, Chen, Feng, Qin, Xiao, Chen, Liu, Chen, Bu, Li, Cai, 
      Yao and Ding.
FAU - Tang, Zizhong
AU  - Tang Z
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Lin, Wenjie
AU  - Lin W
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Chen, Yusheng
AU  - Chen Y
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Feng, Shiling
AU  - Feng S
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Qin, Yihan
AU  - Qin Y
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Xiao, Yirong
AU  - Xiao Y
AD  - Sichuan Agricultural University Hospital, Sichuan Agricultural University, Ya'an, 
      China.
FAU - Chen, Hong
AU  - Chen H
AD  - College of Food Science, Sichuan Agricultural University, Ya'an, China.
FAU - Liu, Yuntao
AU  - Liu Y
AD  - College of Food Science, Sichuan Agricultural University, Ya'an, China.
FAU - Chen, Hui
AU  - Chen H
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Bu, Tongliang
AU  - Bu T
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Li, Qinfeng
AU  - Li Q
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Cai, Yi
AU  - Cai Y
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Yao, Huipeng
AU  - Yao H
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
FAU - Ding, Chunbang
AU  - Ding C
AD  - College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
LA  - eng
PT  - Journal Article
DEP - 20220609
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9218675
OTO - NOTNLM
OT  - Cordyceps cicadae (C. cicadae)
OT  - extraction
OT  - physicochemical properties
OT  - polysaccharide
OT  - purification
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/28 06:00
MHDA- 2022/06/28 06:01
PMCR- 2022/01/01
CRDT- 2022/06/27 04:20
PHST- 2022/04/02 00:00 [received]
PHST- 2022/05/02 00:00 [accepted]
PHST- 2022/06/27 04:20 [entrez]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/06/28 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.911310 [doi]
PST - epublish
SO  - Front Nutr. 2022 Jun 9;9:911310. doi: 10.3389/fnut.2022.911310. eCollection 2022.