PMID- 35760164
OWN - NLM
STAT- MEDLINE
DCOM- 20220901
LR  - 20220906
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 217
DP  - 2022 Sep 30
TI  - Control of drug release from cotton fabric by nanofibrous mat.
PG  - 270-281
LID - S0141-8130(22)01352-6 [pii]
LID - 10.1016/j.ijbiomac.2022.06.138 [doi]
AB  - A drug delivery system (DDSs) was developed in the present study based on textile 
      substrates as drug carriers and electrospun nanofibers as a controller of release 
      rate. Three types of drugs consisting of ciprofloxacin (CIP), clotrimazole (CLO), 
      and benzalkonium chloride (BEN) were loaded into the cover glass (CG) and cotton 
      fabrics (CF1 and CF2) separately. Then, the drug-loaded substrates were coated 
      with polycaprolactone (PCL) and polycaprolactone/gelatin (PCL/Gel) nanofibers 
      with various thicknesses. The morphology and hydrophilicity of the electrospun 
      nanofibers and the release profile of drug-loaded samples were investigated. 
      FTIR, XRD, and in vitro biodegradability analysis were analyzed to characterize 
      the drug delivery system. A morphological study of electrospun fibers showed the 
      mean diameter of the PCL and PCL/Gel nanofibers 127 +/- 25 and 178 +/- 38 nm, 
      respectively. The drug delivery assay revealed that various factors affect the 
      rate of drug releases, such as the type of drug, the type of drug carrier, and 
      the thickness of the covered nanofibers. The study highlights the ability of 
      drugs to load substrates with coated nanofibers as controlled drug delivery 
      systems. In conclusion, it is shown that the obtained samples are excellent 
      candidates for future wound dressing applications.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Moazzami Goudarzi, Zahra
AU  - Moazzami Goudarzi Z
AD  - Institute of Fundamental Technological Research, Polish Academy of Sciences, 
      Pawinskiego 5B, Warsaw 02-106, Poland.
FAU - Soleimani, Mahnaz
AU  - Soleimani M
AD  - Department of Textile Engineering, Isfahan University of Technology, Isfahan 
      84156-83111, Iran.
FAU - Ghasemi-Mobarakeh, Laleh
AU  - Ghasemi-Mobarakeh L
AD  - Department of Textile Engineering, Isfahan University of Technology, Isfahan 
      84156-83111, Iran. Electronic address: laleh.ghasemi@cc.iut.ac.ir.
FAU - Sajkiewicz, Pawel
AU  - Sajkiewicz P
AD  - Institute of Fundamental Technological Research, Polish Academy of Sciences, 
      Pawinskiego 5B, Warsaw 02-106, Poland.
FAU - Sharifianjazi, Fariborz
AU  - Sharifianjazi F
AD  - School of Science and Technology, University of Georgia, Tbilisi, Georgia.
FAU - Esmaeilkhanian, Amirhossein
AU  - Esmaeilkhanian A
AD  - Department of Materials and Metallurgical Engineering, Amirkabir University of 
      Technology, Tehran, Iran.
FAU - Khaksar, Samad
AU  - Khaksar S
AD  - School of Science and Technology, University of Georgia, Tbilisi, Georgia.
LA  - eng
PT  - Journal Article
DEP - 20220624
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Polyesters)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Bandages
MH  - Drug Liberation
MH  - Gelatin/chemistry
MH  - *Nanofibers/chemistry
MH  - Polyesters/chemistry
MH  - Textiles
OTO - NOTNLM
OT  - Ciprofloxacin
OT  - Controlled drug release
OT  - Electrospinning
EDAT- 2022/06/28 06:00
MHDA- 2022/09/02 06:00
CRDT- 2022/06/27 19:24
PHST- 2022/02/17 00:00 [received]
PHST- 2022/06/14 00:00 [revised]
PHST- 2022/06/20 00:00 [accepted]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/09/02 06:00 [medline]
PHST- 2022/06/27 19:24 [entrez]
AID - S0141-8130(22)01352-6 [pii]
AID - 10.1016/j.ijbiomac.2022.06.138 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2022 Sep 30;217:270-281. doi: 
      10.1016/j.ijbiomac.2022.06.138. Epub 2022 Jun 24.