PMID- 35761179
OWN - NLM
STAT- MEDLINE
DCOM- 20220629
LR  - 20231102
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jun 27
TI  - Peripheral arterial disease progression and ankle brachial index: a cohort study 
      with newly diagnosed patients with type 2 diabetes.
PG  - 294
LID - 10.1186/s12872-022-02722-6 [doi]
LID - 294
AB  - BACKGROUND: Little is known about the evolution of peripheral arterial disease 
      (PAD) since diagnosis and its association with glycemic and lipid control in 
      patients with Type 2 Diabetes Mellitus (T2DM). OBJECTIVE: Evaluate the actual 
      criteria to start screening PAD with ankle-brachial index (ABI) in T2DM patients 
      and assess its progression and relationship with glycemic and lipid control since 
      diagnosis. METHODS: We performed a 3-year prospective cohort study with two 
      groups: group 1 (978 individuals with T2DM undergoing drug treatment) and group 2 
      [221 newly diagnosed drug-naive (< 3 months) patients with T2DM]. PAD diagnosis 
      was by ABI </= 0.90, regardless any symptoms. RESULTS: As expected, abnormal ABI 
      prevalence was higher in group 1 vs. Group 2 (87% vs. 60%, p < 0.001). However, 
      abnormal ABI prevalence did not differ between patients over and under 50 years 
      in both groups. Our drug-naive group stabilizes ABI (0.9 +/- 0.1 vs 0.9 +/- 0.1, 
      p = NS) and improved glycemic and lipid control during follow-up [glycated 
      hemoglobin (HbA1c) = 8.9 +/- 2.1 vs 8.4 +/- 2.3%, p < 0.05; LDL = 132 +/- 45 vs 
      113 +/- 38 mg/dL, p < 0.01, respectively]. When compared, patients who evolved with 
      normalization or maintained normal ABI levels at the end [Group A, N = 60 (42%)] 
      with those who decreased ABI to abnormal levels (ABI basal 1.0 +/- 0.1 vs final 
      0.85 +/- 0.1, p < 0.001) [Group B, N = 26 (18%)], an improvement in HbA1c (9 +/- 2 vs 
      8 +/- 2%, p < 0.05) and a correlation between the final HbA1c with ABI (r = - 0.3, 
      p = 0.01) was found only in the first. In addition, a correlation was found 
      between albuminuria variation and ABI solely in group A (r = - 0.3; p < 0.05). 
      CONCLUSION: Our study suggests that ABI should be measured at diagnosis in T2DM 
      patients, indicating that current criteria to select patients to screen PAD with 
      ABI must be simplified. An improvement in albuminuria and glycemic and lipid 
      control could be related with ABI normalization in newly diagnosed T2DM 
      drug-naive patients.
CI  - (c) 2022. The Author(s).
FAU - Felicio, Joao Soares
AU  - Felicio JS
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil. felicio.bel@terra.com.br.
FAU - de Melo, Franciane Trindade Cunha
AU  - de Melo FTC
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - Vieira, Giovana Miranda
AU  - Vieira GM
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Aquino, Vitoria Teixeira
AU  - de Aquino VT
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Souza Parente, Fernanda
AU  - de Souza Parente F
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - da Silva, Wanderson Maia
AU  - da Silva WM
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - Said, Nivin Mazen
AU  - Said NM
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - da Silva, Emanuele Rocha
AU  - da Silva ER
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Souza, Ana Carolina Contente Braga
AU  - de Souza ACCB
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Oliveira, Maria Clara Neres Iunes
AU  - de Oliveira MCNI
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Lemos, Gabriela Nascimento
AU  - de Lemos GN
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Souza, Icaro Jose Araujo
AU  - de Souza IJA
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Alcantara, Angelica Leite
AU  - de Alcantara AL
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Moraes, Lorena Vilhena
AU  - de Moraes LV
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - Abrahao Neto, Joao Felicio
AU  - Abrahao Neto JF
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - de Queiroz, Natercia Neves Marques
AU  - de Queiroz NNM
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - Mourao, Neyla Arroyo Lara
AU  - Mourao NAL
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - Piani, Pedro Paulo Freire
AU  - Piani PPF
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - Oliveira Dos Reis, Melissa de Sa
AU  - Oliveira Dos Reis MS
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
FAU - Felicio, Karem Mileo
AU  - Felicio KM
AD  - Endocrinology Division, University Hospital Joao de Barros Barreto, Federal 
      University of Para, Mundurucus Street, 4487, Guama, Belem, Para, 66073-000, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220627
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
SB  - IM
MH  - Albuminuria
MH  - Ankle Brachial Index
MH  - Blood Glucose
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/diagnosis/drug therapy/epidemiology
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Lipids
MH  - *Peripheral Arterial Disease/diagnosis/epidemiology
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC9238109
OTO - NOTNLM
OT  - Ankle-brachial index
OT  - Diabetes mellitus
OT  - Drug-naive
OT  - Peripheral arterial disease
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/06/28 06:00
MHDA- 2022/06/30 06:00
PMCR- 2022/06/27
CRDT- 2022/06/27 23:37
PHST- 2021/12/28 00:00 [received]
PHST- 2022/06/14 00:00 [accepted]
PHST- 2022/06/27 23:37 [entrez]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/06/30 06:00 [medline]
PHST- 2022/06/27 00:00 [pmc-release]
AID - 10.1186/s12872-022-02722-6 [pii]
AID - 2722 [pii]
AID - 10.1186/s12872-022-02722-6 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2022 Jun 27;22(1):294. doi: 10.1186/s12872-022-02722-6.