PMID- 35761682
OWN - NLM
STAT- MEDLINE
DCOM- 20220629
LR  - 20220907
IS  - 1873-7145 (Electronic)
IS  - 0963-9969 (Linking)
VI  - 157
DP  - 2022 Jul
TI  - Flavonoids: Food associations, therapeutic mechanisms, metabolism and 
      nanoformulations.
PG  - 111442
LID - S0963-9969(22)00499-9 [pii]
LID - 10.1016/j.foodres.2022.111442 [doi]
AB  - Flavonoids possess an impressive therapeutic potential, thereby imparting them a 
      nutraceutical character. As it becomes increasingly common to consume foods 
      associated with healing properties, it is imperative to understand the 
      associations of different foods with different classes of nutraceutic compounds, 
      and their mechanisms of therapeutic action. At the same time, it is important to 
      address the limitations thereof so that plausible future directions may be drawn. 
      This review summarizes the food associations of flavonoids, and discusses the 
      mechanisms responsible for imparting them their nutraceutic properties, detailing 
      the nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway, 
      inhibition of inflammatory signaling pathways such as toll-like receptor (TLR), 
      nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), 
      cyclooxygenase 2 (COX-2) and lipoxygenase-2 (LOX-2) mediators. Further on, the 
      review explains the mechanism of flavonoids metabolism, reasons for low 
      bioavailability and thereafter recapitulates the role of technological 
      interventions to overcome the limitations, with a particular focus on 
      nanoformulations that utilize the synergy between flavonoids and biocompatible 
      materials used as nanocarriers, as reported in works spanning over a decade. It 
      is the Generally Recognized as Safe (GRAS) classified carriers that will become 
      the basis for developing functional formulations. It is promisingly noteworthy 
      that some flavonoid formulations have been commercialized and mentioned therein. 
      Such commercially viable and safe for consumption technological applications pave 
      way for bringing science to the table, and add value to the innate properties of 
      flavonoids.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Kaushal, Niharika
AU  - Kaushal N
AD  - Functional Foods and Nanotechnology Group, Department of Biotechnology, Punjabi 
      University, Patiala, Punjab 147002, India.
FAU - Singh, Minni
AU  - Singh M
AD  - Functional Foods and Nanotechnology Group, Department of Biotechnology, Punjabi 
      University, Patiala, Punjab 147002, India. Electronic address: 
      minnisingh@pbi.ac.in.
FAU - Singh Sangwan, Rajender
AU  - Singh Sangwan R
AD  - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 
      201002, India. Electronic address: director@acsir.res.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220530
PL  - Canada
TA  - Food Res Int
JT  - Food research international (Ottawa, Ont.)
JID - 9210143
RN  - 0 (Flavonoids)
RN  - 0 (NF-kappa B)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Biological Availability
MH  - Cyclooxygenase 2/metabolism
MH  - *Flavonoids/pharmacology
MH  - *NF-kappa B/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Bioavailability
OT  - Food flavonoids
OT  - Health benefits
OT  - Limitation
OT  - Nanocarriers
OT  - Nanotechnology
OT  - Nutraceuticals
EDAT- 2022/06/29 06:00
MHDA- 2022/06/30 06:00
CRDT- 2022/06/28 01:03
PHST- 2022/02/08 00:00 [received]
PHST- 2022/05/25 00:00 [revised]
PHST- 2022/05/26 00:00 [accepted]
PHST- 2022/06/28 01:03 [entrez]
PHST- 2022/06/29 06:00 [pubmed]
PHST- 2022/06/30 06:00 [medline]
AID - S0963-9969(22)00499-9 [pii]
AID - 10.1016/j.foodres.2022.111442 [doi]
PST - ppublish
SO  - Food Res Int. 2022 Jul;157:111442. doi: 10.1016/j.foodres.2022.111442. Epub 2022 
      May 30.