PMID- 35759827
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220816
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 219
DP  - 2022 Sep 20
TI  - A magnetic ionic liquid based vortex-assisted dispersive liquid-liquid 
      microextraction coupled with back-extraction for the enrichment of 
      fluoroquinolone antibiotics.
PG  - 114903
LID - S0731-7085(22)00324-7 [pii]
LID - 10.1016/j.jpba.2022.114903 [doi]
AB  - In the present work, a magnetic ionic liquid (MIL) ([Co(DMBG)(2)][Co(hfaca)(3)]) 
      was designed and synthesized with both the cation and anion respectively 
      containing a paramagnetic component. With the prepared MIL as the extraction 
      solvent, a vortex-assisted dispersive liquid-liquid microextraction (VA-DLLME) 
      method was developed and combined with back-extraction for the enrichment of five 
      fluoroquinolone antibiotics (FQs). The MIL can be easily collected and separated 
      from the aqueous phase under an external magnetic field due to the strong 
      magnetic susceptibility and red color. Some experimental factors affecting the 
      extraction efficiency were investigated, and the optimum extraction efficiency 
      was obtained in a basic solution (pH=9) for the extraction process and with 2% 
      (v/v) formic acid as the back-extraction solvent. Under the optimized extraction 
      and back-extraction conditions, the proposed method was validated and exhibited 
      good linearity with coefficients of determination (R(2)) above 0.9956 in the 
      range of 2.5-800 ng.mL(-1) and 5.0-800 ng.mL(-1), low limits of detection (LODs) 
      within 0.75-1.5 ng.mL(-1) and satisfactory intra-day and inter-day precisions 
      with relative standard deviations (RSDs) respectively less than 10.6% and 8.6%. 
      Finally, the method was applied for the determination of five FQs in four samples 
      of tap water, milk, honey and chicken, and good precision with RSDs of 0.5-9.5% 
      and acceptable recoveries (73.8-114.3%) were obtained.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Qiao, Lizhen
AU  - Qiao L
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116023, China; School of Chemical Engineering, Dalian University of Technology, 
      Panjin 124221, China. Electronic address: qiaolz@dlut.edu.cn.
FAU - Tao, Yuan
AU  - Tao Y
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116023, China; School of Chemical Engineering, Dalian University of Technology, 
      Panjin 124221, China.
FAU - Yao, Wang
AU  - Yao W
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116023, China; School of Chemical Engineering, Dalian University of Technology, 
      Panjin 124221, China.
FAU - Zhao, Jieyu
AU  - Zhao J
AD  - Department of Environmental Engineering, Hebei University of Environmental 
      Engineering, Qinhuangdao 066102, China.
FAU - Yan, Yang
AU  - Yan Y
AD  - State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 
      116023, China; School of Chemical Engineering, Dalian University of Technology, 
      Panjin 124221, China. Electronic address: yanyang@dlut.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220621
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Ionic Liquids)
RN  - 0 (Solvents)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Anti-Bacterial Agents/analysis
MH  - Fluoroquinolones/analysis
MH  - *Ionic Liquids
MH  - Limit of Detection
MH  - *Liquid Phase Microextraction/methods
MH  - Magnetic Phenomena
MH  - Solvents
MH  - Water
OTO - NOTNLM
OT  - Back-extraction
OT  - Fluoroquinolone antibiotics
OT  - Magnetic ionic liquid
OT  - Vortex-assisted dispersive liquid-liquid microextraction
EDAT- 2022/06/28 06:00
MHDA- 2022/08/17 06:00
CRDT- 2022/06/27 18:14
PHST- 2022/03/16 00:00 [received]
PHST- 2022/06/16 00:00 [revised]
PHST- 2022/06/18 00:00 [accepted]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/06/27 18:14 [entrez]
AID - S0731-7085(22)00324-7 [pii]
AID - 10.1016/j.jpba.2022.114903 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2022 Sep 20;219:114903. doi: 10.1016/j.jpba.2022.114903. 
      Epub 2022 Jun 21.