PMID- 35757861
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20221015
IS  - 1747-4094 (Electronic)
IS  - 1747-4094 (Linking)
VI  - 15
IP  - 7
DP  - 2022 Jul
TI  - Thrombotic events in children and adolescent patients with SARS-CoV-2 infection: 
      a systematic review with meta-analysis on incidence and management.
PG  - 635-643
LID - 10.1080/17474086.2022.2094758 [doi]
AB  - OBJECTIVES: The present paper aimed to study the available literature on the 
      hypercoagulability state of pediatric patients affected by COVID-19, and the 
      current management of thrombosis in these patients, considering that no 
      guidelines have been published since now in this age group. METHODS: N 244 titles 
      were screened using the selected MESH words, 180 abstracts and 120 full texts 
      were read, 12 articles were included, and four were analyzed by meta-analysis. 
      RESULTS: Over 1128 COVID-19 positive patients, nearly half of them developed 
      inflammatory sequelae, and 7.35% (40 patients over 544 who developed MIS-C) had 
      thrombotic events. Less than 50% of patients with inflammatory disease were under 
      anticoagulant prophylactic treatment, and doses of anticoagulant protocols vary 
      from different centers. Thrombotic events prevented after the start of 
      unfractionated heparin (UFH) therapy, even if 1.06% (4 patients) died. Only two 
      patients presented complications after anticoagulant treatment, with non-fatal 
      bleeding after UFH treatment. No other complications were reported. No difference 
      in the incidence of thrombotic events between patients under prophylactic low 
      molecular weight heparin (LMWH) and those without was found in meta-analysis 
      (p = 0.32). CONCLUSIONS: Little is known on the incidence and management of hyper 
      coagulopathy in pediatric COVID-19 infection. Further studies have to clarify 
      this topic.
FAU - Vitaliti, Giovanna
AU  - Vitaliti G
AD  - Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero Universitaria 
      Policlinico "G.Rodolico - San Marco, San Marco Hospital, Catania, Italy.
FAU - Giacchi, Valentina
AU  - Giacchi V
AD  - Neonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico 
      "G.Rodolico - San Marco, San Marco Hospital, San Marco Hospital, Catania, Italy.
FAU - Sciacca, Monica
AU  - Sciacca M
AD  - Pediatric, Department of Clinical and Experimental Medicine, University of 
      Catania, Catania, Italy.
FAU - Ruggieri, Martino
AU  - Ruggieri M
AD  - Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical 
      and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, 
      University of Catania, Catania, Italy.
FAU - Falsaperla, Raffaele
AU  - Falsaperla R
AD  - Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero Universitaria 
      Policlinico "G.Rodolico - San Marco, San Marco Hospital, Catania, Italy.
AD  - Neonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico 
      "G.Rodolico - San Marco, San Marco Hospital, San Marco Hospital, Catania, Italy.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220725
PL  - England
TA  - Expert Rev Hematol
JT  - Expert review of hematology
JID - 101485942
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
RN  - pediatric multisystem inflammatory disease, COVID-19 related
SB  - IM
MH  - Adolescent
MH  - Anticoagulants
MH  - *COVID-19/complications/epidemiology
MH  - Child
MH  - Heparin
MH  - Heparin, Low-Molecular-Weight
MH  - Humans
MH  - Incidence
MH  - SARS-CoV-2
MH  - Systemic Inflammatory Response Syndrome
MH  - *Thrombosis/epidemiology/etiology/prevention & control
OTO - NOTNLM
OT  - Thrombosis
OT  - adolescent COVID-19
OT  - anticoagulation therapy
OT  - incidence
OT  - management
OT  - pediatric COVID-19
EDAT- 2022/06/28 06:00
MHDA- 2022/07/29 06:00
CRDT- 2022/06/27 04:34
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/06/27 04:34 [entrez]
AID - 10.1080/17474086.2022.2094758 [doi]
PST - ppublish
SO  - Expert Rev Hematol. 2022 Jul;15(7):635-643. doi: 10.1080/17474086.2022.2094758. 
      Epub 2022 Jul 25.