PMID- 35761356
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 19
IP  - 1
DP  - 2022 Jun 27
TI  - Comprehensive evaluation of caloric restriction-induced changes in the metabolome 
      profile of mice.
PG  - 41
LID - 10.1186/s12986-022-00674-4 [doi]
LID - 41
AB  - OBJECTS: Caloric restriction (CR) is known to extend lifespan and exert a 
      protective effect on organs, and is thus a low-cost and easily implemented 
      approach to the health maintenance. However, there have been no studies that have 
      systematically evaluated the metabolic changes that occur in the main tissues 
      affected by CR. This study aimed to explore the target tissues metabolomic 
      profile in CR mice. METHODS: Male C57BL/6J mice were randomly allocated to the CR 
      group (n = 7) and control group (n = 7). A non-targeted gas chromatography-mass 
      spectrometry approach and multivariate analysis were used to identify metabolites 
      in the main tissues (serum, heart, liver, kidney, cortex, hippocampus, lung, 
      muscle, and white adipose) in model of CR. RESULTS: We identified 10 metabolites 
      in the heart that showed differential abundance between the 2 groups, along with 
      9 in kidney, 6 in liver, 6 in lung, 6 in white adipose, 4 in hippocampus, 4 in 
      serum, 3 in cortex, and 2 in muscle. The most significantly altered metabolites 
      were amino acids (AAs) (glycine, aspartic acid, L-isoleucine, L-proline, 
      L-aspartic acid, L-serine, L-hydroxyproline, L-alanine, L-valine, L-threonine, 
      L-glutamic acid, and L-phenylalanine) and fatty acids (FAs) (palmitic acid, 
      1-monopalmitin, glycerol monostearate, docosahexaenoic acid, 16-octadecenoic 
      acid, oleic acid, stearic acid, and hexanoic acid). These metabolites were 
      associated with 7 different functional pathways related to the metabolism of AAs, 
      lipids, and energy. CONCLUSION: Our results provide insight into the specific 
      metabolic changes that are induced by CR and can serve as a reference for 
      physiologic studies on how CR improves health and extends lifespan.
CI  - (c) 2022. The Author(s).
FAU - Xie, Dadi
AU  - Xie D
AD  - Department of Endocrinology, Tengzhou Central People's Hospital, Xingtan Road, 
      Tengzhou, 277500, China.
FAU - Huang, Jinxi
AU  - Huang J
AD  - Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Zhang, Qiang
AU  - Zhang Q
AD  - Clinical Laboratory, Tengzhou Central People's Hospital, Tengzhou, 277500, China.
FAU - Zhao, Shiyuan
AU  - Zhao S
AD  - Jining First People's Hospital, Jining Medical University, Jiankang Road, Jining, 
      272000, China.
FAU - Xue, Hongjia
AU  - Xue H
AD  - Faculty of Science and Engineering, University of Nottingham Ningbo China, 
      Ningbo, 315100, China.
FAU - Yu, Qing-Qing
AU  - Yu QQ
AD  - Laboratory of Biochemistry and Biomedical Materials, College of Marine Life 
      Sciences, Ocean University of China, Qingdao, 266003, China.
AD  - Department of Oncology, Jining First People's Hospital, Jining, 272000, China.
FAU - Sun, Zhuohao
AU  - Sun Z
AD  - Department of Endocrinology, Tengzhou Central People's Hospital, Xingtan Road, 
      Tengzhou, 277500, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Endocrinology, Tengzhou Central People's Hospital, Xingtan Road, 
      Tengzhou, 277500, China.
FAU - Yang, Xiumei
AU  - Yang X
AD  - Department of Endocrinology, Tengzhou Central People's Hospital, Xingtan Road, 
      Tengzhou, 277500, China.
FAU - Shao, Minglei
AU  - Shao M
AD  - Department of Endocrinology, Tengzhou Central People's Hospital, Xingtan Road, 
      Tengzhou, 277500, China.
FAU - Pang, Deshui
AU  - Pang D
AD  - Department of Endocrinology, Tengzhou Central People's Hospital, Xingtan Road, 
      Tengzhou, 277500, China. pangdeshui@163.com.
FAU - Jiang, Pei
AU  - Jiang P
AD  - Jining First People's Hospital, Jining Medical University, Jiankang Road, Jining, 
      272000, China. jiangpeicsu@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20220627
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC9235101
OTO - NOTNLM
OT  - Caloric restriction
OT  - Gas chromatography-mass spectrometry (GC-MS)
OT  - Lifespan
OT  - Metabolite
OT  - Multivariate analysis
COIS- The authors declare that they have no competing interests.
EDAT- 2022/06/28 06:00
MHDA- 2022/06/28 06:01
PMCR- 2022/06/27
CRDT- 2022/06/27 23:48
PHST- 2021/10/29 00:00 [received]
PHST- 2022/06/12 00:00 [accepted]
PHST- 2022/06/27 23:48 [entrez]
PHST- 2022/06/28 06:00 [pubmed]
PHST- 2022/06/28 06:01 [medline]
PHST- 2022/06/27 00:00 [pmc-release]
AID - 10.1186/s12986-022-00674-4 [pii]
AID - 674 [pii]
AID - 10.1186/s12986-022-00674-4 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2022 Jun 27;19(1):41. doi: 10.1186/s12986-022-00674-4.