PMID- 35761235
OWN - NLM
STAT- MEDLINE
DCOM- 20220629
LR  - 20220716
IS  - 1477-3155 (Electronic)
IS  - 1477-3155 (Linking)
VI  - 20
IP  - 1
DP  - 2022 Jun 27
TI  - Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis 
      progression.
PG  - 303
LID - 10.1186/s12951-022-01505-7 [doi]
LID - 303
AB  - Loss of extracellular matrix (ECM) of cartilage due to oxidative stress injury is 
      one of the main characteristics of osteoarthritis (OA). As a bioactive molecule 
      derived from the traditional Chinese Burdock, arctiin exerts robust antioxidant 
      properties to modulate redox balance. However, the potential therapeutic effects 
      of arctiin on OA and the underlying mechanisms involved are still unknown. Based 
      on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis 
      Platform (TCMSP) tool, Burdock-extracted small molecule arctiin was identified as 
      a potential anti-arthritic component. In vitro, treatment using arctiin rescued 
      the interleukin (IL)-1beta-induced activation of proteinases and promoted the 
      cartilage ECM synthesis in human chondrocytes. In vivo, intraperitoneal injection 
      of arctiin ameliorated cartilage erosion and encountered subchondral bone 
      sclerosis in the post-traumatic OA mice. Transcriptome sequencing uncovered that 
      arctiin-enhanced cartilage matrix deposition was associated with restricted 
      oxidative stress. Mechanistically, inhibition of nuclear factor erythroid 
      2-related factor 2 (NRF2) abolished arctiin-mediated anti-oxidative and 
      anti-arthritic functions. To further broaden the application prospects, a gellan 
      gum (GG)-based bioactive gel (GG-CD@ARC) encapsulated with arctiin was made to 
      achieve long-term and sustained drug release. Intra-articular injection of 
      GG-CD@ARC counteracted cartilage degeneration in the severe (12 weeks) OA mice 
      model. These findings indicate that arctiin may be a promising anti-arthritic 
      agent. Furthermore, GG-modified bioactive glue loaded with arctiin provides a 
      unique strategy for treating moderate to severe OA.
CI  - (c) 2022. The Author(s).
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Hou, Mingzhuang
AU  - Hou M
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Pan, Zejun
AU  - Pan Z
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Tian, Xin
AU  - Tian X
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Zhao, Zhijian
AU  - Zhao Z
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Liu, Tao
AU  - Liu T
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Yang, Huilin
AU  - Yang H
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Shi, Qin
AU  - Shi Q
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China.
FAU - Chen, Xi
AU  - Chen X
AD  - Department of Pathology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, 213003, China.
FAU - Zhang, Yijian
AU  - Zhang Y
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. 
      yjzhang2013@stu.suda.edu.cn.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China. yjzhang2013@stu.suda.edu.cn.
FAU - He, Fan
AU  - He F
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. 
      fanhe@suda.edu.cn.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China. fanhe@suda.edu.cn.
FAU - Zhu, Xuesong
AU  - Zhu X
AD  - Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 
      Soochow University, No. 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. 
      zhuxs@suda.edu.cn.
AD  - Orthopaedic Institute, Medical College, Soochow University, No. 178 East Ganjiang 
      Road, Suzhou, 215000, Jiangsu, China. zhuxs@suda.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220627
PL  - England
TA  - J Nanobiotechnology
JT  - Journal of nanobiotechnology
JID - 101152208
RN  - 0 (Antioxidants)
RN  - 0 (Furans)
RN  - 0 (Glucosides)
RN  - TM5RQ949K7 (arctiin)
SB  - IM
MH  - Animals
MH  - *Antioxidants/pharmacology/therapeutic use
MH  - Chondrocytes
MH  - Furans
MH  - Glucosides/pharmacology/therapeutic use
MH  - Mice
MH  - *Osteoarthritis/drug therapy
PMC - PMC9235181
OTO - NOTNLM
OT  - Arctiin
OT  - Extracellular matrix
OT  - Microcarrier
OT  - NRF2
OT  - Osteoarthritis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/06/28 06:00
MHDA- 2022/06/30 06:00
PMCR- 2022/06/27
CRDT- 2022/06/27 23:40
PHST- 2022/03/11 00:00 [received]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/06/27 23:40 [entrez]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/06/30 06:00 [medline]
PHST- 2022/06/27 00:00 [pmc-release]
AID - 10.1186/s12951-022-01505-7 [pii]
AID - 1505 [pii]
AID - 10.1186/s12951-022-01505-7 [doi]
PST - epublish
SO  - J Nanobiotechnology. 2022 Jun 27;20(1):303. doi: 10.1186/s12951-022-01505-7.