PMID- 35764015
OWN - NLM
STAT- MEDLINE
DCOM- 20220817
LR  - 20220817
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 110
DP  - 2022 Sep
TI  - Predictive role of sampling-time specific prognostic nutritional index cut-off 
      values for intravenous immunoglobulin resistance and cardiovascular complications 
      in Kawasaki disease.
PG  - 108986
LID - S1567-5769(22)00470-2 [pii]
LID - 10.1016/j.intimp.2022.108986 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG) resistance and cardiovascular 
      complications prediction are pivotal topic of interests in Kawasaki disease (KD). 
      The prognostic nutritional index (PNI) has been proposed to be valuable in 
      predicting the severity of inflammatory status and prognosis in clinical 
      circumstances, with limited data in KD. Therefore, we prospectively investigated 
      the role of sampling-time specific PNI cut-off values in predicting initial IVIG 
      resistance as well as cardiovascular complications in patients with KD for the 
      first time. METHODS: A total of 755 patients with KD were prospectively recruited 
      between January 2015 and December 2019. Patients with KD were subgrouped based on 
      the presence of IVIG resistance or cardiovascular complications. The clinical and 
      laboratory parameters were compared. Multivariate logistic regression analysis 
      was performed to identify the independent risk factors for IVIG resistance and 
      cardiovascular complications. The receiver operating characteristic (ROC) curve 
      was further applied to assess the predictive values of PNI in IVIG resistance and 
      cardiovascular complications. RESULTS: The lower level of PNI was identified as 
      independent risk factors for initial IVIG resistance and cardiovascular 
      complications. The discriminating cut-off values of the PNI for IVIG resistance, 
      all cardiovascular complications, CALs, KDSS and myocarditis were 47.8, 52.2, 
      38.6, 48.2 and 52.0, with the corresponding sensitivities of 0.573, 0.679, 0.174, 
      0.750, 0.851, and specificities of 0.753, 0.549, 0.957, 0.679 and 0.576, 
      respectively. After sampling time stratification, the sensitivities and 
      specificities of the PNI obtained at the sixth day from fever onset for 
      prediction of both IVIG resistance (0.778, 0.787) and all cardiovascular 
      complications (0.667, 0.753) remarkably improved. CONCLUSION: PNI may serve as a 
      promising predictor for KDSS in patients with KD. PNI obtained at sixth day from 
      fever onset possess good predictive power for both IVIG resistance and all 
      cardiovascular complications in KD.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Liu, Xiaoliang
AU  - Liu X
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Shao, Shuran
AU  - Shao S
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Zhang, Nanjun
AU  - Zhang N
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Wu, Mei
AU  - Wu M
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Liu, Lei
AU  - Liu L
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Duan, Hongyu
AU  - Duan H
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Liu, Zhongqiang
AU  - Liu Z
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Zhou, Kaiyu
AU  - Zhou K
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Hua, Yimin
AU  - Hua Y
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China.
FAU - Wang, Chuan
AU  - Wang C
AD  - Department of Pediatric Cardiology, The Cardiac Development and Early 
      Intervention Unit, The Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children, West China Second University Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China; The Key Laboratory of Development and Diseases of 
      Women and Children of Sichuan Province, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, China; West China Medical School of 
      Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: 
      805101396@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20220625
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Fever/drug therapy
MH  - *Heart Diseases/drug therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Infant
MH  - *Mucocutaneous Lymph Node Syndrome/complications/diagnosis/drug therapy
MH  - Nutrition Assessment
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Cardiovascular complications
OT  - Intravenous immunoglobulin resistance
OT  - Kawasaki disease
OT  - Prognostic nutritional index
EDAT- 2022/06/29 06:00
MHDA- 2022/08/18 06:00
CRDT- 2022/06/28 18:25
PHST- 2022/03/30 00:00 [received]
PHST- 2022/06/05 00:00 [revised]
PHST- 2022/06/17 00:00 [accepted]
PHST- 2022/06/29 06:00 [pubmed]
PHST- 2022/08/18 06:00 [medline]
PHST- 2022/06/28 18:25 [entrez]
AID - S1567-5769(22)00470-2 [pii]
AID - 10.1016/j.intimp.2022.108986 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2022 Sep;110:108986. doi: 10.1016/j.intimp.2022.108986. Epub 
      2022 Jun 25.