PMID- 35765097
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1738-6055 (Print)
IS  - 2233-7660 (Electronic)
IS  - 1738-6055 (Linking)
VI  - 38
IP  - 1
DP  - 2022 Jun 28
TI  - Laboratory information management system for COVID-19 non-clinical efficacy trial 
      data.
PG  - 17
LID - 10.1186/s42826-022-00127-2 [doi]
LID - 17
AB  - BACKGROUND: As the number of large-scale studies involving multiple organizations 
      producing data has steadily increased, an integrated system for a common 
      interoperable format is needed. In response to the coronavirus disease 2019 
      (COVID-19) pandemic, a number of global efforts are underway to develop vaccines 
      and therapeutics. We are therefore observing an explosion in the proliferation of 
      COVID-19 data, and interoperability is highly requested in multiple institutions 
      participating simultaneously in COVID-19 pandemic research. RESULTS: In this 
      study, a laboratory information management system (LIMS) approach has been 
      adopted to systemically manage various COVID-19 non-clinical trial data, 
      including mortality, clinical signs, body weight, body temperature, organ 
      weights, viral titer (viral replication and viral RNA), and multiorgan 
      histopathology, from multiple institutions based on a web interface. The main aim 
      of the implemented system is to integrate, standardize, and organize data 
      collected from laboratories in multiple institutes for COVID-19 non-clinical 
      efficacy testings. Six animal biosafety level 3 institutions proved the 
      feasibility of our system. Substantial benefits were shown by maximizing 
      collaborative high-quality non-clinical research. CONCLUSIONS: This LIMS platform 
      can be used for future outbreaks, leading to accelerated medical product 
      development through the systematic management of extensive data from non-clinical 
      animal studies.
CI  - (c) 2022. The Author(s).
FAU - Yoon, Suhyeon
AU  - Yoon S
AD  - Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic 
      of Korea.
FAU - Noh, Hyuna
AU  - Noh H
AD  - Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic 
      of Korea.
FAU - Jin, Heejin
AU  - Jin H
AD  - Institute of Health and Environment, Seoul National University, Seoul, 08826, 
      Republic of Korea.
FAU - Lee, Sungyoung
AU  - Lee S
AD  - Department of Genomic Medicine, Seoul National University Hospital, Seoul, 03080, 
      Republic of Korea.
AD  - Department of Medicine, Seoul National University College of Medicine, Seoul, 
      03080, Republic of Korea.
FAU - Han, Soyul
AU  - Han S
AD  - RexSoft Corp, Seoul, 08826, Republic of Korea.
FAU - Kim, Sung-Hee
AU  - Kim SH
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Kim, Jiseon
AU  - Kim J
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Seo, Jung Seon
AU  - Seo JS
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Kim, Jeong Jin
AU  - Kim JJ
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Park, In Ho
AU  - Park IH
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
AD  - Institute of Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, 03722, Republic of Korea.
FAU - Oh, Jooyeon
AU  - Oh J
AD  - Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, 
      Republic of Korea.
FAU - Bae, Joon-Yong
AU  - Bae JY
AD  - Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea 
      University College of Medicine, Seoul, 02841, Republic of Korea.
FAU - Lee, Gee Eun
AU  - Lee GE
AD  - Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea 
      University College of Medicine, Seoul, 02841, Republic of Korea.
FAU - Woo, Sun-Je
AU  - Woo SJ
AD  - Science Unit, International Vaccine Institute, Seoul, 08826, Republic of Korea.
FAU - Seo, Sun-Min
AU  - Seo SM
AD  - Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk 
      University, Seoul, 05029, Republic of Korea.
FAU - Kim, Na-Won
AU  - Kim NW
AD  - Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk 
      University, Seoul, 05029, Republic of Korea.
FAU - Lee, Youn Woo
AU  - Lee YW
AD  - Department of Nuclear Medicine, Seoul National University Bundang Hospital, 
      Seongnam, 13488, Republic of Korea.
FAU - Jang, Hui Jeong
AU  - Jang HJ
AD  - Department of Nuclear Medicine, Seoul National University Bundang Hospital, 
      Seongnam, 13488, Republic of Korea.
FAU - Hong, Seung-Min
AU  - Hong SM
AD  - Laboratory of Avian Diseases, BK21 Plus Program for Veterinary Science and 
      Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul 
      National University, Seoul, 08826, Republic of Korea.
FAU - An, Se-Hee
AU  - An SH
AD  - Laboratory of Avian Diseases, BK21 Plus Program for Veterinary Science and 
      Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul 
      National University, Seoul, 08826, Republic of Korea.
FAU - Lyoo, Kwang-Soo
AU  - Lyoo KS
AD  - Korea Zoonosis Research Institute, Chonbuk National University, Iksan, 54531, 
      Republic of Korea.
FAU - Yeom, Minjoo
AU  - Yeom M
AD  - Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, 
      Republic of Korea.
FAU - Lee, Hanbyeul
AU  - Lee H
AD  - Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, 
      Republic of Korea.
FAU - Jung, Bud
AU  - Jung B
AD  - Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, 
      Republic of Korea.
FAU - Yoon, Sun-Woo
AU  - Yoon SW
AD  - Bionanotechnology Research Center, Korea Research Institute of Bioscience and 
      Biotechnology, Daejeon, 34141, Republic of Korea.
FAU - Kang, Jung-Ah
AU  - Kang JA
AD  - Bionanotechnology Research Center, Korea Research Institute of Bioscience and 
      Biotechnology, Daejeon, 34141, Republic of Korea.
FAU - Seok, Sang-Hyuk
AU  - Seok SH
AD  - Division of Biomedical Convergence, College of Biomedical Science, Kangwon 
      National University, ChunCheon, 24341, Republic of Korea.
FAU - Lee, Yu Jin
AU  - Lee YJ
AD  - Division of Biomedical Convergence, College of Biomedical Science, Kangwon 
      National University, ChunCheon, 24341, Republic of Korea.
FAU - Kim, Seo Yeon
AU  - Kim SY
AD  - Preclinical Research Center, Seoul National University Bundang Hospital, 
      Seongnam, 13488, Republic of Korea.
FAU - Kim, Young Been
AU  - Kim YB
AD  - Preclinical Research Center, Seoul National University Bundang Hospital, 
      Seongnam, 13488, Republic of Korea.
FAU - Hwang, Ji-Yeon
AU  - Hwang JY
AD  - Preclinical Research Center, Seoul National University Bundang Hospital, 
      Seongnam, 13488, Republic of Korea.
FAU - On, Dain
AU  - On D
AD  - Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic 
      of Korea.
AD  - Laboratory of Developmental Biology and Genomics, Research Institute for 
      Veterinary Science, BK21 PLUS Program for Creative Veterinary Science Research, 
      College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic 
      of Korea.
FAU - Lim, Soo-Yeon
AU  - Lim SY
AD  - Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic 
      of Korea.
FAU - Kim, Sol Pin
AU  - Kim SP
AD  - Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic 
      of Korea.
FAU - Jang, Ji Yun
AU  - Jang JY
AD  - Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 
      Gyeonggi, 10408, Republic of Korea.
AD  - College of Pharmacy, Dongguk University, Seoul, 04620, Republic of Korea.
FAU - Lee, Ho
AU  - Lee H
AD  - Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, 
      Gyeonggi, 10408, Republic of Korea.
FAU - Kim, Kyoungmi
AU  - Kim K
AD  - Department of Biomedical Sciences and Department of Physiology, Korea University 
      College of Medicine, Seoul, 02841, Republic of Korea.
FAU - Lee, Hyo-Jung
AU  - Lee HJ
AD  - Department of Periodontology, Section of Dentistry, Seoul National University 
      Bundang Hospital, Seongnam, 13620, Republic of Korea.
FAU - Kim, Hong Bin
AU  - Kim HB
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Seoul National University College of Medicine, Seongnam, 13620, Republic of 
      Korea.
FAU - Park, Jun Won
AU  - Park JW
AD  - Division of Biomedical Convergence, College of Biomedical Science, Kangwon 
      National University, ChunCheon, 24341, Republic of Korea.
FAU - Jeong, Dae Gwin
AU  - Jeong DG
AD  - Bionanotechnology Research Center, Korea Research Institute of Bioscience and 
      Biotechnology, Daejeon, 34141, Republic of Korea.
FAU - Song, Daesub
AU  - Song D
AD  - Department of Pharmacy, College of Pharmacy, Korea University, Sejong, 30019, 
      Republic of Korea.
FAU - Choi, Kang-Seuk
AU  - Choi KS
AD  - Laboratory of Avian Diseases, BK21 Plus Program for Veterinary Science and 
      Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul 
      National University, Seoul, 08826, Republic of Korea.
FAU - Lee, Ho-Young
AU  - Lee HY
AD  - Department of Nuclear Medicine, Seoul National University Bundang Hospital, 
      Seongnam, 13488, Republic of Korea.
FAU - Choi, Yang-Kyu
AU  - Choi YK
AD  - Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk 
      University, Seoul, 05029, Republic of Korea.
FAU - Choi, Jung-Ah
AU  - Choi JA
AD  - Science Unit, International Vaccine Institute, Seoul, 08826, Republic of Korea.
FAU - Song, Manki
AU  - Song M
AD  - Science Unit, International Vaccine Institute, Seoul, 08826, Republic of Korea.
FAU - Park, Man-Seong
AU  - Park MS
AD  - Department of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea 
      University College of Medicine, Seoul, 02841, Republic of Korea.
FAU - Seo, Jun-Young
AU  - Seo JY
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Nam, Ki Taek
AU  - Nam KT
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Shin, Jeon-Soo
AU  - Shin JS
AD  - Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical 
      Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
AD  - Institute of Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, 03722, Republic of Korea.
AD  - Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, 
      Republic of Korea.
FAU - Won, Sungho
AU  - Won S
AD  - Institute of Health and Environment, Seoul National University, Seoul, 08826, 
      Republic of Korea. Won1@snu.ac.kr.
AD  - RexSoft Corp, Seoul, 08826, Republic of Korea. Won1@snu.ac.kr.
AD  - Department of Public Health Sciences, Seoul National University, Seoul, 08826, 
      Republic of Korea. Won1@snu.ac.kr.
FAU - Yun, Jun-Won
AU  - Yun JW
AD  - Laboratory of Veterinary Toxicology, College of Veterinary Medicine, Seoul 
      National University, Seoul, 08826, Republic of Korea. jwyun@snu.ac.kr.
FAU - Seong, Je Kyung
AU  - Seong JK
AD  - Korea Mouse Phenotyping Center, Seoul National University, Seoul, 08826, Republic 
      of Korea. snumouse@snu.ac.kr.
AD  - Laboratory of Developmental Biology and Genomics, Research Institute for 
      Veterinary Science, BK21 PLUS Program for Creative Veterinary Science Research, 
      College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic 
      of Korea. snumouse@snu.ac.kr.
AD  - Interdisciplinary Program for Bioinformatics, Program for Cancer Biology, 
      BIO-MAX/N-Bio Institute, Seoul National University, Seoul, 08826, Republic of 
      Korea. snumouse@snu.ac.kr.
LA  - eng
GR  - 2020M3A9I2109027/National research foundation of Korea/
GR  - 2021M3H9A1030260/National research foundation of Korea/
PT  - Journal Article
DEP - 20220628
PL  - England
TA  - Lab Anim Res
JT  - Laboratory animal research
JID - 101560684
PMC - PMC9238008
OTO - NOTNLM
OT  - COVID-19
OT  - Data
OT  - Laboratory information management system
OT  - Non-clinical
OT  - SARS-CoV-2
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/06/29 06:00
MHDA- 2022/06/29 06:01
PMCR- 2022/06/28
CRDT- 2022/06/28 23:45
PHST- 2022/02/14 00:00 [received]
PHST- 2022/06/09 00:00 [accepted]
PHST- 2022/06/28 23:45 [entrez]
PHST- 2022/06/29 06:00 [pubmed]
PHST- 2022/06/29 06:01 [medline]
PHST- 2022/06/28 00:00 [pmc-release]
AID - 10.1186/s42826-022-00127-2 [pii]
AID - 127 [pii]
AID - 10.1186/s42826-022-00127-2 [doi]
PST - epublish
SO  - Lab Anim Res. 2022 Jun 28;38(1):17. doi: 10.1186/s42826-022-00127-2.