PMID- 35760111
OWN - NLM
STAT- MEDLINE
DCOM- 20220714
LR  - 20220725
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 202
DP  - 2022 Aug
TI  - Palmatine alleviates LPS-induced acute lung injury via interfering the 
      interaction of TAK1 and TAB1.
PG  - 115120
LID - S0006-2952(22)00214-3 [pii]
LID - 10.1016/j.bcp.2022.115120 [doi]
AB  - Acute lung injury (ALI) is a severe clinical disease marked by uncontrolled 
      inflammation response which lacks effective medicines. Accumulative evidence has 
      indicated that macrophages are therapeutic targets for treating ALI because of 
      its critical role in the inflammatory response.Palmatine (PAL), an isoquinoline 
      alkaloid extracted from natural plants, exhibits effective anti-inflammatory, 
      anti-tumor, and anti-oxidation activities. Here we reported that PAL alleviated 
      LPS-induced acute lung injury and attenuated inflammatory cell infiltration 
      especially neutrophils. Moreover, PAL also attenuated the production of TNF-alpha, 
      CXCL-1, CXCL-2 and nitric oxide in bronchoalveolar lavage fluid. In addition, PAL 
      remarkably reduced LPS-induced expression of TNF-alpha, CXCL-1 and CXCL-2 in bone 
      marrow derived macrophages (BMDMs) and alveolar macrophages (AMs). Treatment with 
      PAL inhibited the phosphorylation and interaction of TAK1/TAB1, which in turn 
      attenuated the p38 MAPK and NF-kappaB signal pathways in BMDMs. Our results indicated 
      that PAL ameliorated LPS-induced ALI by inhibiting macrophage activation through 
      inhibiting NF-kappaB and p38 MAPK pathways, suggesting that PAL has anti-inflammation 
      effect on ALI.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Song, Yunduan
AU  - Song Y
AD  - Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University 
      Pudong Medical Center, Shanghai 201399, PR China; Department of Clinical 
      Laboratory, Tongren Hospital, Shanghai Jiao tong University School of Medicine, 
      1111 Xianxia Road, Changning, Shanghai 200336, PR China.
FAU - Xu, Chunyan
AU  - Xu C
AD  - Department of Respiratory and Critical Care Medicine, Shanghai Pudong Hospital, 
      Fudan University Pudong Medical Center, Shanghai 201399, PR China.
FAU - Wu, Jiaoxiang
AU  - Wu J
AD  - Department of Clinical Laboratory, Tongren Hospital, Shanghai Jiao tong 
      University School of Medicine, 1111 Xianxia Road, Changning, Shanghai 200336, PR 
      China; Key Laboratory for Translational Research and Innovative Therapeutics of 
      Gastrointestinal Oncology, Hongqiao International Institute of Medicine, Tongren 
      Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
FAU - Shu, Jie
AU  - Shu J
AD  - Department of Clinical Laboratory, Tongren Hospital, Shanghai Jiao tong 
      University School of Medicine, 1111 Xianxia Road, Changning, Shanghai 200336, PR 
      China.
FAU - Sheng, Huiming
AU  - Sheng H
AD  - Department of Clinical Laboratory, Tongren Hospital, Shanghai Jiao tong 
      University School of Medicine, 1111 Xianxia Road, Changning, Shanghai 200336, PR 
      China. Electronic address: hmsheng@shsmu.edu.cn.
FAU - Shen, Yao
AU  - Shen Y
AD  - Department of Respiratory and Critical Care Medicine, Shanghai Pudong Hospital, 
      Fudan University Pudong Medical Center, Shanghai 201399, PR China. Electronic 
      address: 20594@shpdh.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220624
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Berberine Alkaloids)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (TAB1 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - G50C034217 (palmatine)
SB  - IM
MH  - *Acute Lung Injury/chemically induced/drug therapy/metabolism
MH  - Adaptor Proteins, Signal Transducing/metabolism
MH  - Berberine Alkaloids
MH  - Cytokines/metabolism
MH  - Humans
MH  - *Lipopolysaccharides
MH  - Lung
MH  - MAP Kinase Kinase Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
OTO - NOTNLM
OT  - Acute lung injury
OT  - Lipopolysaccharide
OT  - Macrophage
OT  - Palmatine (PAL)
OT  - TAK1 and TAB1
EDAT- 2022/06/28 06:00
MHDA- 2022/07/15 06:00
CRDT- 2022/06/27 19:23
PHST- 2022/05/31 00:00 [received]
PHST- 2022/06/01 00:00 [accepted]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/07/15 06:00 [medline]
PHST- 2022/06/27 19:23 [entrez]
AID - S0006-2952(22)00214-3 [pii]
AID - 10.1016/j.bcp.2022.115120 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2022 Aug;202:115120. doi: 10.1016/j.bcp.2022.115120. Epub 2022 
      Jun 24.