PMID- 35762312
OWN - NLM
STAT- MEDLINE
DCOM- 20220629
LR  - 20220716
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 50
IP  - 2
DP  - 2022 Aug
TI  - Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging 
      therapies (Review).
LID - 110 [pii]
LID - 10.3892/ijmm.2022.5166 [doi]
AB  - Connexins (Cxs) play key roles in cellular communication. By facilitating 
      metabolite exchange or interfering with distinct signaling pathways, Cxs affect 
      cell homeostasis, proliferation, and differentiation. Variations in the activity 
      and expression of Cxs have been linked to numerous clinical conditions including 
      carcinomas, cardiac disorders, and wound healing. Recent discoveries on the 
      association between Cxs and angiogenesis have sparked interest in Cx‑mediated 
      angiogenesis due to its essential functions in tissue formation, wound repair, 
      tumor growth, and metastasis. It is now widely recognized that understanding the 
      association between Cxs and angiogenesis may aid in the development of new 
      targeted therapies for angiogenic diseases. The aim of the present review was to 
      provide a comprehensive overview of Cxs and Cx‑mediated angiogenesis, with a 
      focus on therapeutic implications.
FAU - Zhou, Zizi
AU  - Zhou Z
AD  - Department of Cardio‑Thoracic Surgery, Shenzhen University General Hospital, 
      Shenzhen, Guangdong 518055, P.R. China.
FAU - Chai, Wenxiang
AU  - Chai W
AD  - Department of Cardio‑Thoracic Surgery, Shenzhen University General Hospital, 
      Shenzhen, Guangdong 518055, P.R. China.
FAU - Liu, Yi
AU  - Liu Y
AD  - Department of Cardio‑Thoracic Surgery, Shenzhen University General Hospital, 
      Shenzhen, Guangdong 518055, P.R. China.
FAU - Zhou, Meng
AU  - Zhou M
AD  - Department of Cardio‑Thoracic Surgery, Shenzhen University General Hospital, 
      Shenzhen, Guangdong 518055, P.R. China.
FAU - Zhang, Xiaoming
AU  - Zhang X
AD  - Department of Cardio‑Thoracic Surgery, Shenzhen University General Hospital, 
      Shenzhen, Guangdong 518055, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220628
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Connexins)
SB  - IM
MH  - Cell Communication
MH  - Cell Differentiation
MH  - *Connexins/genetics/metabolism
MH  - Gap Junctions/metabolism
MH  - Humans
MH  - *Neoplasms/metabolism/therapy
PMC - PMC9256078
OTO - NOTNLM
OT  - angiogenesis
OT  - cancer
OT  - cardiovascular disorders
OT  - connexins
OT  - gap junctions
OT  - intercellular communication
OT  - wound healing
COIS- The authors declare that they have no competing interests.
EDAT- 2022/06/29 06:00
MHDA- 2022/06/30 06:00
PMCR- 2022/06/24
CRDT- 2022/06/28 04:52
PHST- 2022/03/09 00:00 [received]
PHST- 2022/06/08 00:00 [accepted]
PHST- 2022/06/28 04:52 [entrez]
PHST- 2022/06/29 06:00 [pubmed]
PHST- 2022/06/30 06:00 [medline]
PHST- 2022/06/24 00:00 [pmc-release]
AID - 110 [pii]
AID - ijmm-50-2-05166 [pii]
AID - 10.3892/ijmm.2022.5166 [doi]
PST - ppublish
SO  - Int J Mol Med. 2022 Aug;50(2):110. doi: 10.3892/ijmm.2022.5166. Epub 2022 Jun 28.