PMID- 35763663
OWN - NLM
STAT- MEDLINE
DCOM- 20230222
LR  - 20230222
IS  - 1502-3850 (Electronic)
IS  - 0001-6357 (Linking)
VI  - 81
IP  - 2
DP  - 2023 Mar
TI  - Risk of bleeding with dental implant surgery in patients on anticoagulant or 
      antiplatelet drugs: a systematic review and meta-analysis.
PG  - 98-104
LID - 10.1080/00016357.2022.2085324 [doi]
AB  - INTRODUCTION: A large number of patients under oral anticoagulant (OAC) or 
      antiplatelet (AP) therapy require dental implantation. We systematically reviewed 
      evidence on the risk of bleeding after implant placement with continued OAC or AP 
      therapy. METHODS: PubMed, Embase and CENTRAL were searched for studies comparing 
      bleeding outcomes after implant placement between OAC/AP therapy vs. controls or 
      OAC vs. AP therapy. RESULTS: Seven studies were included. Pooled analysis showed 
      no significant difference in the risk of bleeding with continued OAC therapy vs. 
      control (RR 1.81 95% confidence interval [CI] 0.70, 4.63 I(2) = 14% p = .22). 
      Subgroup analysis depending on the type of OAC showed there was a non-significant 
      tendency of increased risk of bleeding with Vitamin K antagonists (VKAs) (RR 3.42 
      95% CI 1.00, 11.67 I(2) = 23% p = .05) but not with direct oral anticoagulants 
      (DOACs) (RR 1.67 95% CI 0.49, 5.70 I(2) = 0% p = .41). Limited data suggest an 
      increased risk of bleeding with OAC as compared to AP (RR 0.08 95% CI 0.01, 0.76 
      I(2) = 0% p = .03). CONCLUSIONS: Continuation of OAC therapy in patients 
      undergoing implant surgery does not increase the risk of bleeding provided local 
      haemostatic measures are used. The indirect comparison suggests bleeding tendency 
      may be higher with VKAs as compared to DOAC.
FAU - Zou, Lilin
AU  - Zou L
AD  - Department of Stomatology, Changshu Hospital Affiliated to Nanjing University of 
      Chinese Medicine, Suzhou, PR China.
FAU - Hua, Li
AU  - Hua L
AD  - Department of Stomatology, The First Affiliated Hospital of Soochow University, 
      Suzhou, PR China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220628
PL  - Sweden
TA  - Acta Odontol Scand
JT  - Acta odontologica Scandinavica
JID - 0370344
RN  - 0 (Anticoagulants)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Dental Implants)
SB  - IM
MH  - Humans
MH  - *Anticoagulants/adverse effects
MH  - Platelet Aggregation Inhibitors/adverse effects
MH  - *Dental Implants/adverse effects
MH  - Hemorrhage/chemically induced/drug therapy
MH  - Administration, Oral
OTO - NOTNLM
OT  - Haemorrhage
OT  - aspirin
OT  - dental Implants
OT  - direct oral anticoagulants
OT  - warfarin
EDAT- 2022/06/29 06:00
MHDA- 2023/02/22 06:00
CRDT- 2022/06/28 15:12
PHST- 2022/06/29 06:00 [pubmed]
PHST- 2023/02/22 06:00 [medline]
PHST- 2022/06/28 15:12 [entrez]
AID - 10.1080/00016357.2022.2085324 [doi]
PST - ppublish
SO  - Acta Odontol Scand. 2023 Mar;81(2):98-104. doi: 10.1080/00016357.2022.2085324. 
      Epub 2022 Jun 28.