PMID- 35765844
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20240102
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 152
IP  - 2
DP  - 2023 Jan 15
TI  - Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic 
      ductal adenocarcinoma.
PG  - 110-122
LID - 10.1002/ijc.34195 [doi]
AB  - Pancreatic cancer (PC) is a cancer of the digestive system, and pancreatic ductal 
      adenocarcinoma (PDAC) accounts for approximately 90% of all PC cases. Exosomes 
      derived from PDAC (PDAC-exosomes) promote PDAC development and metastasis. 
      Exosomes are nanoscale vesicles secreted by most cells, which can carry 
      biologically active molecules and mediate communication and cargo transportation 
      among cells. Recent studies have focused on transforming exosomes into good drug 
      delivery systems (DDSs) to improve the clinical treatment of PDAC. This review 
      considers PDAC as the main research object to introduce the role of PDAC-exosomes 
      in PDAC development and metastasis. This review focuses on the following two 
      themes: (a) the great potential of PDAC-exosomes as new diagnostic markers for 
      PDAC, and (b) the transformation of exosomes into potential DDSs.
CI  - (c) 2022 The Authors. International Journal of Cancer published by John Wiley & 
      Sons Ltd on behalf of UICC.
FAU - Xu, Biaoming
AU  - Xu B
AD  - Department of Gastroduodenal and Pancreatic Surgery, Translational Medicine Joint 
      Research Center of Liver Cancer of Hunan University, Laboratory of Digestive 
      Oncology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer 
      Hospital, Central South University, Changsha, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Institute of Pathogen Biology and Immunology of College of Biology, Hunan 
      Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.
FAU - Peng, Mingjing
AU  - Peng M
AD  - Department of Gastroduodenal and Pancreatic Surgery, Translational Medicine Joint 
      Research Center of Liver Cancer of Hunan University, Laboratory of Digestive 
      Oncology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer 
      Hospital, Central South University, Changsha, China.
FAU - Zheng, Jin Hai
AU  - Zheng JH
AD  - Institute of Pathogen Biology and Immunology of College of Biology, Hunan 
      Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.
FAU - Zuo, Chaohui
AU  - Zuo C
AUID- ORCID: 0000-0002-1774-9259
AD  - Department of Gastroduodenal and Pancreatic Surgery, Translational Medicine Joint 
      Research Center of Liver Cancer of Hunan University, Laboratory of Digestive 
      Oncology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer 
      Hospital, Central South University, Changsha, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220713
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Humans
MH  - *Exosomes/pathology
MH  - Cell Line, Tumor
MH  - *Carcinoma, Pancreatic Ductal/diagnosis/drug therapy/pathology
MH  - *Pancreatic Neoplasms/diagnosis/drug therapy/pathology
MH  - Drug Delivery Systems
PMC - PMC9796664
OTO - NOTNLM
OT  - diagnosis and treatment
OT  - drug delivery systems
OT  - exosomes
OT  - pancreatic ductal adenocarcinoma
OT  - tumor microenvironment
COIS- All the authors of this article have no conflicts of interest.
EDAT- 2022/06/30 06:00
MHDA- 2022/11/23 06:00
PMCR- 2022/12/28
CRDT- 2022/06/29 03:22
PHST- 2022/05/30 00:00 [revised]
PHST- 2021/08/15 00:00 [received]
PHST- 2022/06/09 00:00 [accepted]
PHST- 2022/06/30 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/06/29 03:22 [entrez]
PHST- 2022/12/28 00:00 [pmc-release]
AID - IJC34195 [pii]
AID - 10.1002/ijc.34195 [doi]
PST - ppublish
SO  - Int J Cancer. 2023 Jan 15;152(2):110-122. doi: 10.1002/ijc.34195. Epub 2022 Jul 
      13.