PMID- 35763092 OWN - NLM STAT- MEDLINE DCOM- 20220916 LR - 20220916 IS - 1432-1084 (Electronic) IS - 0938-7994 (Linking) VI - 32 IP - 10 DP - 2022 Oct TI - Long-term outcomes of transarterial embolization with lipiodol-bleomycin emulsion plus polyvinyl alcohol particles versus the particles alone for large symptomatic focal nodular hyperplasia: a propensity score-matched analysis. PG - 6840-6849 LID - 10.1007/s00330-022-08972-4 [doi] AB - OBJECTIVES: To compare the efficacy of transarterial embolization (TAE) with polyvinyl alcohol (PVA) particles alone and lipiodol-bleomycin emulsion (LBE) plus PVA particles for patients with unresectable large symptomatic focal nodular hyperplasia (FNH). METHODS: We performed a retrospective analysis of patients who underwent TAE either with PVA particles alone (group A, n = 46) or LBE plus PVA particles (group B, n = 35) for large (>/= 7 cm) symptomatic FNH between January 2002 and February 2019. Propensity score matching (PSM) (1:1) was performed to adjust for potential baseline confounders. Technical success, adverse events (AEs), symptom relief, and changes in the lesion size after TAE were evaluated. Statistical analysis included Wilcoxon rank sum test and chi(2) test. RESULTS: After PSM, no significant differences in baseline characteristics were found between the groups (31 in group A and 31 in group B, with a mean age of 31 years). Technical success was achieved in all patients (100%), without major AEs in both groups. Complete resolution of the abdominal symptoms was reported in 77.4% in group A and 100% in group B (p = 0.037) during a mean follow-up period of 72 months; complete resolution (CR) of the FNH rate was significantly higher in group B than in group A (93.6% vs. 67.7%; p = 0.019). CONCLUSION: Compared with the use PVA particles alone, TAE with LBE plus PVA particles in the treatment of patients with large symptomatic FNH had a significantly higher rates of CR of the FNH and complete relief of the symptoms. KEY POINTS: * Transarterial embolization (TAE) with lipiodol-bleomycin emulsion (LBE) plus PVA particles for the large symptomatic FNH yielded better results than with PVA particles alone, in terms of complete resolution of FNH lesions (93.6% vs 67.7%) and complete relief of the abdominal symptoms (100% vs 77.4%) during a mean follow-up period of 72 months (38-170 months). * No major complications were recorded in both groups, and no significant difference in the incidence of postembolization syndrome were observed between the two groups. CI - (c) 2022. The Author(s), under exclusive licence to European Society of Radiology. FAU - Wang, Mao Qiang AU - Wang MQ AUID- ORCID: 0000-0002-0299-5289 AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. wangmq@vip.sina.com. FAU - Duan, Feng AU - Duan F AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Guan, Yang AU - Guan Y AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Yuan, Bing AU - Yuan B AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Wang, Yan AU - Wang Y AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Yan, Jieyu AU - Yan J AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Zhang, Jin Long AU - Zhang JL AD - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People's Republic of China. FAU - Fu, Jin Xin AU - Fu JX AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Yuan, Kai AU - Yuan K AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Sun, Xuedong AU - Sun X AD - Department of Interventional Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Zhang, Heng AU - Zhang H AD - Department of Radiology, The Second Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China. FAU - Ye, Hui Yi AU - Ye HY AD - Department of Diagnostic Radiology, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Cai, Shou Wang AU - Cai SW AD - Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Duan, Wedong AU - Duan W AD - Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. FAU - Meng, Limin AU - Meng L AD - Department of Medical Imaging, Air Force Medical Center of PLA, Beijing, People's Republic of China. FAU - Huyan, Xiaoyuan AU - Huyan X AD - The First Health Care Department, The Second Medical Center & National Clinical Research Center for Geriatric disease, Chinese PLA general Hospital, Beijing, 100853, People's Republic of China. LA - eng PT - Journal Article DEP - 20220628 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 RN - 0 (Emulsions) RN - 11056-06-7 (Bleomycin) RN - 8008-53-5 (Ethiodized Oil) RN - 9002-89-5 (Polyvinyl Alcohol) SB - IM MH - Adult MH - Bleomycin MH - *Embolization, Therapeutic/methods MH - Emulsions MH - Ethiodized Oil MH - *Focal Nodular Hyperplasia/pathology MH - Humans MH - *Liver Neoplasms/therapy MH - Polyvinyl Alcohol MH - Propensity Score MH - Retrospective Studies MH - Treatment Outcome OTO - NOTNLM OT - Angiography OT - Focal nodular hyperplasia OT - Liver neoplasms OT - Radiology OT - Therapeutic EDAT- 2022/06/29 06:00 MHDA- 2022/09/17 06:00 CRDT- 2022/06/28 11:15 PHST- 2022/03/15 00:00 [received] PHST- 2022/06/14 00:00 [accepted] PHST- 2022/06/06 00:00 [revised] PHST- 2022/06/29 06:00 [pubmed] PHST- 2022/09/17 06:00 [medline] PHST- 2022/06/28 11:15 [entrez] AID - 10.1007/s00330-022-08972-4 [pii] AID - 10.1007/s00330-022-08972-4 [doi] PST - ppublish SO - Eur Radiol. 2022 Oct;32(10):6840-6849. doi: 10.1007/s00330-022-08972-4. Epub 2022 Jun 28.